FABD_HAEIN
ID FABD_HAEIN Reviewed; 312 AA.
AC P43712;
DT 01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1995, sequence version 1.
DT 03-AUG-2022, entry version 126.
DE RecName: Full=Malonyl CoA-acyl carrier protein transacylase;
DE Short=MCT;
DE EC=2.3.1.39;
GN Name=fabD; OrderedLocusNames=HI_0156;
OS Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC Pasteurellaceae; Haemophilus.
OX NCBI_TaxID=71421;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 51907 / DSM 11121 / KW20 / Rd;
RX PubMed=7542800; DOI=10.1126/science.7542800;
RA Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F.,
RA Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M.,
RA McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D.,
RA Scott J.D., Shirley R., Liu L.-I., Glodek A., Kelley J.M., Weidman J.F.,
RA Phillips C.A., Spriggs T., Hedblom E., Cotton M.D., Utterback T.R.,
RA Hanna M.C., Nguyen D.T., Saudek D.M., Brandon R.C., Fine L.D.,
RA Fritchman J.L., Fuhrmann J.L., Geoghagen N.S.M., Gnehm C.L., McDonald L.A.,
RA Small K.V., Fraser C.M., Smith H.O., Venter J.C.;
RT "Whole-genome random sequencing and assembly of Haemophilus influenzae
RT Rd.";
RL Science 269:496-512(1995).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=holo-[ACP] + malonyl-CoA = CoA + malonyl-[ACP];
CC Xref=Rhea:RHEA:41792, Rhea:RHEA-COMP:9623, Rhea:RHEA-COMP:9685,
CC ChEBI:CHEBI:57287, ChEBI:CHEBI:57384, ChEBI:CHEBI:64479,
CC ChEBI:CHEBI:78449; EC=2.3.1.39;
CC -!- PATHWAY: Lipid metabolism; fatty acid biosynthesis.
CC -!- SIMILARITY: Belongs to the FabD family. {ECO:0000305}.
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DR EMBL; L42023; AAC21825.1; -; Genomic_DNA.
DR PIR; E64051; E64051.
DR RefSeq; NP_438326.1; NC_000907.1.
DR RefSeq; WP_005694437.1; NC_000907.1.
DR AlphaFoldDB; P43712; -.
DR SMR; P43712; -.
DR STRING; 71421.HI_0156; -.
DR EnsemblBacteria; AAC21825; AAC21825; HI_0156.
DR KEGG; hin:HI_0156; -.
DR PATRIC; fig|71421.8.peg.160; -.
DR eggNOG; COG0331; Bacteria.
DR HOGENOM; CLU_030558_0_0_6; -.
DR OMA; AANYNCP; -.
DR PhylomeDB; P43712; -.
DR BioCyc; HINF71421:G1GJ1-168-MON; -.
DR UniPathway; UPA00094; -.
DR Proteomes; UP000000579; Chromosome.
DR GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR GO; GO:0004314; F:[acyl-carrier-protein] S-malonyltransferase activity; IBA:GO_Central.
DR GO; GO:0006633; P:fatty acid biosynthetic process; IBA:GO_Central.
DR Gene3D; 3.40.366.10; -; 1.
DR InterPro; IPR001227; Ac_transferase_dom_sf.
DR InterPro; IPR014043; Acyl_transferase.
DR InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR InterPro; IPR024925; Malonyl_CoA-ACP_transAc.
DR InterPro; IPR004410; Malonyl_CoA-ACP_transAc_FabD.
DR InterPro; IPR016036; Malonyl_transacylase_ACP-bd.
DR Pfam; PF00698; Acyl_transf_1; 1.
DR PIRSF; PIRSF000446; Mct; 1.
DR SMART; SM00827; PKS_AT; 1.
DR SUPFAM; SSF52151; SSF52151; 1.
DR SUPFAM; SSF55048; SSF55048; 1.
DR TIGRFAMs; TIGR00128; fabD; 1.
PE 3: Inferred from homology;
KW Acyltransferase; Fatty acid biosynthesis; Fatty acid metabolism;
KW Lipid biosynthesis; Lipid metabolism; Reference proteome; Transferase.
FT CHAIN 1..312
FT /note="Malonyl CoA-acyl carrier protein transacylase"
FT /id="PRO_0000194216"
FT ACT_SITE 93
FT /evidence="ECO:0000250"
FT ACT_SITE 202
FT /evidence="ECO:0000250"
SQ SEQUENCE 312 AA; 33425 MW; 6261622B834AE878 CRC64;
MKKFAMVFPG QGSQTVGMLA DLATEYPIVI ETFKQASDAL GYDLWYLVQQ GPAEELNKTW
QTQPALLAAS VAIYRVWKEK FPQLKPEVMA GHSLGEYSAL VCAGVLDFQD AIKLVELRGK
LMQQAVPEGT GAMYAIIGLD NEAIINACKQ AEEGEVVSAV NFNSPGQVVI AGAKAAVERA
AALCKEAGAK RALPLAVSVP SHCALMKPAA EQLAVTLENI QINTPTISVL NNVDVKAETE
GTEIRTALVR QLYSPVRWTE TVEKMAQDGV LVLAEVGPGK VLNGLTKRIV GDLQAISVND
VASFNAVEEF LV
