FA98A_HUMAN
ID FA98A_HUMAN Reviewed; 518 AA.
AC Q8NCA5; B2RNA2; Q9Y3Y6;
DT 06-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT 03-JUL-2019, sequence version 2.
DT 03-AUG-2022, entry version 143.
DE RecName: Full=Protein FAM98A {ECO:0000305};
GN Name=FAM98A {ECO:0000312|HGNC:HGNC:24520};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15815621; DOI=10.1038/nature03466;
RA Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P.,
RA Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C.,
RA Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L.,
RA Du H., Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A.,
RA Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J.,
RA Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M.,
RA Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T.,
RA Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S.,
RA Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S.,
RA Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C.,
RA Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M.,
RA Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C.,
RA Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J.,
RA Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E.,
RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X.,
RA Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M.,
RA Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H.,
RA Wilson R.K.;
RT "Generation and annotation of the DNA sequences of human chromosomes 2 and
RT 4.";
RL Nature 434:724-731(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 206-518.
RC TISSUE=Brain;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
RN [6]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T.,
RA Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
RN [7]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Liver;
RX PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014;
RA Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L.,
RA Ye M., Zou H.;
RT "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver
RT phosphoproteome.";
RL J. Proteomics 96:253-262(2014).
RN [8]
RP FUNCTION, INTERACTION WITH C14ORF166; DDX1 AND FAM98B, AND TISSUE
RP SPECIFICITY.
RX PubMed=28040436; DOI=10.1016/j.biocel.2016.12.013;
RA Akter K.A., Mansour M.A., Hyodo T., Senga T.;
RT "FAM98A associates with DDX1-C14orf166-FAM98B in a novel complex involved
RT in colorectal cancer progression.";
RL Int. J. Biochem. Cell Biol. 84:1-13(2017).
CC -!- FUNCTION: Positively stimulates PRMT1-induced protein arginine
CC methylation (PubMed:28040436). Involved in skeletal homeostasis (By
CC similarity). Positively regulates lysosome peripheral distribution and
CC ruffled border formation in osteoclasts (By similarity). Promotes
CC colorectal cancer cell malignancy (PubMed:28040436).
CC {ECO:0000250|UniProtKB:Q3TJZ6, ECO:0000269|PubMed:28040436}.
CC -!- SUBUNIT: Interacts (via N- and C-terminus) with DDX1 (PubMed:28040436).
CC Interacts (via N- and C-terminus) with C14orf166 (PubMed:28040436).
CC Interacts with FAM98B (PubMed:28040436). Interacts with PLEKHM1 (via
CC N- and C-terminus) (By similarity). {ECO:0000250|UniProtKB:Q3TJZ6,
CC ECO:0000269|PubMed:28040436}.
CC -!- INTERACTION:
CC Q8NCA5; Q92499: DDX1; NbExp=4; IntAct=EBI-1210765, EBI-358474;
CC Q8NCA5; Q9Y224: RTRAF; NbExp=7; IntAct=EBI-1210765, EBI-1104547;
CC -!- TISSUE SPECIFICITY: Expressed strongly in colorectal cancer cells
CC (PubMed:28040436). Expressed strongly in colorectal cancer tissues
CC compared to wild-type colon samples (at protein level)
CC (PubMed:28040436). Expressed strongly in colorectal cancer tissues
CC compared to wild-type colon samples (PubMed:28040436).
CC {ECO:0000269|PubMed:28040436}.
CC -!- SIMILARITY: Belongs to the FAM98 family. {ECO:0000305}.
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DR EMBL; AK074867; BAC11255.1; -; mRNA.
DR EMBL; AC017050; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471053; EAX00431.1; -; Genomic_DNA.
DR EMBL; BC136768; AAI36769.1; -; mRNA.
DR EMBL; BC136770; AAI36771.1; -; mRNA.
DR EMBL; AL049943; CAB43217.2; -; mRNA.
DR CCDS; CCDS33179.1; -.
DR PIR; T08675; T08675.
DR RefSeq; NP_056290.3; NM_015475.4.
DR AlphaFoldDB; Q8NCA5; -.
DR BioGRID; 117437; 199.
DR ComplexPortal; CPX-6411; tRNA-splicing ligase complex.
DR IntAct; Q8NCA5; 54.
DR MINT; Q8NCA5; -.
DR STRING; 9606.ENSP00000238823; -.
DR GlyGen; Q8NCA5; 1 site, 1 O-linked glycan (1 site).
DR iPTMnet; Q8NCA5; -.
DR MetOSite; Q8NCA5; -.
DR PhosphoSitePlus; Q8NCA5; -.
DR SwissPalm; Q8NCA5; -.
DR BioMuta; FAM98A; -.
DR DMDM; 74715180; -.
DR EPD; Q8NCA5; -.
DR jPOST; Q8NCA5; -.
DR MassIVE; Q8NCA5; -.
DR MaxQB; Q8NCA5; -.
DR PaxDb; Q8NCA5; -.
DR PeptideAtlas; Q8NCA5; -.
DR PRIDE; Q8NCA5; -.
DR Antibodypedia; 29272; 108 antibodies from 18 providers.
DR DNASU; 25940; -.
DR Ensembl; ENST00000238823.13; ENSP00000238823.8; ENSG00000119812.20.
DR GeneID; 25940; -.
DR KEGG; hsa:25940; -.
DR MANE-Select; ENST00000238823.13; ENSP00000238823.8; NM_015475.5; NP_056290.3.
DR UCSC; uc002rpa.2; human.
DR CTD; 25940; -.
DR DisGeNET; 25940; -.
DR GeneCards; FAM98A; -.
DR HGNC; HGNC:24520; FAM98A.
DR HPA; ENSG00000119812; Low tissue specificity.
DR neXtProt; NX_Q8NCA5; -.
DR OpenTargets; ENSG00000119812; -.
DR PharmGKB; PA142671777; -.
DR VEuPathDB; HostDB:ENSG00000119812; -.
DR eggNOG; KOG3973; Eukaryota.
DR GeneTree; ENSGT00440000037341; -.
DR HOGENOM; CLU_038408_1_2_1; -.
DR InParanoid; Q8NCA5; -.
DR OMA; GGWHQER; -.
DR PhylomeDB; Q8NCA5; -.
DR TreeFam; TF320308; -.
DR PathwayCommons; Q8NCA5; -.
DR SignaLink; Q8NCA5; -.
DR BioGRID-ORCS; 25940; 19 hits in 1085 CRISPR screens.
DR ChiTaRS; FAM98A; human.
DR GenomeRNAi; 25940; -.
DR Pharos; Q8NCA5; Tdark.
DR PRO; PR:Q8NCA5; -.
DR Proteomes; UP000005640; Chromosome 2.
DR RNAct; Q8NCA5; protein.
DR Bgee; ENSG00000119812; Expressed in tibia and 213 other tissues.
DR ExpressionAtlas; Q8NCA5; baseline and differential.
DR Genevisible; Q8NCA5; HS.
DR GO; GO:0005737; C:cytoplasm; IC:ComplexPortal.
DR GO; GO:0005634; C:nucleus; IC:ComplexPortal.
DR GO; GO:0072669; C:tRNA-splicing ligase complex; IBA:GO_Central.
DR GO; GO:0008276; F:protein methyltransferase activity; IMP:UniProtKB.
DR GO; GO:0003723; F:RNA binding; HDA:UniProtKB.
DR GO; GO:0032418; P:lysosome localization; ISS:UniProtKB.
DR GO; GO:0008284; P:positive regulation of cell population proliferation; IMP:UniProtKB.
DR GO; GO:0010628; P:positive regulation of gene expression; IMP:UniProtKB.
DR GO; GO:1900029; P:positive regulation of ruffle assembly; ISS:UniProtKB.
DR GO; GO:0006479; P:protein methylation; IMP:UniProtKB.
DR GO; GO:0006388; P:tRNA splicing, via endonucleolytic cleavage and ligation; IC:ComplexPortal.
DR InterPro; IPR018797; FAM98.
DR PANTHER; PTHR31353; PTHR31353; 1.
DR Pfam; PF10239; DUF2465; 1.
PE 1: Evidence at protein level;
KW Reference proteome.
FT CHAIN 1..518
FT /note="Protein FAM98A"
FT /id="PRO_0000187184"
FT REGION 297..415
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 434..518
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 309..323
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 449..463
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 486..518
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 174
FT /note="K -> KK (in Ref. 1; BAC11255)"
FT /evidence="ECO:0000305"
FT CONFLICT 337
FT /note="G -> V (in Ref. 5; CAB43217)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 518 AA; 55273 MW; BED845DFE305060D CRC64;
MECDLMETDI LESLEDLGYK GPLLEDGALS QAVSAGASSP EFTKLCAWLV SELRVLCKLE
ENVQATNSPS EAEEFQLEVS GLLGEMNCPY LSLTSGDVTK RLLIQKNCLL LLTYLISELE
AARMLCVNAP PKKAQEGGGS EVFQELKGIC IALGMSKPPA NITMFQFFSG IEKKLKETLA
KVPPNHVGKP LLKKPMGPAH WEKIEAINQA IANEYEVRRK LLIKRLDVTV QSFGWSDRAK
SQTEKLAKVY QPKRSVLSPK TTISVAHLLA ARQDLSKILR TSSGSIREKT ACAINKVLMG
RVPDRGGRPN EIEPPPPEMP PWQKRQDGPQ QQTGGRGGGR GGYEHSSYGG RGGHEQGGGR
GGRGGYDHGG RGGGRGNKHQ GGWTDGGSGG GGGYQDGGYR DSGFQPGGYH GGHSSGGYQG
GGYGGFQTSS SYTGSGYQGG GYQQDNRYQD GGHHGDRGGG RGGRGGRGGR GGRAGQGGGW
GGRGSQNYHQ GGQFEQHFQH GGYQYNHSGF GQGRHYTS
