ID   FA98A_RAT               Reviewed;         515 AA.
AC   Q5FWT1;
DT   06-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2005, sequence version 1.
DT   03-AUG-2022, entry version 91.
DE   RecName: Full=Protein FAM98A {ECO:0000305};
GN   Name=Fam98a {ECO:0000312|RGD:1305486};
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Ovary;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Positively stimulates PRMT1-induced protein arginine
CC       methylation. Involved in skeletal homeostasis. Positively regulates
CC       lysosome peripheral distribution and ruffled border formation in
CC       osteoclasts. {ECO:0000250|UniProtKB:Q3TJZ6,
CC       ECO:0000250|UniProtKB:Q8NCA5}.
CC   -!- SUBUNIT: Interacts (via N- and C-terminus) with DDX1. Interacts (via
CC       N- and C-terminus) with C14orf166. Interacts with FAM98B. Interacts
CC       with PLEKHM1 (via N- and C-terminus). {ECO:0000250|UniProtKB:Q3TJZ6,
CC       ECO:0000250|UniProtKB:Q8NCA5}.
CC   -!- SIMILARITY: Belongs to the FAM98 family. {ECO:0000305}.
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DR   EMBL; BC089217; AAH89217.1; -; mRNA.
DR   RefSeq; NP_001014095.1; NM_001014073.1.
DR   AlphaFoldDB; Q5FWT1; -.
DR   BioGRID; 260572; 2.
DR   IntAct; Q5FWT1; 3.
DR   MINT; Q5FWT1; -.
DR   STRING; 10116.ENSRNOP00000042004; -.
DR   iPTMnet; Q5FWT1; -.
DR   PhosphoSitePlus; Q5FWT1; -.
DR   jPOST; Q5FWT1; -.
DR   PaxDb; Q5FWT1; -.
DR   PRIDE; Q5FWT1; -.
DR   GeneID; 313873; -.
DR   KEGG; rno:313873; -.
DR   UCSC; RGD:1305486; rat.
DR   CTD; 25940; -.
DR   RGD; 1305486; Fam98a.
DR   VEuPathDB; HostDB:ENSRNOG00000030328; -.
DR   eggNOG; KOG3973; Eukaryota.
DR   HOGENOM; CLU_038408_1_2_1; -.
DR   InParanoid; Q5FWT1; -.
DR   OMA; GGWHQER; -.
DR   OrthoDB; 800008at2759; -.
DR   PhylomeDB; Q5FWT1; -.
DR   PRO; PR:Q5FWT1; -.
DR   Proteomes; UP000002494; Chromosome 6.
DR   Bgee; ENSRNOG00000030328; Expressed in testis and 20 other tissues.
DR   Genevisible; Q5FWT1; RN.
DR   GO; GO:0072669; C:tRNA-splicing ligase complex; IBA:GO_Central.
DR   GO; GO:0008276; F:protein methyltransferase activity; ISS:UniProtKB.
DR   GO; GO:0032418; P:lysosome localization; ISS:UniProtKB.
DR   GO; GO:0008284; P:positive regulation of cell population proliferation; ISS:UniProtKB.
DR   GO; GO:0010628; P:positive regulation of gene expression; ISS:UniProtKB.
DR   GO; GO:1900029; P:positive regulation of ruffle assembly; ISS:UniProtKB.
DR   GO; GO:0006479; P:protein methylation; ISS:UniProtKB.
DR   InterPro; IPR018797; FAM98.
DR   PANTHER; PTHR31353; PTHR31353; 1.
DR   Pfam; PF10239; DUF2465; 1.
PE   2: Evidence at transcript level;
KW   Reference proteome.
FT   CHAIN           1..515
FT                   /note="Protein FAM98A"
FT                   /id="PRO_0000187187"
FT   REGION          297..411
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          432..515
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        309..323
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        446..460
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        477..515
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   515 AA;  55070 MW;  8A9C0E162D58B3B9 CRC64;
     MECDLMETDI LESLEDLGYK GPLLDDGALL QAVSAGAASP EFTKLCAWLV SELRVLCKLE
     ENVQATNSPS EAEEFQLEVS GLLGEMNCPY PCLTSGDVTK RLLVQKNCLL LLTYLISELE
     AARMLCVNAP PKKAQEGGGS EVFQELKGIC IALGMSKPPA NITMFQFFSG IEKKLKETLA
     KVPPNHVGKP LLKKSMGPAH WEKIEAINQA IANEYEVRRK LLIKRLDVTV QSFGWSDRAK
     SQTEKLAKVY QPKRSVLSPK GNISIAHLLA ARQDLSKILR TSSGSIREKT ACAINKVLMG
     RVPDRGGRPN EIEPPPPEMP PWQKRQDGPQ QQAGGRGGGR GGYEHSSYGG RGGHEQGGRG
     GRGGYDHGGR GGGRGNKHQG GWTDGGSASG GGYQDGGYRD PGFQPGGYHG GHSSGYQGGG
     YGGFQTSSYT GSGYQGGGYQ QDNRYQDGGH HGERGSGRGG RGGRGGRGGR GSQGGGWGGR
     GSQTYHQGGQ FEQHFQHGGY QYSHSGFGQG RHYTS