FA83E_MOUSE
ID FA83E_MOUSE Reviewed; 481 AA.
AC Q80XS7; B9EIA0; Q3UN25;
DT 15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT 15-JAN-2008, sequence version 2.
DT 03-AUG-2022, entry version 101.
DE RecName: Full=Protein FAM83E {ECO:0000305};
GN Name=Fam83e {ECO:0000312|MGI:MGI:1921063};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=FVB/N; TISSUE=Brain, and Colon;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-255.
RC STRAIN=C57BL/6J; TISSUE=Gall bladder;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
CC -!- FUNCTION: May play a role in MAPK signaling.
CC {ECO:0000250|UniProtKB:Q2M2I3}.
CC -!- SUBUNIT: May interact with RAF1. {ECO:0000250|UniProtKB:Q2M2I3}.
CC -!- SIMILARITY: Belongs to the FAM83 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAI39285.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact.; Evidence={ECO:0000305};
CC Sequence=BAE25923.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact.; Evidence={ECO:0000305};
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DR EMBL; AC167242; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC042793; AAH42793.1; -; mRNA.
DR EMBL; BC139284; AAI39285.1; ALT_SEQ; mRNA.
DR EMBL; AK144522; BAE25923.1; ALT_SEQ; mRNA.
DR CCDS; CCDS39959.2; -.
DR RefSeq; NP_001028342.2; NM_001033170.4.
DR AlphaFoldDB; Q80XS7; -.
DR SMR; Q80XS7; -.
DR STRING; 10090.ENSMUSP00000114397; -.
DR PhosphoSitePlus; Q80XS7; -.
DR PaxDb; Q80XS7; -.
DR PRIDE; Q80XS7; -.
DR ProteomicsDB; 275842; -.
DR Antibodypedia; 45772; 31 antibodies from 11 providers.
DR Ensembl; ENSMUST00000129507; ENSMUSP00000114397; ENSMUSG00000054161.
DR GeneID; 73813; -.
DR KEGG; mmu:73813; -.
DR UCSC; uc009gwx.1; mouse.
DR CTD; 54854; -.
DR MGI; MGI:1921063; Fam83e.
DR VEuPathDB; HostDB:ENSMUSG00000054161; -.
DR eggNOG; ENOG502QWTG; Eukaryota.
DR GeneTree; ENSGT00940000161572; -.
DR HOGENOM; CLU_019056_4_0_1; -.
DR InParanoid; Q80XS7; -.
DR OMA; VVRGCTF; -.
DR OrthoDB; 606817at2759; -.
DR PhylomeDB; Q80XS7; -.
DR TreeFam; TF330777; -.
DR BioGRID-ORCS; 73813; 1 hit in 72 CRISPR screens.
DR PRO; PR:Q80XS7; -.
DR Proteomes; UP000000589; Chromosome 7.
DR RNAct; Q80XS7; protein.
DR Bgee; ENSMUSG00000054161; Expressed in left colon and 44 other tissues.
DR Genevisible; Q80XS7; MM.
DR GO; GO:0019901; F:protein kinase binding; ISO:MGI.
DR GO; GO:0007165; P:signal transduction; IBA:GO_Central.
DR InterPro; IPR012461; FAM83_N.
DR Pfam; PF07894; FAM83; 1.
PE 2: Evidence at transcript level;
KW Reference proteome.
FT CHAIN 1..481
FT /note="Protein FAM83E"
FT /id="PRO_0000314930"
FT REGION 351..481
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 353..404
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 461..481
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 481 AA; 52578 MW; 458BBE85F6B3AA9A CRC64;
MAASQLAALE GEELGAGEPA LTKASPAVLY SEGQRLALEA LLSSGEETFW ACVQQERLPP
FLSADEAQAL ATAAEDWLVP SQEPGAAGTG TAITDGDVGS LTYWPRQSEE PAPLLRLGWP
EDTAWKGITR AQLYTQPPGE GQPPIKELVH QEIQAARKLV AVVMDVFTDP DLLRDMVDAA
TRRWIPVYLL LDHQHLPAFL ALAQQLGVNL WTTENLDIRT VQGHTFQSRR RRQVSGHVRE
KFVLLDGDRV ISGSYSFTWS DSRLHRSLVT LLTGEIADAF NQEFRVLYAA SRPLSAAPAR
SPLFSPPEGP QLPRSPHRVA LRCPVAPVAP LLSDGPLAQR LAACHILERD KQETPTTTGP
ALSDILRSVQ RTRTTSGPPT RPSRSLWDLS RLSQLSGSSD GENESKKFWV SKDTPARALM
RQRGTGGGPR AEMDSRSQPW GGPLPSIPAR RLRYLSPAQR RLGDNATTSD WASGSGSGRR
R
