FA98B_MOUSE
ID FA98B_MOUSE Reviewed; 429 AA.
AC Q80VD1; A2ATZ4; Q9CS28; Q9CS37;
DT 06-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2003, sequence version 1.
DT 03-AUG-2022, entry version 121.
DE RecName: Full=Protein FAM98B;
GN Name=Fam98b;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=FVB/N-3; TISSUE=Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-129.
RC STRAIN=C57BL/6J;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [4]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain, Kidney, Liver, Lung, Pancreas, Spleen, and Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: Positively stimulates PRMT1-induced protein arginine
CC dimethylated arginine methylation. {ECO:0000250|UniProtKB:Q52LJ0}.
CC -!- SUBUNIT: Homodimer. Component of a tRNA-splicing ligase complex.
CC Interacts with FAM98A. {ECO:0000250|UniProtKB:Q52LJ0}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q52LJ0}. Cytoplasm
CC {ECO:0000250|UniProtKB:Q52LJ0}.
CC -!- SIMILARITY: Belongs to the FAM98 family. {ECO:0000305}.
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DR EMBL; AL928959; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC048087; AAH48087.1; -; mRNA.
DR EMBL; AK019190; BAB31594.1; -; mRNA.
DR EMBL; AK019253; BAB31629.1; -; mRNA.
DR CCDS; CCDS16571.1; -.
DR RefSeq; NP_080896.2; NM_026620.3.
DR AlphaFoldDB; Q80VD1; -.
DR SMR; Q80VD1; -.
DR BioGRID; 212735; 10.
DR IntAct; Q80VD1; 2.
DR STRING; 10090.ENSMUSP00000028825; -.
DR iPTMnet; Q80VD1; -.
DR PhosphoSitePlus; Q80VD1; -.
DR EPD; Q80VD1; -.
DR jPOST; Q80VD1; -.
DR MaxQB; Q80VD1; -.
DR PaxDb; Q80VD1; -.
DR PeptideAtlas; Q80VD1; -.
DR PRIDE; Q80VD1; -.
DR ProteomicsDB; 267701; -.
DR Antibodypedia; 2032; 106 antibodies from 20 providers.
DR DNASU; 68215; -.
DR Ensembl; ENSMUST00000028825; ENSMUSP00000028825; ENSMUSG00000027349.
DR GeneID; 68215; -.
DR KEGG; mmu:68215; -.
DR UCSC; uc008lrk.1; mouse.
DR CTD; 283742; -.
DR MGI; MGI:1915465; Fam98b.
DR VEuPathDB; HostDB:ENSMUSG00000027349; -.
DR eggNOG; KOG3973; Eukaryota.
DR GeneTree; ENSGT00440000037341; -.
DR HOGENOM; CLU_038408_1_0_1; -.
DR InParanoid; Q80VD1; -.
DR OMA; NDQQWIS; -.
DR OrthoDB; 800008at2759; -.
DR PhylomeDB; Q80VD1; -.
DR TreeFam; TF320308; -.
DR BioGRID-ORCS; 68215; 11 hits in 73 CRISPR screens.
DR PRO; PR:Q80VD1; -.
DR Proteomes; UP000000589; Chromosome 2.
DR RNAct; Q80VD1; protein.
DR Bgee; ENSMUSG00000027349; Expressed in manus and 216 other tissues.
DR Genevisible; Q80VD1; MM.
DR GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR GO; GO:0043231; C:intracellular membrane-bounded organelle; ISO:MGI.
DR GO; GO:0005654; C:nucleoplasm; ISO:MGI.
DR GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR GO; GO:0072669; C:tRNA-splicing ligase complex; ISS:UniProtKB.
DR GO; GO:0042802; F:identical protein binding; ISS:UniProtKB.
DR GO; GO:0008276; F:protein methyltransferase activity; ISS:UniProtKB.
DR GO; GO:0008284; P:positive regulation of cell population proliferation; ISS:UniProtKB.
DR GO; GO:0010628; P:positive regulation of gene expression; ISS:UniProtKB.
DR GO; GO:0006479; P:protein methylation; ISS:UniProtKB.
DR InterPro; IPR018797; FAM98.
DR PANTHER; PTHR31353; PTHR31353; 1.
DR Pfam; PF10239; DUF2465; 1.
PE 1: Evidence at protein level;
KW Cytoplasm; Nucleus; Reference proteome.
FT CHAIN 1..429
FT /note="Protein FAM98B"
FT /id="PRO_0000187189"
FT REGION 304..429
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 429 AA; 45349 MW; 776050E4A471F366 CRC64;
MRGPELGPET SMEGDVLDTL EALGYKGPLL EEQALSKAAE GGLSSPEFSE LCIWLGSQIK
SLCNLEESIT SAGRDDLESF QLEISGFLKE MACPYSVLVS GDIKERLTKK DDCLKLLLFL
STELQALQIL QKKKHKNSQL DKNSEICQEV QAVCDALGVP KSDTSDIPLL LSQVESKVKD
ILCRVQKNHV GKPLLKVDLS SEQAEKLERI NDALSCEYEC RRRMLMKRLD VTVQSFGWSD
RAKAKTDNIA RIYQPKRYAL SPKTTVTLAH LLAAREDLSK IIRTSSGISR EKTACAINKV
LMGRVPDRGG RPNEIEPPPP EMPPWQKRQE GGGRGGWGGG GGGRGGGGGG RGGWGGGGGW
GGGGGSGGGW GGSGGGGGGR GGFQGRGDYG GRGDYGGRGG YGGRGGYGGR GYGDPYGGGG
GGGGGYRRY
