FA98A_MOUSE
ID FA98A_MOUSE Reviewed; 515 AA.
AC Q3TJZ6; Q99KJ2;
DT 06-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT 11-OCT-2005, sequence version 1.
DT 03-AUG-2022, entry version 117.
DE RecName: Full=Protein FAM98A {ECO:0000305};
GN Name=Fam98a {ECO:0000312|MGI:MGI:1919972};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=FVB/N; TISSUE=Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brown adipose tissue, Heart, Kidney, Liver, Lung, Pancreas, Spleen,
RC and Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
RN [4]
RP FUNCTION, AND INTERACTION WITH PLEKHM1.
RX PubMed=27777970; DOI=10.1172/jci.insight.86330;
RA Fujiwara T., Ye S., Castro-Gomes T., Winchell C.G., Andrews N.W.,
RA Voth D.E., Varughese K.I., Mackintosh S.G., Feng Y., Pavlos N.,
RA Nakamura T., Manolagas S.C., Zhao H.;
RT "PLEKHM1/DEF8/RAB7 complex regulates lysosome positioning and bone
RT homeostasis.";
RL JCI Insight 1:E86330-E86330(2016).
CC -!- FUNCTION: Positively stimulates PRMT1-induced protein arginine
CC methylation (By similarity). Involved in skeletal homeostasis
CC (PubMed:27777970). Positively regulates lysosome peripheral
CC distribution and ruffled border formation in osteoclasts
CC (PubMed:27777970). {ECO:0000250|UniProtKB:Q8NCA5,
CC ECO:0000269|PubMed:27777970}.
CC -!- SUBUNIT: Interacts (via N- and C-terminus) with DDX1 (By similarity).
CC Interacts (via N- and C-terminus) with C14orf166 (By similarity).
CC Interacts with FAM98B (By similarity). Interacts with PLEKHM1 (via
CC N- and C-terminus) (PubMed:27777970). {ECO:0000250|UniProtKB:Q8NCA5,
CC ECO:0000269|PubMed:27777970}.
CC -!- SIMILARITY: Belongs to the FAM98 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH04626.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AK167224; BAE39349.1; -; mRNA.
DR EMBL; BC004626; AAH04626.1; ALT_INIT; mRNA.
DR CCDS; CCDS28974.2; -.
DR RefSeq; NP_598508.2; NM_133747.2.
DR AlphaFoldDB; Q3TJZ6; -.
DR BioGRID; 215533; 13.
DR IntAct; Q3TJZ6; 5.
DR MINT; Q3TJZ6; -.
DR STRING; 10090.ENSMUSP00000108126; -.
DR iPTMnet; Q3TJZ6; -.
DR PhosphoSitePlus; Q3TJZ6; -.
DR SwissPalm; Q3TJZ6; -.
DR EPD; Q3TJZ6; -.
DR jPOST; Q3TJZ6; -.
DR MaxQB; Q3TJZ6; -.
DR PaxDb; Q3TJZ6; -.
DR PeptideAtlas; Q3TJZ6; -.
DR PRIDE; Q3TJZ6; -.
DR ProteomicsDB; 271851; -.
DR Antibodypedia; 29272; 108 antibodies from 18 providers.
DR Ensembl; ENSMUST00000112507; ENSMUSP00000108126; ENSMUSG00000002017.
DR GeneID; 72722; -.
DR KEGG; mmu:72722; -.
DR UCSC; uc008doq.1; mouse.
DR CTD; 25940; -.
DR MGI; MGI:1919972; Fam98a.
DR VEuPathDB; HostDB:ENSMUSG00000002017; -.
DR eggNOG; KOG3973; Eukaryota.
DR GeneTree; ENSGT00440000037341; -.
DR HOGENOM; CLU_038408_1_2_1; -.
DR InParanoid; Q3TJZ6; -.
DR OMA; GGWHQER; -.
DR OrthoDB; 800008at2759; -.
DR PhylomeDB; Q3TJZ6; -.
DR BioGRID-ORCS; 72722; 0 hits in 75 CRISPR screens.
DR ChiTaRS; Fam98a; mouse.
DR PRO; PR:Q3TJZ6; -.
DR Proteomes; UP000000589; Chromosome 17.
DR RNAct; Q3TJZ6; protein.
DR Bgee; ENSMUSG00000002017; Expressed in saccule of membranous labyrinth and 259 other tissues.
DR ExpressionAtlas; Q3TJZ6; baseline and differential.
DR Genevisible; Q3TJZ6; MM.
DR GO; GO:0072669; C:tRNA-splicing ligase complex; IBA:GO_Central.
DR GO; GO:0008276; F:protein methyltransferase activity; ISS:UniProtKB.
DR GO; GO:0032418; P:lysosome localization; IMP:UniProtKB.
DR GO; GO:0008284; P:positive regulation of cell population proliferation; ISS:UniProtKB.
DR GO; GO:0010628; P:positive regulation of gene expression; ISS:UniProtKB.
DR GO; GO:1900029; P:positive regulation of ruffle assembly; IMP:UniProtKB.
DR GO; GO:0006479; P:protein methylation; ISS:UniProtKB.
DR InterPro; IPR018797; FAM98.
DR PANTHER; PTHR31353; PTHR31353; 1.
DR Pfam; PF10239; DUF2465; 1.
PE 1: Evidence at protein level;
KW Reference proteome.
FT CHAIN 1..515
FT /note="Protein FAM98A"
FT /id="PRO_0000187185"
FT REGION 297..410
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 432..515
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 309..323
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 446..460
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 477..515
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 515 AA; 55055 MW; FB985739E8F3270B CRC64;
MECDLMETDI LESLEDLGYK GPLLDDGALL QAVSAGAASP EFTKLCAWLV SELRVLCKLE
ENVQATNSPS EAEEFQLEVS GLLGEMNCPY PSLTSGDVTK RLLVEKNCLL LLTYLISELE
AARMLCVNAP PKKAQEGGGS EVFQELKGIC IALGMSKPPA NITMFQFFSG IEKKLKETLA
KVPPNHVGKP LLKKPMGPAH WEKIEAINQA IANEYEVRRK LLIKRLDVTV QSFGWSDRAK
SQTDKLAKVY QPKRSLLSPK GKVSVAHLLA ARQDLSKILR TSSGSIREKT ACAINKVLMG
RVPDRGGRPN EIEPPPPEMP PWQKRQDGPQ QQAGGRGGGR GGYEHSSYGG RGGHEQGGRG
GRGSYDHGGR GGGRGNKHQG GWTDGGSGSG GGYQDGAYRD SGFQPGGYHG GHSGGYQAGG
YGGFQTSSYT GSGYQGGGYQ QDNRYQDGGH HGERGSGRGG RGGRGGRGGR GSQGGGWGGR
GSQTYHQGGQ FEQHFQHGGY QYSHSGFGQG RHYTS
