FA89A_HUMAN
ID FA89A_HUMAN Reviewed; 184 AA.
AC Q96GI7;
DT 09-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 03-AUG-2022, entry version 127.
DE RecName: Full=Protein FAM89A;
GN Name=FAM89A; Synonyms=C1orf153;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16710414; DOI=10.1038/nature04727;
RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT "The DNA sequence and biological annotation of human chromosome 1.";
RL Nature 441:315-321(2006).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Muscle;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Erythroleukemia;
RX PubMed=23186163; DOI=10.1021/pr300630k;
RA Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA Mohammed S.;
RT "Toward a comprehensive characterization of a human cancer cell
RT phosphoproteome.";
RL J. Proteome Res. 12:260-271(2013).
RN [4]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Liver;
RX PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014;
RA Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L.,
RA Ye M., Zou H.;
RT "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver
RT phosphoproteome.";
RL J. Proteomics 96:253-262(2014).
CC -!- SIMILARITY: Belongs to the FAM89 family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AL732414; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC009447; AAH09447.1; -; mRNA.
DR CCDS; CCDS1590.1; -.
DR RefSeq; NP_940954.1; NM_198552.2.
DR AlphaFoldDB; Q96GI7; -.
DR SMR; Q96GI7; -.
DR BioGRID; 131954; 5.
DR IntAct; Q96GI7; 2.
DR STRING; 9606.ENSP00000355614; -.
DR iPTMnet; Q96GI7; -.
DR PhosphoSitePlus; Q96GI7; -.
DR BioMuta; FAM89A; -.
DR EPD; Q96GI7; -.
DR jPOST; Q96GI7; -.
DR MassIVE; Q96GI7; -.
DR MaxQB; Q96GI7; -.
DR PaxDb; Q96GI7; -.
DR PeptideAtlas; Q96GI7; -.
DR PRIDE; Q96GI7; -.
DR ProteomicsDB; 76636; -.
DR Antibodypedia; 68454; 8 antibodies from 4 providers.
DR DNASU; 375061; -.
DR Ensembl; ENST00000366654.5; ENSP00000355614.4; ENSG00000182118.8.
DR GeneID; 375061; -.
DR KEGG; hsa:375061; -.
DR MANE-Select; ENST00000366654.5; ENSP00000355614.4; NM_198552.3; NP_940954.1.
DR UCSC; uc001hui.3; human.
DR CTD; 375061; -.
DR DisGeNET; 375061; -.
DR GeneCards; FAM89A; -.
DR HGNC; HGNC:25057; FAM89A.
DR HPA; ENSG00000182118; Tissue enhanced (adipose tissue, placenta).
DR neXtProt; NX_Q96GI7; -.
DR OpenTargets; ENSG00000182118; -.
DR PharmGKB; PA142671794; -.
DR VEuPathDB; HostDB:ENSG00000182118; -.
DR eggNOG; ENOG502S28T; Eukaryota.
DR GeneTree; ENSGT00940000153370; -.
DR HOGENOM; CLU_128818_1_1_1; -.
DR InParanoid; Q96GI7; -.
DR OMA; MMENGFF; -.
DR OrthoDB; 1585340at2759; -.
DR PhylomeDB; Q96GI7; -.
DR PathwayCommons; Q96GI7; -.
DR SignaLink; Q96GI7; -.
DR BioGRID-ORCS; 375061; 9 hits in 1081 CRISPR screens.
DR ChiTaRS; FAM89A; human.
DR GenomeRNAi; 375061; -.
DR Pharos; Q96GI7; Tdark.
DR PRO; PR:Q96GI7; -.
DR Proteomes; UP000005640; Chromosome 1.
DR RNAct; Q96GI7; protein.
DR Bgee; ENSG00000182118; Expressed in placenta and 96 other tissues.
DR Genevisible; Q96GI7; HS.
PE 1: Evidence at protein level;
KW Reference proteome.
FT CHAIN 1..184
FT /note="Protein FAM89A"
FT /id="PRO_0000271761"
FT REGION 148..184
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 149..165
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 169..184
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 184 AA; 19569 MW; E727C153156C0004 CRC64;
MSGARAAPGA AGNGAVRGLR VDGLPPLPKS LSGLLHSASG GGASGGWRHL ERLYAQKSRI
QDELSRGGPG GGGARAAALP AKPPNLDAAL ALLRKEMVGL RQLDMSLLCQ LYSLYESIQE
YKGACQAASS PDCTYALENG FFDEEEEYFQ EQNSLHDRRD RGPPRDLSLP VSSLSSSDWI
LESI
