ID   FABD_STAAU              Reviewed;         308 AA.
AC   Q93QD4; Q5TKS3;
DT   24-JAN-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-2001, sequence version 1.
DT   25-MAY-2022, entry version 97.
DE   RecName: Full=Malonyl CoA-acyl carrier protein transacylase;
DE            Short=MCT;
DE            EC=2.3.1.39;
GN   Name=fabD;
OS   Staphylococcus aureus.
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=1280;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Lin A.H., Choi G.H., McCroskey M., Harris D.W., Murray R.W.,
RA   Rockenbach S.K., Curry K.A., Marotti K.R.;
RT   "Cloning and characterization of S.aureus malonyl-CoA:ACP S-malonyl
RT   transferase.";
RL   Submitted (JUN-2000) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 6-303.
RC   STRAIN=Smith;
RA   Morita Y., Ikeno S., Tsuchiya K.S.;
RT   "Cloning and expression of Staphylococcus aureus Smith fab genes.";
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=holo-[ACP] + malonyl-CoA = CoA + malonyl-[ACP];
CC         Xref=Rhea:RHEA:41792, Rhea:RHEA-COMP:9623, Rhea:RHEA-COMP:9685,
CC         ChEBI:CHEBI:57287, ChEBI:CHEBI:57384, ChEBI:CHEBI:64479,
CC         ChEBI:CHEBI:78449; EC=2.3.1.39;
CC   -!- PATHWAY: Lipid metabolism; fatty acid biosynthesis.
CC   -!- SIMILARITY: Belongs to the FabD family. {ECO:0000305}.
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DR   EMBL; AF275318; AAK69406.1; -; Genomic_DNA.
DR   EMBL; AB195288; BAD72836.1; -; Genomic_DNA.
DR   RefSeq; WP_000047348.1; NZ_WOFG01000001.1.
DR   AlphaFoldDB; Q93QD4; -.
DR   SMR; Q93QD4; -.
DR   ChEMBL; CHEMBL1075258; -.
DR   OMA; AANYNCP; -.
DR   UniPathway; UPA00094; -.
DR   PRO; PR:Q93QD4; -.
DR   GO; GO:0004314; F:[acyl-carrier-protein] S-malonyltransferase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006633; P:fatty acid biosynthetic process; IEA:UniProtKB-UniPathway.
DR   Gene3D; 3.40.366.10; -; 1.
DR   InterPro; IPR001227; Ac_transferase_dom_sf.
DR   InterPro; IPR014043; Acyl_transferase.
DR   InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR   InterPro; IPR024925; Malonyl_CoA-ACP_transAc.
DR   InterPro; IPR004410; Malonyl_CoA-ACP_transAc_FabD.
DR   InterPro; IPR016036; Malonyl_transacylase_ACP-bd.
DR   Pfam; PF00698; Acyl_transf_1; 1.
DR   PIRSF; PIRSF000446; Mct; 1.
DR   SMART; SM00827; PKS_AT; 1.
DR   SUPFAM; SSF52151; SSF52151; 1.
DR   SUPFAM; SSF55048; SSF55048; 1.
DR   TIGRFAMs; TIGR00128; fabD; 1.
PE   3: Inferred from homology;
KW   Acyltransferase; Fatty acid biosynthesis; Fatty acid metabolism;
KW   Lipid biosynthesis; Lipid metabolism; Transferase.
FT   CHAIN           1..308
FT                   /note="Malonyl CoA-acyl carrier protein transacylase"
FT                   /id="PRO_0000194220"
FT   ACT_SITE        89
FT                   /evidence="ECO:0000250"
FT   ACT_SITE        199
FT                   /evidence="ECO:0000250"
FT   CONFLICT        23
FT                   /note="F -> Y (in Ref. 2; BAD72836)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        53
FT                   /note="E -> D (in Ref. 2; BAD72836)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        220
FT                   /note="R -> H (in Ref. 2; BAD72836)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   308 AA;  33635 MW;  C28AEC6CC50805C2 CRC64;
     MSKTAIIFPG QGAQKVGMAQ DLFNNNDQAT EILTSAANTL DFDILETMFT DEEGKLGETE
     NTQPALLTHS SALLAALKNL NPDFTMGHSL GEYSSLVAAD VLSFEDAVKI VRKRGQLMAQ
     AFPTGVGSMA AVLGLDFDKV DEICKSLSSD DKIIEPANIN CPGQIVVSGH KALIDELVEK
     GKSLGAKRVM PLAVSGPFHS SLMKVIEEDF SSYINQFEWR DAKFPVVQNV NAQGETDKEV
     IKSNMVKQLY SPVQFINSTE WLIDQGVDHF IEIGPGKVLS GLIKKINRDV KLTSIQTLED
     VKGWNEND