FABH2_CUPWR
ID FABH2_CUPWR Reviewed; 402 AA.
AC P49245;
DT 01-FEB-1996, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1996, sequence version 1.
DT 25-MAY-2022, entry version 95.
DE RecName: Full=3-oxoacyl-[acyl-carrier-protein] synthase 3 B, chloroplastic;
DE EC=2.3.1.180;
DE AltName: Full=3-oxoacyl-[acyl-carrier-protein] synthase III B;
DE AltName: Full=Beta-ketoacyl-ACP synthase III B;
DE Short=KAS III B;
DE Flags: Precursor;
GN Name=KAS3B;
OS Cuphea wrightii (Wright's waxweed).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Myrtales; Lythraceae; Cuphea.
OX NCBI_TaxID=35942;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Embryo;
RX PubMed=7784524; DOI=10.1104/pp.108.1.443;
RA Slabaugh M.B., Tai H., Jaworski J., Knapp S.J.;
RT "cDNA clones encoding beta-ketoacyl-acyl carrier protein synthase III from
RT Cuphea wrightii.";
RL Plant Physiol. 108:443-444(1995).
CC -!- FUNCTION: Catalyzes the condensation reaction of fatty acid synthesis
CC by the addition to an acyl acceptor of two carbons from malonyl-ACP.
CC KAS III catalyzes the first condensation reaction which initiates fatty
CC acid synthesis and may therefore play a role in governing the total
CC rate of fatty acid production. Possesses both acetoacetyl-ACP synthase
CC and acetyl transacylase activities (By similarity). {ECO:0000250}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=acetyl-CoA + H(+) + malonyl-[ACP] = 3-oxobutanoyl-[ACP] + CO2
CC + CoA; Xref=Rhea:RHEA:12080, Rhea:RHEA-COMP:9623, Rhea:RHEA-
CC COMP:9625, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:57287,
CC ChEBI:CHEBI:57288, ChEBI:CHEBI:78449, ChEBI:CHEBI:78450;
CC EC=2.3.1.180;
CC -!- PATHWAY: Lipid metabolism; fatty acid biosynthesis.
CC -!- SUBCELLULAR LOCATION: Plastid, chloroplast.
CC -!- SIMILARITY: Belongs to the thiolase-like superfamily. FabH family.
CC {ECO:0000305}.
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DR EMBL; U15934; AAA97534.1; -; mRNA.
DR AlphaFoldDB; P49245; -.
DR SMR; P49245; -.
DR PRIDE; P49245; -.
DR BRENDA; 2.3.1.180; 1755.
DR UniPathway; UPA00094; -.
DR GO; GO:0009507; C:chloroplast; IEA:UniProtKB-SubCell.
DR GO; GO:0004315; F:3-oxoacyl-[acyl-carrier-protein] synthase activity; IEA:InterPro.
DR GO; GO:0033818; F:beta-ketoacyl-acyl-carrier-protein synthase III activity; IEA:UniProtKB-EC.
DR GO; GO:0006633; P:fatty acid biosynthetic process; IEA:UniProtKB-UniPathway.
DR Gene3D; 3.40.47.10; -; 1.
DR HAMAP; MF_01815; FabH; 1.
DR InterPro; IPR013751; ACP_syn_III.
DR InterPro; IPR013747; ACP_syn_III_C.
DR InterPro; IPR004655; FabH_synth.
DR InterPro; IPR016039; Thiolase-like.
DR Pfam; PF08545; ACP_syn_III; 1.
DR Pfam; PF08541; ACP_syn_III_C; 1.
DR SUPFAM; SSF53901; SSF53901; 1.
DR TIGRFAMs; TIGR00747; fabH; 1.
PE 2: Evidence at transcript level;
KW Chloroplast; Fatty acid biosynthesis; Fatty acid metabolism;
KW Lipid biosynthesis; Lipid metabolism; Plastid; Transferase;
KW Transit peptide.
FT TRANSIT 1..?
FT /note="Chloroplast"
FT /evidence="ECO:0000255"
FT CHAIN ?..402
FT /note="3-oxoacyl-[acyl-carrier-protein] synthase 3 B,
FT chloroplastic"
FT /id="PRO_0000008734"
FT ACT_SITE 178
FT /evidence="ECO:0000250"
FT ACT_SITE 328
FT /evidence="ECO:0000250"
FT ACT_SITE 358
FT /evidence="ECO:0000250"
SQ SEQUENCE 402 AA; 42458 MW; 6A6FB1234069EC74 CRC64;
MANAYGFVGH SVPTMKRAAQ FQQMGSGFCS ADSISKRVFC CSVVQGADKP ASGDSRTEYR
TPRLVSRGCK LVGSGSAMPA LQVSNDDLSK IVDTNDEWIS VRTGIRNRRV LTGKESLTNL
ATVAARKALE MAQVDANDVD MVLMCTSTPE DLFGSAPQIQ KALGCKKNPL AYDITAACSG
FVLGLVSAAC HIRGGGFNNI LVIGADSLSR YVDWTDRGTC ILFGDAAGAV LVQSCDAEED
GLFAFDLHSD GDGQRHLKAA ITENGIDHAV GSNGSVSDFP PRSSSYSCIQ MNGKEVFRFA
CRCVPQSIES ALGKAGLNGS NIDWLLLHQA NQRIIDAVAT RLEVPQERVI SNLANYGNTS
AASIPLALDE AVRGGKVKAG HLIATAGFGA GLTWGSAIVR WG
