FA83G_MOUSE
ID FA83G_MOUSE Reviewed; 812 AA.
AC Q5SWY7; Q5U437; Q8C1B0;
DT 29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 21-DEC-2004, sequence version 1.
DT 03-AUG-2022, entry version 101.
DE RecName: Full=Protein FAM83G;
GN Name=Fam83g;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Skin;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Embryo;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Kidney, and Pancreas;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: May regulate the bone morphogenetic proteins (BMP) pathway.
CC {ECO:0000250|UniProtKB:A6ND36}.
CC -!- SUBUNIT: Found in a macromolecular complex with SMAD1. Interacts with
CC SMAD1 (via MH2 domain); in a SMAD4-independent manner.
CC {ECO:0000250|UniProtKB:A6ND36}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol
CC {ECO:0000250|UniProtKB:A6ND36}. Nucleus {ECO:0000250|UniProtKB:A6ND36}.
CC Note=Detected predominantly in cytosolic. Upon BMP stimulation, a small
CC portion of PAWS1 is detected in the nucleus.
CC {ECO:0000250|UniProtKB:A6ND36}.
CC -!- PTM: BMP signaling induces the phosphorylation of PAWS1 through BMPR1A
CC at Ser-609, Ser-613 and Ser-615. In response to BMP phosphorylation at
CC Ser-609 is necessary for the activation of SMAD4-independent BMP target
CC genes such as NEDD9 and ASNS. {ECO:0000250|UniProtKB:A6ND36}.
CC -!- SIMILARITY: Belongs to the FAM83 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAC26012.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; AK028566; BAC26012.1; ALT_FRAME; mRNA.
DR EMBL; AL596209; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC085279; AAH85279.1; -; mRNA.
DR CCDS; CCDS36175.1; -.
DR RefSeq; NP_848733.2; NM_178618.3.
DR RefSeq; XP_006534182.1; XM_006534119.3.
DR AlphaFoldDB; Q5SWY7; -.
DR SMR; Q5SWY7; -.
DR STRING; 10090.ENSMUSP00000090697; -.
DR iPTMnet; Q5SWY7; -.
DR PhosphoSitePlus; Q5SWY7; -.
DR MaxQB; Q5SWY7; -.
DR PaxDb; Q5SWY7; -.
DR PRIDE; Q5SWY7; -.
DR ProteomicsDB; 266833; -.
DR Antibodypedia; 6816; 102 antibodies from 19 providers.
DR Ensembl; ENSMUST00000093019; ENSMUSP00000090697; ENSMUSG00000042377.
DR GeneID; 69640; -.
DR KEGG; mmu:69640; -.
DR UCSC; uc007jid.1; mouse.
DR CTD; 644815; -.
DR MGI; MGI:1916890; Fam83g.
DR VEuPathDB; HostDB:ENSMUSG00000042377; -.
DR eggNOG; ENOG502QS42; Eukaryota.
DR GeneTree; ENSGT00940000157932; -.
DR HOGENOM; CLU_019056_1_0_1; -.
DR InParanoid; Q5SWY7; -.
DR OMA; HSEQMAN; -.
DR OrthoDB; 354494at2759; -.
DR PhylomeDB; Q5SWY7; -.
DR TreeFam; TF330777; -.
DR BioGRID-ORCS; 69640; 2 hits in 71 CRISPR screens.
DR ChiTaRS; Fam83g; mouse.
DR PRO; PR:Q5SWY7; -.
DR Proteomes; UP000000589; Chromosome 11.
DR RNAct; Q5SWY7; protein.
DR Bgee; ENSMUSG00000042377; Expressed in lip and 76 other tissues.
DR Genevisible; Q5SWY7; MM.
DR GO; GO:0005829; C:cytosol; ISS:UniProtKB.
DR GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR GO; GO:0019901; F:protein kinase binding; IBA:GO_Central.
DR GO; GO:0030509; P:BMP signaling pathway; ISS:UniProtKB.
DR GO; GO:0007165; P:signal transduction; IBA:GO_Central.
DR InterPro; IPR012461; FAM83_N.
DR Pfam; PF07894; FAM83; 1.
PE 1: Evidence at protein level;
KW Acetylation; Cytoplasm; Nucleus; Phosphoprotein; Reference proteome.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000250|UniProtKB:A6ND36"
FT CHAIN 2..812
FT /note="Protein FAM83G"
FT /id="PRO_0000330818"
FT REGION 76..119
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 362..389
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 455..509
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 521..812
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 539..562
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 575..589
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 2
FT /note="N-acetylalanine"
FT /evidence="ECO:0000250|UniProtKB:A6ND36"
FT MOD_RES 4
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:A6ND36"
FT MOD_RES 124
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:A6ND36"
FT MOD_RES 127
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:A6ND36"
FT MOD_RES 356
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:A6ND36"
FT MOD_RES 609
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:A6ND36"
FT MOD_RES 613
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:A6ND36"
FT MOD_RES 615
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:A6ND36"
FT MOD_RES 649
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:A6ND36"
FT CONFLICT 18
FT /note="S -> F (in Ref. 3; AAH85279)"
FT /evidence="ECO:0000305"
FT CONFLICT 747
FT /note="L -> V (in Ref. 1; BAC26012)"
FT /evidence="ECO:0000305"
FT CONFLICT 800
FT /note="S -> L (in Ref. 3; AAH85279)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 812 AA; 89830 MW; D3B9A9EBCD15DD15 CRC64;
MAFSQVQCLD DNHVNWRSSE SKPEFFYSEE QRLALEALVA RGRDAFYEVL KRENIRDFLS
ELELSRIVEA IEVYDPGSED PRVSGRRPEP QDNGGADASE ETSAAGGPPA TETLPSLEYW
PQKSDRSIPQ LDLGWPDTIA YRGVTRASVY MQPPIDGQPH IKEVVRKMVS QAQKVIAVVM
DMFTDVDIFK DLLDAGFKRK VAVYIIVDES NVKYFLHMCE RARMHLGHLK NLRVRSSGGT
EFFTRSATKF KGVLAQKFMF VDGDRAVCGS YSFTWSAART DRNVISVLSG QVVEMFDRQF
QELYLMSQSV SLKDIPMEKE PEPEPIVLPS VVPLVPTGTM AKKLVNPKYA LVKAKSVDEI
AKSSSDKQEV TRPPGLRGPA VAERPGDLSE LLPPVHPGLL NLERANMFEY LPTWVEPDPE
PGSDILGYIN IIDPNIWNPQ PNQMNRIKIR DTAHASAQHQ LWKQSQGARP CPAPCPPPAP
RDSQGVVPAE NGFPQGNPEP QAPVPKPRTV PVASVLARDG SDIGWALDTP EKETPQNGID
PRLPSTASES EVPQQQHSSM TQDDPDGLER GLPNGLDEDE DDDDDYVTLS DQDSLSGSSG
PGPGHRRPSV ASSMSDEYFE VRERSVPLQR RHSEQMANGP GHPPRRQLSA PHVTRGTFGG
PLSSPLWAQG RSREDVDASR IQGQRPMDRQ AQGQHFHRHG STTSRTPGPP RFRPAADGTQ
SSSKKASPAA AGPHHWQPKG SPTPRMLPDP GSPRPTRNTR LRAELRATEE HASPFGIPYS
KLSQSKHLKA RAGGSQWAPS DSKRRARDHK EP
