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FA98A_PONAB
ID   FA98A_PONAB             Reviewed;         518 AA.
AC   Q5R679;
DT   06-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT   21-DEC-2004, sequence version 1.
DT   25-MAY-2022, entry version 44.
DE   RecName: Full=Protein FAM98A {ECO:0000250|UniProtKB:Q8NCA5};
GN   Name=FAM98A {ECO:0000250|UniProtKB:Q8NCA5};
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9601;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain cortex;
RG   The German cDNA consortium;
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Positively stimulates PRMT1-induced protein arginine
CC       methylation. Involved in skeletal homeostasis. Positively regulates
CC       lysosome peripheral distribution and ruffled border formation in
CC       osteoclasts. {ECO:0000250|UniProtKB:Q3TJZ6,
CC       ECO:0000250|UniProtKB:Q8NCA5}.
CC   -!- SUBUNIT: Interacts (via N- and C-terminus) with DDX1. Interacts (via
CC       N- and C-terminus) with C14orf166. Interacts with FAM98B. Interacts
CC       with PLEKHM1 (via N- and C-terminus). {ECO:0000250|UniProtKB:Q3TJZ6,
CC       ECO:0000250|UniProtKB:Q8NCA5}.
CC   -!- SIMILARITY: Belongs to the FAM98 family. {ECO:0000305}.
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DR   EMBL; CR860616; CAH92737.1; -; mRNA.
DR   RefSeq; NP_001126597.1; NM_001133125.1.
DR   AlphaFoldDB; Q5R679; -.
DR   STRING; 9601.ENSPPYP00000013960; -.
DR   GeneID; 100173593; -.
DR   KEGG; pon:100173593; -.
DR   CTD; 25940; -.
DR   eggNOG; KOG3973; Eukaryota.
DR   InParanoid; Q5R679; -.
DR   OrthoDB; 800008at2759; -.
DR   Proteomes; UP000001595; Unplaced.
DR   GO; GO:0008276; F:protein methyltransferase activity; ISS:UniProtKB.
DR   GO; GO:0032418; P:lysosome localization; ISS:UniProtKB.
DR   GO; GO:0008284; P:positive regulation of cell population proliferation; ISS:UniProtKB.
DR   GO; GO:0010628; P:positive regulation of gene expression; ISS:UniProtKB.
DR   GO; GO:1900029; P:positive regulation of ruffle assembly; ISS:UniProtKB.
DR   GO; GO:0006479; P:protein methylation; ISS:UniProtKB.
DR   InterPro; IPR018797; FAM98.
DR   PANTHER; PTHR31353; PTHR31353; 1.
DR   Pfam; PF10239; DUF2465; 1.
PE   2: Evidence at transcript level;
KW   Reference proteome.
FT   CHAIN           1..518
FT                   /note="Protein FAM98A"
FT                   /id="PRO_0000187186"
FT   REGION          300..415
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          434..518
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        309..323
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        449..463
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        486..518
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   518 AA;  55160 MW;  89CDD294750367A2 CRC64;
     MECDLMETDI LESLEDLGYK GPLLEDGALS QAVSAGASSP EFTKLCAWLV SELRVLCKLE
     ENVQATNSPS EAEEFQLEVS GLLGEMNCPY LSLTSGDVTK RLLIQKNCLL LLTYLISELE
     AARMLCVNAP PKKAQEGGGS EVFQELEGIC IALGMSKPPA NITMFQFFSG IEKKLKETLA
     KVPPNHVGKP LLKKPMGPAH WEKIEAINQA IANEYEVRRK LLIKRLDVTV QSFGWSDRAK
     SQTEKLAKVY QPKRSVLSPK STISVAHLLA ARQDLSKILR TSSGSIGEKT ACAINKVLMG
     RVPDRGGRPN EIEPPPPEMP PWQKRQDGPQ QQTGGRGGGR GGYEHSSYGG RGGHEQGGGR
     GGRGGYDHGG RGGGRGNKHQ GGWTDGGSGG GGGYQDGGYR DSGFQPGGYH GGHSSGGYQG
     GGYGGFQTSS SYTGSGYQGG GYQQDNRYQD GGHHGDRGGG RGGRGGRGGR GGRAGQGGGW
     GGRGSQNYHQ GGQFEQHFQH GGYQYNHSGF GQGRHYTS
 
 
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