ID   FA83H_XENTR             Reviewed;        1277 AA.
AC   A9JRM0;
DT   18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT   18-MAR-2008, sequence version 2.
DT   03-AUG-2022, entry version 54.
DE   RecName: Full=Protein FAM83H {ECO:0000305};
GN   Name=fam83h {ECO:0000250|UniProtKB:Q6ZRV2};
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (DEC-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May play a role in keratin cytoskeleton disassembly.
CC       {ECO:0000250|UniProtKB:Q6ZRV2}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC       {ECO:0000250|UniProtKB:Q6ZRV2}. Note=Colocalizes with keratin
CC       filaments. {ECO:0000250|UniProtKB:Q6ZRV2}.
CC   -!- SIMILARITY: Belongs to the FAM83 family. {ECO:0000305}.
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DR   EMBL; BC155711; AAI55712.1; -; mRNA.
DR   RefSeq; XP_002943716.3; XM_002943670.4.
DR   AlphaFoldDB; A9JRM0; -.
DR   SMR; A9JRM0; -.
DR   STRING; 8364.ENSXETP00000011553; -.
DR   PaxDb; A9JRM0; -.
DR   eggNOG; ENOG502QW7K; Eukaryota.
DR   InParanoid; A9JRM0; -.
DR   OrthoDB; 84242at2759; -.
DR   Proteomes; UP000008143; Genome assembly.
DR   Proteomes; UP000790000; Unplaced.
DR   Bgee; ENSXETG00000005283; Expressed in early embryo and 18 other tissues.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR   GO; GO:0045104; P:intermediate filament cytoskeleton organization; ISS:UniProtKB.
DR   CDD; cd09188; PLDc_FAM83H_N; 1.
DR   InterPro; IPR012461; FAM83_N.
DR   InterPro; IPR041996; PLDc_FAM83H_N.
DR   Pfam; PF07894; FAM83; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Cytoskeleton; Reference proteome.
FT   CHAIN           1..1277
FT                   /note="Protein FAM83H"
FT                   /id="PRO_0000324491"
FT   REGION          1..20
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          67..98
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          717..756
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          772..805
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          971..1018
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1070..1130
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1158..1225
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1247..1266
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..15
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        69..98
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        728..747
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1070..1093
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1108..1130
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1158..1214
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1277 AA;  143246 MW;  594863E056C1AE63 CRC64;
     MARRSQSSSQ GENPLDPNYL PPHYKEYYRI AIDALAENGP EAYEQFLMEE GAPDFLCPNE
     VEHISRSLQR PPESGQENPY PDSVYGSQED ADGSSGTYWP MDSDTAAPEL DLGWPTIYGF
     QGTEVTTLMH PPPPDNPTIK EEVRRMIRSA QQVIGIVMDI FTDADILSEL LDAANRRIPV
     YIILDQMNCQ LFLDMAAKYR VNLNYVEFLR VRTVSGPTYF CRKGSTFKGN LQEKFLLVDC
     TMVLSGTYSF MWSFEKIHRS IAHIFQGELV SSFDEEFRIL FAQSDPLIPS ESALAKMDKS
     YMGMVPFAGP RPMFDRKLHF MFPREENPSQ QFPSYGVDPD RHYFQPFRRE DMIRQTMDPG
     GMRMYGKNLG DPMDKMQMSF VQNKQLEAME AFKRHSFAEG TFENYTSSRQ YSRQMFMNNN
     DEYRLQSSQV QKSQFMQFQS PLGTARPQGL FEKIRGGRQG LQEMDEFDSR YPTKGLPGEG
     HFALDGPPMR PGYNPSNSSR EVRHGSDQMV IGGEGRFGQR SLGRQKFMCQ ISPTQKQGME
     PKYFFHDQDA DKKPQENKQG LRSWRISSYL SGIQSDQDEE GLPIPLDPEL YDDALVPVER
     AVPASDTLFK YSMDPVPPYH PGTAPHDLPY DRANENPMKF SMDPVQLHRP NVPSQDVPMH
     LERAGNESLV KYSLDPIPPF KPNVAGTDVP MPLERKPTAN EILSRYSVDP IPPYKTFGST
     GDLSVEKAKE NPPAEKEKEE GLLSRHDSFR TRTNPLIQRG SRLRSSLIFS SSKLEQHTST
     AESVQEMQKE QSTSELVSEN ETGRTTSKVA EILQKYRGIN KDANSTTVTQ AKAASRTIHE
     ESEDGQSVSA EEVAYKAVES TVDTKGSMSH VQQESQYRSV ASSHLESLLG KHQTTLSMSK
     VEQMTSSIQT IGNISAAPSE SGPTVPELSE VHKQSSISHM QQESHYKSVV TSKLEGLLNR
     DQQVMSMSKV EQTSSTIQTI GNISPAPPDS KESGPTITEV TEATQSSENL PTRPNSAFHF
     GSALESMSQN PTPSSSLNKS EEDLAKTDQN FFRKGSMRLK QFLQSKAEKK AEEDLASDNA
     KAEKQHSTLR RLSKSDSQEV AASTDMEEKS AKSLSVSPPK TSSISQSRLS ASTSNVIFSS
     NLRDDTKVIL EQISANSQKN RAEMVKQAQQ IQATGDPDPA TSKPESKTEG TASTDAAAIT
     RTGSFLSRSR FSRPSPSSPE DRDILLKRME SIRKEKRVYS RFEVFCKKDE QPSHADDNDD
     KKAGKIIPKL LGNLIKK