FABD_SYNY3
ID FABD_SYNY3 Reviewed; 293 AA.
AC P73242;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1997, sequence version 1.
DT 25-MAY-2022, entry version 123.
DE RecName: Full=Malonyl CoA-acyl carrier protein transacylase;
DE Short=MCT;
DE EC=2.3.1.39;
GN Name=fabD; OrderedLocusNames=slr2023;
OS Synechocystis sp. (strain PCC 6803 / Kazusa).
OC Bacteria; Cyanobacteria; Synechococcales; Merismopediaceae; Synechocystis;
OC unclassified Synechocystis.
OX NCBI_TaxID=1111708;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PCC 6803 / Kazusa;
RX PubMed=8905231; DOI=10.1093/dnares/3.3.109;
RA Kaneko T., Sato S., Kotani H., Tanaka A., Asamizu E., Nakamura Y.,
RA Miyajima N., Hirosawa M., Sugiura M., Sasamoto S., Kimura T., Hosouchi T.,
RA Matsuno A., Muraki A., Nakazaki N., Naruo K., Okumura S., Shimpo S.,
RA Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S.;
RT "Sequence analysis of the genome of the unicellular cyanobacterium
RT Synechocystis sp. strain PCC6803. II. Sequence determination of the entire
RT genome and assignment of potential protein-coding regions.";
RL DNA Res. 3:109-136(1996).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=holo-[ACP] + malonyl-CoA = CoA + malonyl-[ACP];
CC Xref=Rhea:RHEA:41792, Rhea:RHEA-COMP:9623, Rhea:RHEA-COMP:9685,
CC ChEBI:CHEBI:57287, ChEBI:CHEBI:57384, ChEBI:CHEBI:64479,
CC ChEBI:CHEBI:78449; EC=2.3.1.39;
CC -!- PATHWAY: Lipid metabolism; fatty acid biosynthesis.
CC -!- SIMILARITY: Belongs to the FabD family. {ECO:0000305}.
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DR EMBL; BA000022; BAA17269.1; -; Genomic_DNA.
DR PIR; S75355; S75355.
DR PDB; 4RR5; X-ray; 2.43 A; A=1-293.
DR PDBsum; 4RR5; -.
DR AlphaFoldDB; P73242; -.
DR SMR; P73242; -.
DR STRING; 1148.1652346; -.
DR PaxDb; P73242; -.
DR EnsemblBacteria; BAA17269; BAA17269; BAA17269.
DR KEGG; syn:slr2023; -.
DR eggNOG; COG0331; Bacteria.
DR InParanoid; P73242; -.
DR OMA; AANYNCP; -.
DR PhylomeDB; P73242; -.
DR BRENDA; 2.3.1.39; 382.
DR UniPathway; UPA00094; -.
DR Proteomes; UP000001425; Chromosome.
DR GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR GO; GO:0004314; F:[acyl-carrier-protein] S-malonyltransferase activity; IBA:GO_Central.
DR GO; GO:0006633; P:fatty acid biosynthetic process; IBA:GO_Central.
DR Gene3D; 3.40.366.10; -; 1.
DR InterPro; IPR001227; Ac_transferase_dom_sf.
DR InterPro; IPR014043; Acyl_transferase.
DR InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR InterPro; IPR024925; Malonyl_CoA-ACP_transAc.
DR InterPro; IPR004410; Malonyl_CoA-ACP_transAc_FabD.
DR InterPro; IPR016036; Malonyl_transacylase_ACP-bd.
DR Pfam; PF00698; Acyl_transf_1; 1.
DR PIRSF; PIRSF000446; Mct; 1.
DR SMART; SM00827; PKS_AT; 1.
DR SUPFAM; SSF52151; SSF52151; 1.
DR SUPFAM; SSF55048; SSF55048; 1.
DR TIGRFAMs; TIGR00128; fabD; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Acyltransferase; Fatty acid biosynthesis;
KW Fatty acid metabolism; Lipid biosynthesis; Lipid metabolism;
KW Reference proteome; Transferase.
FT CHAIN 1..293
FT /note="Malonyl CoA-acyl carrier protein transacylase"
FT /id="PRO_0000194227"
FT ACT_SITE 88
FT /evidence="ECO:0000250"
FT ACT_SITE 188
FT /evidence="ECO:0000250"
FT STRAND 3..7
FT /evidence="ECO:0007829|PDB:4RR5"
FT TURN 15..18
FT /evidence="ECO:0007829|PDB:4RR5"
FT HELIX 19..23
FT /evidence="ECO:0007829|PDB:4RR5"
FT HELIX 25..38
FT /evidence="ECO:0007829|PDB:4RR5"
FT HELIX 42..46
FT /evidence="ECO:0007829|PDB:4RR5"
FT HELIX 50..54
FT /evidence="ECO:0007829|PDB:4RR5"
FT HELIX 56..76
FT /evidence="ECO:0007829|PDB:4RR5"
FT STRAND 82..87
FT /evidence="ECO:0007829|PDB:4RR5"
FT HELIX 90..97
FT /evidence="ECO:0007829|PDB:4RR5"
FT HELIX 103..119
FT /evidence="ECO:0007829|PDB:4RR5"
FT STRAND 124..131
FT /evidence="ECO:0007829|PDB:4RR5"
FT HELIX 133..140
FT /evidence="ECO:0007829|PDB:4RR5"
FT STRAND 144..153
FT /evidence="ECO:0007829|PDB:4RR5"
FT STRAND 156..161
FT /evidence="ECO:0007829|PDB:4RR5"
FT HELIX 163..171
FT /evidence="ECO:0007829|PDB:4RR5"
FT STRAND 173..176
FT /evidence="ECO:0007829|PDB:4RR5"
FT STRAND 178..180
FT /evidence="ECO:0007829|PDB:4RR5"
FT HELIX 190..192
FT /evidence="ECO:0007829|PDB:4RR5"
FT HELIX 193..204
FT /evidence="ECO:0007829|PDB:4RR5"
FT STRAND 215..217
FT /evidence="ECO:0007829|PDB:4RR5"
FT STRAND 220..224
FT /evidence="ECO:0007829|PDB:4RR5"
FT HELIX 227..235
FT /evidence="ECO:0007829|PDB:4RR5"
FT TURN 236..239
FT /evidence="ECO:0007829|PDB:4RR5"
FT HELIX 244..254
FT /evidence="ECO:0007829|PDB:4RR5"
FT STRAND 258..266
FT /evidence="ECO:0007829|PDB:4RR5"
FT HELIX 267..273
FT /evidence="ECO:0007829|PDB:4RR5"
FT STRAND 279..284
FT /evidence="ECO:0007829|PDB:4RR5"
FT HELIX 287..291
FT /evidence="ECO:0007829|PDB:4RR5"
SQ SEQUENCE 293 AA; 31491 MW; 31E4ABA59ECDB377 CRC64;
MKTAWVFPGQ GSQAVGMGVD LLSTAIAKEK YQQAEEILGW SVVEKCQGDE ASLALTQNTQ
PCLYVIEAIL ADLLRDKGFQ PDYVAGHSLG EYSALYAAGV FDFATGLQLV KQRSEVMASA
SGGMMAALMK FDQTQLQQAL TDNTEVVLAN DNSPEQVVIS GTVAGVEAIL ANVKARRAVP
LKVSGAFHSS FMAQPSQSFA QTLTACHFND ATVPVLSNVD PSPTQNGDRL KEKLIQQMTG
SVRWRETMVN LGEIGATDYW EVGPGKVLTG LCKRTCPDLN LKNIGQLDDL NSL
