FA83F_MOUSE
ID FA83F_MOUSE Reviewed; 495 AA.
AC Q3UKU4; Q8C578; Q8CDC4; Q8R3Z0;
DT 15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT 11-OCT-2005, sequence version 1.
DT 25-MAY-2022, entry version 98.
DE RecName: Full=Protein FAM83F;
GN Name=Fam83f;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Cerebellum, Intestine, and Placenta;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=129; TISSUE=Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-477, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Pancreas;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- SIMILARITY: Belongs to the FAM83 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAC37615.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact.; Evidence={ECO:0000305};
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DR EMBL; AK030342; BAC26912.1; -; mRNA.
DR EMBL; AK079344; BAC37615.1; ALT_SEQ; mRNA.
DR EMBL; AK145865; BAE26707.1; -; mRNA.
DR EMBL; BC016600; AAH16600.2; -; mRNA.
DR CCDS; CCDS49672.1; -.
DR RefSeq; NP_666098.2; NM_145986.2.
DR AlphaFoldDB; Q3UKU4; -.
DR SMR; Q3UKU4; -.
DR STRING; 10090.ENSMUSP00000023044; -.
DR iPTMnet; Q3UKU4; -.
DR PhosphoSitePlus; Q3UKU4; -.
DR MaxQB; Q3UKU4; -.
DR PaxDb; Q3UKU4; -.
DR PRIDE; Q3UKU4; -.
DR ProteomicsDB; 266832; -.
DR DNASU; 213956; -.
DR GeneID; 213956; -.
DR KEGG; mmu:213956; -.
DR UCSC; uc007wvr.1; mouse.
DR CTD; 113828; -.
DR MGI; MGI:2146227; Fam83f.
DR eggNOG; ENOG502QPW1; Eukaryota.
DR InParanoid; Q3UKU4; -.
DR OrthoDB; 354494at2759; -.
DR PhylomeDB; Q3UKU4; -.
DR TreeFam; TF330777; -.
DR BioGRID-ORCS; 213956; 2 hits in 74 CRISPR screens.
DR PRO; PR:Q3UKU4; -.
DR Proteomes; UP000000589; Unplaced.
DR RNAct; Q3UKU4; protein.
DR GO; GO:0019901; F:protein kinase binding; IBA:GO_Central.
DR GO; GO:0007165; P:signal transduction; IBA:GO_Central.
DR InterPro; IPR012461; FAM83_N.
DR Pfam; PF07894; FAM83; 1.
PE 1: Evidence at protein level;
KW Acetylation; Phosphoprotein; Reference proteome.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000250|UniProtKB:Q8NEG4"
FT CHAIN 2..495
FT /note="Protein FAM83F"
FT /id="PRO_0000314951"
FT REGION 341..362
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 384..495
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 400..414
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 475..495
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 2
FT /note="N-acetylalanine"
FT /evidence="ECO:0000250|UniProtKB:Q8NEG4"
FT MOD_RES 4
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8NEG4"
FT MOD_RES 477
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT CONFLICT 91
FT /note="F -> V (in Ref. 1; BAC26912/BAC37615 and 2;
FT AAH16600)"
FT /evidence="ECO:0000305"
FT CONFLICT 303
FT /note="R -> G (in Ref. 1; BAC26912)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 495 AA; 55012 MW; 4253AD10BE93B658 CRC64;
MAESQLSCLD EAHVNERVTE AHAAFYYCER RRAALEALLG GGEQAYRELV KKERLRDFLS
SQERQALCAA WSPYEEAVSS TRAKAKAKAK FPAQPTESLA YWPDRSDTEV PPLDLGWTDT
NFYRGVSRVT LFTHPPKEEK APHLKQVVRQ MIQQAQKVIA VVMDLFTDGD IFQDIVDAAC
KRRVPVYIIL DEGGVKYFLE MCQGLELADF RIRNIRVRSV TGIGFYMPMG KIKGTLSSKF
LMVDGDKVAT GSFSFTWSSS YVDRNLLLLL TGQNMEPFDI EFRELYAISE EVNLHQHLGL
AGRIGLNYSS TVARKLINPK YALVAGTRRP PGEMMRWAAR QQREAGGNVE GQEEGSGGGE
SARRLESFLN DLVTVEQILP TVEPISPRLQ RPTNGRPVSH AHTDAKHRSR EALPQNGKGE
AANGEATPAK EGKRFSSRLF SRRVKRPAVP SSMASSPSTE TFADVEFPLG KRHNEGSNAN
ISGKGITKAS NCVIS
