FA98A_PONAB
ID FA98A_PONAB Reviewed; 518 AA.
AC Q5R679;
DT 06-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT 21-DEC-2004, sequence version 1.
DT 25-MAY-2022, entry version 44.
DE RecName: Full=Protein FAM98A {ECO:0000250|UniProtKB:Q8NCA5};
GN Name=FAM98A {ECO:0000250|UniProtKB:Q8NCA5};
OS Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pongo.
OX NCBI_TaxID=9601;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain cortex;
RG The German cDNA consortium;
RL Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Positively stimulates PRMT1-induced protein arginine
CC methylation. Involved in skeletal homeostasis. Positively regulates
CC lysosome peripheral distribution and ruffled border formation in
CC osteoclasts. {ECO:0000250|UniProtKB:Q3TJZ6,
CC ECO:0000250|UniProtKB:Q8NCA5}.
CC -!- SUBUNIT: Interacts (via N- and C-terminus) with DDX1. Interacts (via
CC N- and C-terminus) with C14orf166. Interacts with FAM98B. Interacts
CC with PLEKHM1 (via N- and C-terminus). {ECO:0000250|UniProtKB:Q3TJZ6,
CC ECO:0000250|UniProtKB:Q8NCA5}.
CC -!- SIMILARITY: Belongs to the FAM98 family. {ECO:0000305}.
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DR EMBL; CR860616; CAH92737.1; -; mRNA.
DR RefSeq; NP_001126597.1; NM_001133125.1.
DR AlphaFoldDB; Q5R679; -.
DR STRING; 9601.ENSPPYP00000013960; -.
DR GeneID; 100173593; -.
DR KEGG; pon:100173593; -.
DR CTD; 25940; -.
DR eggNOG; KOG3973; Eukaryota.
DR InParanoid; Q5R679; -.
DR OrthoDB; 800008at2759; -.
DR Proteomes; UP000001595; Unplaced.
DR GO; GO:0008276; F:protein methyltransferase activity; ISS:UniProtKB.
DR GO; GO:0032418; P:lysosome localization; ISS:UniProtKB.
DR GO; GO:0008284; P:positive regulation of cell population proliferation; ISS:UniProtKB.
DR GO; GO:0010628; P:positive regulation of gene expression; ISS:UniProtKB.
DR GO; GO:1900029; P:positive regulation of ruffle assembly; ISS:UniProtKB.
DR GO; GO:0006479; P:protein methylation; ISS:UniProtKB.
DR InterPro; IPR018797; FAM98.
DR PANTHER; PTHR31353; PTHR31353; 1.
DR Pfam; PF10239; DUF2465; 1.
PE 2: Evidence at transcript level;
KW Reference proteome.
FT CHAIN 1..518
FT /note="Protein FAM98A"
FT /id="PRO_0000187186"
FT REGION 300..415
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 434..518
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 309..323
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 449..463
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 486..518
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 518 AA; 55160 MW; 89CDD294750367A2 CRC64;
MECDLMETDI LESLEDLGYK GPLLEDGALS QAVSAGASSP EFTKLCAWLV SELRVLCKLE
ENVQATNSPS EAEEFQLEVS GLLGEMNCPY LSLTSGDVTK RLLIQKNCLL LLTYLISELE
AARMLCVNAP PKKAQEGGGS EVFQELEGIC IALGMSKPPA NITMFQFFSG IEKKLKETLA
KVPPNHVGKP LLKKPMGPAH WEKIEAINQA IANEYEVRRK LLIKRLDVTV QSFGWSDRAK
SQTEKLAKVY QPKRSVLSPK STISVAHLLA ARQDLSKILR TSSGSIGEKT ACAINKVLMG
RVPDRGGRPN EIEPPPPEMP PWQKRQDGPQ QQTGGRGGGR GGYEHSSYGG RGGHEQGGGR
GGRGGYDHGG RGGGRGNKHQ GGWTDGGSGG GGGYQDGGYR DSGFQPGGYH GGHSSGGYQG
GGYGGFQTSS SYTGSGYQGG GYQQDNRYQD GGHHGDRGGG RGGRGGRGGR GGRAGQGGGW
GGRGSQNYHQ GGQFEQHFQH GGYQYNHSGF GQGRHYTS