ID   FAB1A_DANRE             Reviewed;         127 AA.
AC   Q1AMT3;
DT   05-OCT-2010, integrated into UniProtKB/Swiss-Prot.
DT   11-JUL-2006, sequence version 1.
DT   03-AUG-2022, entry version 106.
DE   RecName: Full=Fatty acid binding protein 1-A, liver {ECO:0000312|ZFIN:ZDB-GENE-020318-3};
GN   Name=fabp1a {ECO:0000312|ZFIN:ZDB-GENE-020318-3};
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1] {ECO:0000305, ECO:0000312|EMBL:AAZ08575.1}
RP   NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RX   PubMed=16857010; DOI=10.1111/j.1742-4658.2006.05330.x;
RA   Sharma M.K., Liu R.Z., Thisse C., Thisse B., Denovan-Wright E.M.,
RA   Wright J.M.;
RT   "Hierarchical subfunctionalization of fabp1a, fabp1b and fabp10 tissue-
RT   specific expression may account for retention of these duplicated genes in
RT   the zebrafish (Danio rerio) genome.";
RL   FEBS J. 273:3216-3229(2006).
RN   [2] {ECO:0000312|EMBL:AAI63809.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (APR-2008) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Binds free fatty acids and their coenzyme A derivatives,
CC       bilirubin, and some other small molecules in the cytoplasm. May be
CC       involved in intracellular lipid transport (By similarity).
CC       {ECO:0000250|UniProtKB:P07148}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P07148}.
CC   -!- TISSUE SPECIFICITY: In adults, weakly expressed in the intestine.
CC       {ECO:0000269|PubMed:16857010}.
CC   -!- DOMAIN: Forms a beta-barrel structure that accommodates hydrophobic
CC       ligands in its interior. {ECO:0000250|UniProtKB:P07148}.
CC   -!- SIMILARITY: Belongs to the calycin superfamily. Fatty-acid binding
CC       protein (FABP) family. {ECO:0000255}.
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DR   EMBL; DQ062095; AAZ08575.1; -; mRNA.
DR   EMBL; BC163809; AAI63809.1; -; mRNA.
DR   EMBL; BC163810; AAI63810.1; -; mRNA.
DR   RefSeq; NP_001038177.1; NM_001044712.1.
DR   AlphaFoldDB; Q1AMT3; -.
DR   SMR; Q1AMT3; -.
DR   STRING; 7955.ENSDARP00000003282; -.
DR   PaxDb; Q1AMT3; -.
DR   Ensembl; ENSDART00000006606; ENSDARP00000003282; ENSDARG00000019357.
DR   GeneID; 791610; -.
DR   KEGG; dre:791610; -.
DR   CTD; 791610; -.
DR   ZFIN; ZDB-GENE-020318-3; fabp1a.
DR   eggNOG; KOG4015; Eukaryota.
DR   GeneTree; ENSGT00940000155135; -.
DR   HOGENOM; CLU_113772_4_2_1; -.
DR   InParanoid; Q1AMT3; -.
DR   OMA; CELETFT; -.
DR   OrthoDB; 1440574at2759; -.
DR   PhylomeDB; Q1AMT3; -.
DR   TreeFam; TF330348; -.
DR   PRO; PR:Q1AMT3; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Chromosome 5.
DR   Bgee; ENSDARG00000019357; Expressed in hepatocyte and 8 other tissues.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0005504; F:fatty acid binding; ISS:ZFIN.
DR   GO; GO:0015908; P:fatty acid transport; IBA:GO_Central.
DR   Gene3D; 2.40.128.20; -; 1.
DR   InterPro; IPR012674; Calycin.
DR   InterPro; IPR000463; Fatty_acid-bd.
DR   InterPro; IPR031259; ILBP.
DR   InterPro; IPR031276; Lb-FABP.
DR   PANTHER; PTHR11955; PTHR11955; 1.
DR   PANTHER; PTHR11955:SF96; PTHR11955:SF96; 1.
DR   PRINTS; PR00178; FATTYACIDBP.
DR   SUPFAM; SSF50814; SSF50814; 1.
DR   PROSITE; PS00214; FABP; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Lipid-binding; Reference proteome; Transport.
FT   CHAIN           1..127
FT                   /note="Fatty acid binding protein 1-A, liver"
FT                   /id="PRO_0000397922"
SQ   SEQUENCE   127 AA;  14080 MW;  F0ABA37E7BD928C8 CRC64;
     MAFTGKYQLE SHENFEAFMK AVGVPDDEVE KGKDIKSISE IHQDGKDFKV TVTAGTKVIL
     YSFTVGEECE LETFTGDRAK TVVQMDGNKL TAFVKGIESV TELDGDTISN TLSFNGIVYK
     RISRRIS