ID   FABD_BUCAP              Reviewed;         310 AA.
AC   Q8K9J6;
DT   15-NOV-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2002, sequence version 1.
DT   03-AUG-2022, entry version 107.
DE   RecName: Full=Malonyl CoA-acyl carrier protein transacylase;
DE            Short=MCT;
DE            EC=2.3.1.39;
GN   Name=fabD; OrderedLocusNames=BUsg_338;
OS   Buchnera aphidicola subsp. Schizaphis graminum (strain Sg).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Erwiniaceae; Buchnera.
OX   NCBI_TaxID=198804;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Sg;
RX   PubMed=12089438; DOI=10.1126/science.1071278;
RA   Tamas I., Klasson L., Canbaeck B., Naeslund A.K., Eriksson A.-S.,
RA   Wernegreen J.J., Sandstroem J.P., Moran N.A., Andersson S.G.E.;
RT   "50 million years of genomic stasis in endosymbiotic bacteria.";
RL   Science 296:2376-2379(2002).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=holo-[ACP] + malonyl-CoA = CoA + malonyl-[ACP];
CC         Xref=Rhea:RHEA:41792, Rhea:RHEA-COMP:9623, Rhea:RHEA-COMP:9685,
CC         ChEBI:CHEBI:57287, ChEBI:CHEBI:57384, ChEBI:CHEBI:64479,
CC         ChEBI:CHEBI:78449; EC=2.3.1.39;
CC   -!- PATHWAY: Lipid metabolism; fatty acid biosynthesis.
CC   -!- SIMILARITY: Belongs to the FabD family. {ECO:0000305}.
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DR   EMBL; AE013218; AAM67892.1; -; Genomic_DNA.
DR   RefSeq; WP_011053859.1; NC_004061.1.
DR   AlphaFoldDB; Q8K9J6; -.
DR   SMR; Q8K9J6; -.
DR   STRING; 198804.BUsg_338; -.
DR   EnsemblBacteria; AAM67892; AAM67892; BUsg_338.
DR   KEGG; bas:BUsg_338; -.
DR   eggNOG; COG0331; Bacteria.
DR   HOGENOM; CLU_030558_0_0_6; -.
DR   OMA; AANYNCP; -.
DR   OrthoDB; 1123553at2; -.
DR   UniPathway; UPA00094; -.
DR   Proteomes; UP000000416; Chromosome.
DR   GO; GO:0004314; F:[acyl-carrier-protein] S-malonyltransferase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006633; P:fatty acid biosynthetic process; IEA:UniProtKB-UniPathway.
DR   Gene3D; 3.40.366.10; -; 1.
DR   InterPro; IPR001227; Ac_transferase_dom_sf.
DR   InterPro; IPR014043; Acyl_transferase.
DR   InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR   InterPro; IPR024925; Malonyl_CoA-ACP_transAc.
DR   InterPro; IPR004410; Malonyl_CoA-ACP_transAc_FabD.
DR   InterPro; IPR016036; Malonyl_transacylase_ACP-bd.
DR   Pfam; PF00698; Acyl_transf_1; 1.
DR   PIRSF; PIRSF000446; Mct; 1.
DR   SMART; SM00827; PKS_AT; 1.
DR   SUPFAM; SSF52151; SSF52151; 1.
DR   SUPFAM; SSF55048; SSF55048; 1.
DR   TIGRFAMs; TIGR00128; fabD; 1.
PE   3: Inferred from homology;
KW   Acyltransferase; Fatty acid biosynthesis; Fatty acid metabolism;
KW   Lipid biosynthesis; Lipid metabolism; Transferase.
FT   CHAIN           1..310
FT                   /note="Malonyl CoA-acyl carrier protein transacylase"
FT                   /id="PRO_0000194212"
FT   ACT_SITE        93
FT                   /evidence="ECO:0000250"
FT   ACT_SITE        201
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   310 AA;  35351 MW;  376559CB2CD16F85 CRC64;
     MNSFAMLFPG QGSQYKNMLS SFFQKKNNLF KKIFDEASEY VNYNLLNLIK NGAKKKRDDY
     KYIQSAILTS SIAIYQLWKE KNGRRPALMS GHSLGEYSAL VCANAIKFSD ALKIVKLRSK
     LMQKIIINKP SLVQAIIGLD KVIIKNICLQ YLPKIVSIAS INSDDQIIIS GEKLAVREVG
     LKCKKKGAKY VIKLNINTPI HSQLMKPVSE QIKYLLKSIK IKSPQIPVIN NVDVICEKNE
     KKIKKALVRQ FYSTVRWKEI IDLIKSKKIF TMLEIGPNKI LSNLIKKNDN ITVLNTNNLK
     NFLIAFKTIH