AHR1_CANAL
ID AHR1_CANAL Reviewed; 624 AA.
AC Q5A4F3; A0A1D8PKK0; Q53EJ0;
DT 28-NOV-2012, integrated into UniProtKB/Swiss-Prot.
DT 26-APR-2005, sequence version 1.
DT 25-MAY-2022, entry version 111.
DE RecName: Full=Adhesion and hyphal regulator 1;
DE AltName: Full=Zinc finger transcription factor 37;
GN Name=AHR1; Synonyms=ZCF37; OrderedLocusNames=CAALFM_C306000WA;
GN ORFNames=CaO19.7381;
OS Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX NCBI_TaxID=237561;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=15123810; DOI=10.1073/pnas.0401648101;
RA Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B.,
RA Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W.,
RA Scherer S.;
RT "The diploid genome sequence of Candida albicans.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=17419877; DOI=10.1186/gb-2007-8-4-r52;
RA van het Hoog M., Rast T.J., Martchenko M., Grindle S., Dignard D.,
RA Hogues H., Cuomo C., Berriman M., Scherer S., Magee B.B., Whiteway M.,
RA Chibana H., Nantel A., Magee P.T.;
RT "Assembly of the Candida albicans genome into sixteen supercontigs aligned
RT on the eight chromosomes.";
RL Genome Biol. 8:RESEARCH52.1-RESEARCH52.12(2007).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=24025428; DOI=10.1186/gb-2013-14-9-r97;
RA Muzzey D., Schwartz K., Weissman J.S., Sherlock G.;
RT "Assembly of a phased diploid Candida albicans genome facilitates allele-
RT specific measurements and provides a simple model for repeat and indel
RT structure.";
RL Genome Biol. 14:RESEARCH97.1-RESEARCH97.14(2013).
RN [4]
RP DOMAIN, AND POSSIBLE FUNCTION.
RX PubMed=18629206; DOI=10.1002/cfg.492;
RA Maicas S., Moreno I., Nieto A., Gomez M., Sentandreu R., Valentin E.;
RT "In silico analysis for transcription factors with Zn(II)(2)C(6) binuclear
RT cluster DNA-binding domains in Candida albicans.";
RL Comp. Funct. Genomics 6:345-356(2005).
RN [5]
RP FUNCTION.
RX PubMed=16939537; DOI=10.1111/j.1462-5822.2006.00784.x;
RA Chiang L.Y., Sheppard D.C., Bruno V.M., Mitchell A.P., Edwards J.E. Jr.,
RA Filler S.G.;
RT "Candida albicans protein kinase CK2 governs virulence during oropharyngeal
RT candidiasis.";
RL Cell. Microbiol. 9:233-245(2007).
RN [6]
RP FUNCTION, AND DISRUPTION PHENOTYPE.
RX PubMed=21315072; DOI=10.1016/j.febslet.2011.02.005;
RA Wang H., Song W., Huang G., Zhou Z., Ding Y., Chen J.;
RT "Candida albicans Zcf37, a zinc finger protein, is required for
RT stabilization of the white state.";
RL FEBS Lett. 585:797-802(2011).
RN [7]
RP FUNCTION, DNA-BINDING, AND INTERACTION WITH MCM1.
RX PubMed=21299649; DOI=10.1111/j.1365-2958.2010.07504.x;
RA Askew C., Sellam A., Epp E., Mallick J., Hogues H., Mullick A., Nantel A.,
RA Whiteway M.;
RT "The zinc cluster transcription factor Ahr1p directs Mcm1p regulation of
RT Candida albicans adhesion.";
RL Mol. Microbiol. 79:940-953(2011).
RN [8]
RP FUNCTION.
RX PubMed=22073120; DOI=10.1371/journal.pone.0026962;
RA Vandeputte P., Ischer F., Sanglard D., Coste A.T.;
RT "In vivo systematic analysis of Candida albicans Zn2-Cys6 transcription
RT factors mutants for mice organ colonization.";
RL PLoS ONE 6:E26962-E26962(2011).
CC -!- FUNCTION: Transcription factor that binds the promoters of genes
CC involved in biofilm formation, which include several key adhesion
CC genes, and recruits MCM1 to these sites. Plays an important role in
CC hyphal growth and virulence. Promotes conversion of opaque cells to
CC white phase, but needs existence of EFG1, a key regulator required for
CC maintenance of the white state. {ECO:0000269|PubMed:16939537,
CC ECO:0000269|PubMed:21299649, ECO:0000269|PubMed:21315072,
CC ECO:0000269|PubMed:22073120}.
CC -!- SUBUNIT: Interacts with MCM1. {ECO:0000269|PubMed:21299649}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00227}.
CC -!- DISRUPTION PHENOTYPE: Stabilizes the opaque phase.
CC {ECO:0000269|PubMed:21315072}.
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DR EMBL; CP017625; AOW28608.1; -; Genomic_DNA.
DR RefSeq; XP_716622.1; XM_711529.1.
DR AlphaFoldDB; Q5A4F3; -.
DR BioGRID; 1224827; 2.
DR STRING; 237561.Q5A4F3; -.
DR GeneID; 3641733; -.
DR KEGG; cal:CAALFM_C306000WA; -.
DR CGD; CAL0000197462; AHR1.
DR VEuPathDB; FungiDB:C3_06000W_A; -.
DR eggNOG; ENOG502QT0Z; Eukaryota.
DR HOGENOM; CLU_410587_0_0_1; -.
DR InParanoid; Q5A4F3; -.
DR OMA; CYRGIRL; -.
DR OrthoDB; 1003010at2759; -.
DR Proteomes; UP000000559; Chromosome 3.
DR GO; GO:0005634; C:nucleus; IGI:CGD.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IMP:CGD.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR GO; GO:0043565; F:sequence-specific DNA binding; IDA:CGD.
DR GO; GO:0000976; F:transcription cis-regulatory region binding; IBA:GO_Central.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0007155; P:cell adhesion; IMP:CGD.
DR GO; GO:0043709; P:cell adhesion involved in single-species biofilm formation; IMP:CGD.
DR GO; GO:0042149; P:cellular response to glucose starvation; IMP:CGD.
DR GO; GO:0030447; P:filamentous growth; IMP:CGD.
DR GO; GO:0036180; P:filamentous growth of a population of unicellular organisms in response to biotic stimulus; IMP:CGD.
DR GO; GO:0001403; P:invasive growth in response to glucose limitation; IGI:CGD.
DR GO; GO:2000134; P:negative regulation of G1/S transition of mitotic cell cycle; IMP:CGD.
DR GO; GO:1900189; P:positive regulation of cell adhesion involved in single-species biofilm formation; IMP:CGD.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IGI:CGD.
DR GO; GO:1900443; P:regulation of filamentous growth of a population of unicellular organisms in response to biotic stimulus; IMP:CGD.
DR GO; GO:1900239; P:regulation of phenotypic switching; IMP:CGD.
DR CDD; cd00067; GAL4; 1.
DR Gene3D; 4.10.240.10; -; 1.
DR InterPro; IPR001138; Zn2-C6_fun-type_DNA-bd.
DR InterPro; IPR036864; Zn2-C6_fun-type_DNA-bd_sf.
DR Pfam; PF00172; Zn_clus; 1.
DR SMART; SM00066; GAL4; 1.
DR SUPFAM; SSF57701; SSF57701; 1.
DR PROSITE; PS00463; ZN2_CY6_FUNGAL_1; 1.
DR PROSITE; PS50048; ZN2_CY6_FUNGAL_2; 1.
PE 1: Evidence at protein level;
KW Cell adhesion; DNA-binding; Metal-binding; Nucleus; Reference proteome;
KW Transcription; Transcription regulation; Virulence; Zinc.
FT CHAIN 1..624
FT /note="Adhesion and hyphal regulator 1"
FT /id="PRO_0000420186"
FT DNA_BIND 19..46
FT /note="Zn(2)-C6 fungal-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00227"
FT REGION 63..84
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 230..250
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 231..250
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 624 AA; 72353 MW; 2A8B55BDAC7A415C CRC64;
MAKKKLNSTI KRSRTRSGCV TCRDRHIKCD EQQPVCKNCQ KSNRKCYRGI RLNFTQYTFY
NPDDNKPKEL QQNEQPNSSH YAFPNLEPNP VSQKHRILDQ SITIASLYDD LKKYKPYIHL
HTPEDLRESD LQFQEDTYNS YISTSAINLR GKKLTKRDPG LSTSLSVINP TLESEIKPNP
VILNQLSFHP PPNLNTGVLY PPTATAATTT TSSPTNHHLH PYFVSSIPNP QHHPMLDTSQ
HQETTSTDPN QFDYSHLSMP QSTPLLMKYD ITTYVRLIET EKYYMLLDLA NELDIWKKII
PSLCLQISEN DSFLLDCLMS CSRNTSVNLL DLTNEQLNKW SQLKNAPVIS ERIQQFEHIL
ISIVLILLGL YLNTTKVRLT DYHKVIFNNQ AKLFSHVLRK IHTFITSNKP NSAVLTNAIQ
SITMLKFFID KNYDFSYEFK NIQKGRVTDT SEEITYSNSN LYSNPDISYI STFNEYEIIY
LNNSYQNLVH VDQSNSMSMG ESQLYKDLLW YLMKVDFVIN YPEAANNLVL DHNVVYQQIT
NASTDLSFSN NLNYLNPRSY ANYFLKEFII KVLSMGSNAI IEDANNRINT LFNFIDQSYM
DPELKSQFHH CFTWTVRYIH PVSD
