FABD_SALTY
ID FABD_SALTY Reviewed; 309 AA.
AC O85140;
DT 30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2007, sequence version 3.
DT 03-AUG-2022, entry version 127.
DE RecName: Full=Malonyl CoA-acyl carrier protein transacylase;
DE Short=MCT;
DE EC=2.3.1.39;
GN Name=fabD; OrderedLocusNames=STM1194;
OS Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Salmonella.
OX NCBI_TaxID=99287;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=LT2;
RX PubMed=9642179; DOI=10.1128/jb.180.13.3295-3303.1998;
RA Zhang Y., Cronan J.E. Jr.;
RT "Transcriptional analysis of essential genes of the Escherichia coli fatty
RT acid biosynthesis gene cluster by functional replacement with the analogous
RT Salmonella typhimurium gene cluster.";
RL J. Bacteriol. 180:3295-3303(1998).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=LT2 / SGSC1412 / ATCC 700720;
RX PubMed=11677609; DOI=10.1038/35101614;
RA McClelland M., Sanderson K.E., Spieth J., Clifton S.W., Latreille P.,
RA Courtney L., Porwollik S., Ali J., Dante M., Du F., Hou S., Layman D.,
RA Leonard S., Nguyen C., Scott K., Holmes A., Grewal N., Mulvaney E.,
RA Ryan E., Sun H., Florea L., Miller W., Stoneking T., Nhan M., Waterston R.,
RA Wilson R.K.;
RT "Complete genome sequence of Salmonella enterica serovar Typhimurium LT2.";
RL Nature 413:852-856(2001).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=holo-[ACP] + malonyl-CoA = CoA + malonyl-[ACP];
CC Xref=Rhea:RHEA:41792, Rhea:RHEA-COMP:9623, Rhea:RHEA-COMP:9685,
CC ChEBI:CHEBI:57287, ChEBI:CHEBI:57384, ChEBI:CHEBI:64479,
CC ChEBI:CHEBI:78449; EC=2.3.1.39;
CC -!- PATHWAY: Lipid metabolism; fatty acid biosynthesis.
CC -!- SIMILARITY: Belongs to the FabD family. {ECO:0000305}.
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DR EMBL; AF044668; AAC38649.1; -; Genomic_DNA.
DR EMBL; AE006468; AAL20123.1; -; Genomic_DNA.
DR RefSeq; NP_460164.1; NC_003197.2.
DR RefSeq; WP_000191343.1; NC_003197.2.
DR PDB; 3H0P; X-ray; 2.00 A; A/B=1-309.
DR PDBsum; 3H0P; -.
DR AlphaFoldDB; O85140; -.
DR SMR; O85140; -.
DR STRING; 99287.STM1194; -.
DR PaxDb; O85140; -.
DR EnsemblBacteria; AAL20123; AAL20123; STM1194.
DR GeneID; 1252712; -.
DR KEGG; stm:STM1194; -.
DR PATRIC; fig|99287.12.peg.1263; -.
DR HOGENOM; CLU_030558_0_0_6; -.
DR OMA; AANYNCP; -.
DR PhylomeDB; O85140; -.
DR BioCyc; SENT99287:STM1194-MON; -.
DR UniPathway; UPA00094; -.
DR EvolutionaryTrace; O85140; -.
DR Proteomes; UP000001014; Chromosome.
DR GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR GO; GO:0004314; F:[acyl-carrier-protein] S-malonyltransferase activity; IBA:GO_Central.
DR GO; GO:0006633; P:fatty acid biosynthetic process; IBA:GO_Central.
DR Gene3D; 3.40.366.10; -; 1.
DR InterPro; IPR001227; Ac_transferase_dom_sf.
DR InterPro; IPR014043; Acyl_transferase.
DR InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR InterPro; IPR024925; Malonyl_CoA-ACP_transAc.
DR InterPro; IPR004410; Malonyl_CoA-ACP_transAc_FabD.
DR InterPro; IPR016036; Malonyl_transacylase_ACP-bd.
DR Pfam; PF00698; Acyl_transf_1; 1.
DR PIRSF; PIRSF000446; Mct; 1.
DR SMART; SM00827; PKS_AT; 1.
DR SUPFAM; SSF52151; SSF52151; 1.
DR SUPFAM; SSF55048; SSF55048; 1.
DR TIGRFAMs; TIGR00128; fabD; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Acyltransferase; Fatty acid biosynthesis;
KW Fatty acid metabolism; Lipid biosynthesis; Lipid metabolism;
KW Reference proteome; Transferase.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000250"
FT CHAIN 2..309
FT /note="Malonyl CoA-acyl carrier protein transacylase"
FT /id="PRO_0000194219"
FT ACT_SITE 92
FT /evidence="ECO:0000250"
FT ACT_SITE 201
FT /evidence="ECO:0000250"
FT STRAND 4..8
FT /evidence="ECO:0007829|PDB:3H0P"
FT TURN 16..19
FT /evidence="ECO:0007829|PDB:3H0P"
FT HELIX 20..25
FT /evidence="ECO:0007829|PDB:3H0P"
FT HELIX 28..40
FT /evidence="ECO:0007829|PDB:3H0P"
FT HELIX 44..50
FT /evidence="ECO:0007829|PDB:3H0P"
FT HELIX 53..56
FT /evidence="ECO:0007829|PDB:3H0P"
FT HELIX 59..79
FT /evidence="ECO:0007829|PDB:3H0P"
FT STRAND 88..91
FT /evidence="ECO:0007829|PDB:3H0P"
FT HELIX 93..101
FT /evidence="ECO:0007829|PDB:3H0P"
FT HELIX 107..123
FT /evidence="ECO:0007829|PDB:3H0P"
FT STRAND 129..137
FT /evidence="ECO:0007829|PDB:3H0P"
FT HELIX 140..151
FT /evidence="ECO:0007829|PDB:3H0P"
FT STRAND 156..163
FT /evidence="ECO:0007829|PDB:3H0P"
FT STRAND 166..172
FT /evidence="ECO:0007829|PDB:3H0P"
FT HELIX 173..185
FT /evidence="ECO:0007829|PDB:3H0P"
FT STRAND 189..193
FT /evidence="ECO:0007829|PDB:3H0P"
FT HELIX 203..205
FT /evidence="ECO:0007829|PDB:3H0P"
FT HELIX 206..217
FT /evidence="ECO:0007829|PDB:3H0P"
FT STRAND 228..230
FT /evidence="ECO:0007829|PDB:3H0P"
FT TURN 231..234
FT /evidence="ECO:0007829|PDB:3H0P"
FT HELIX 240..250
FT /evidence="ECO:0007829|PDB:3H0P"
FT HELIX 257..266
FT /evidence="ECO:0007829|PDB:3H0P"
FT STRAND 271..274
FT /evidence="ECO:0007829|PDB:3H0P"
FT STRAND 276..279
FT /evidence="ECO:0007829|PDB:3H0P"
FT HELIX 280..288
FT /evidence="ECO:0007829|PDB:3H0P"
FT STRAND 293..296
FT /evidence="ECO:0007829|PDB:3H0P"
FT HELIX 300..307
FT /evidence="ECO:0007829|PDB:3H0P"
SQ SEQUENCE 309 AA; 32405 MW; 73B4AB6EF02127DE CRC64;
MTQFAFVFPG QGSQSVGMLA EMAANYPIVE ETFAEASAAL GYDLWALTQQ GPAEELNKTW
QTQPALLTAS VALWRVWQQQ GGKMPALMAG HSLGEYSALV CAGVINFADA VRLVEMRGKF
MQEAVPEGTG GMSAIIGLDD ASIAKACEES AEGQVVSPVN FNSPGQVVIA GHKEAVERAG
AACKAAGAKR ALPLPVSVPS HCALMKPAAD KLAVELAKIT FSAPTVPVVN NVDVKCETDA
AAIRDALVRQ LYNPVQWTKS VEFIAAQGVE HLYEVGPGKV LTGLTKRIVD TLTASALNEP
AALSAALTQ
