ID   AHSA_DICDI              Reviewed;         383 AA.
AC   Q55DB6;
DT   29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   24-MAY-2005, sequence version 1.
DT   25-MAY-2022, entry version 87.
DE   RecName: Full=Activator of 90 kDa heat shock protein ATPase homolog;
GN   Name=ahsa; Synonyms=aha1; ORFNames=DDB_G0269712;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- FUNCTION: Co-chaperone that stimulates hspD/HSP90 ATPase activity.
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with hspD/HSP90. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the AHA1 family. {ECO:0000305}.
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DR   EMBL; AAFI02000005; EAL72206.1; -; Genomic_DNA.
DR   RefSeq; XP_646215.1; XM_641123.1.
DR   AlphaFoldDB; Q55DB6; -.
DR   SMR; Q55DB6; -.
DR   STRING; 44689.DDB0266643; -.
DR   PaxDb; Q55DB6; -.
DR   PRIDE; Q55DB6; -.
DR   EnsemblProtists; EAL72206; EAL72206; DDB_G0269712.
DR   GeneID; 8617169; -.
DR   KEGG; ddi:DDB_G0269712; -.
DR   dictyBase; DDB_G0269712; ahsa.
DR   eggNOG; KOG2936; Eukaryota.
DR   HOGENOM; CLU_049046_2_0_1; -.
DR   InParanoid; Q55DB6; -.
DR   OMA; WAIKLAW; -.
DR   PhylomeDB; Q55DB6; -.
DR   PRO; PR:Q55DB6; -.
DR   Proteomes; UP000002195; Chromosome 1.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:0001671; F:ATPase activator activity; IBA:GO_Central.
DR   GO; GO:0051087; F:chaperone binding; IEA:InterPro.
DR   GO; GO:0051879; F:Hsp90 protein binding; IEA:InterPro.
DR   GO; GO:0032781; P:positive regulation of ATP-dependent activity; IBA:GO_Central.
DR   GO; GO:0006457; P:protein folding; IBA:GO_Central.
DR   Gene3D; 3.15.10.20; -; 1.
DR   Gene3D; 3.30.530.20; -; 1.
DR   InterPro; IPR013538; Activator_of_Hsp90_ATPase.
DR   InterPro; IPR036338; Aha1.
DR   InterPro; IPR039981; AHSA-like.
DR   InterPro; IPR015310; AHSA1_N.
DR   InterPro; IPR023393; START-like_dom_sf.
DR   PANTHER; PTHR13009; PTHR13009; 1.
DR   Pfam; PF09229; Aha1_N; 1.
DR   Pfam; PF08327; AHSA1; 1.
DR   SMART; SM01000; Aha1_N; 1.
DR   SUPFAM; SSF103111; SSF103111; 1.
PE   2: Evidence at transcript level;
KW   Chaperone; Cytoplasm; Reference proteome.
FT   CHAIN           1..383
FT                   /note="Activator of 90 kDa heat shock protein ATPase
FT                   homolog"
FT                   /id="PRO_0000330914"
FT   REGION          97..126
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          209..228
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   383 AA;  43082 MW;  91EF03BD79B7F787 CRC64;
     MAKVGEGDPR WIVENREDGH NVNGWHWSEK DCLPWSKNTI GGLFDKKVIQ ETDEYTFKIS
     STPVVSGECT ANNRKGKTIF LYELDVKMNW EVVFKPKKVL PPPPTTKSKG AADDIDEEDD
     DGKPAEPIIT QKKTISGEFT VPYISDENGD EAPTVRYTIN TTADNDETKQ SINMVQSLLK
     SHGVPFVQSQ CQEFIKLLKK EFVSKKQVEQ SQQQQTANTT TNTTTTTNTV PKVTSSTVIF
     NSTPTKKPTT KTLKLKEEFQ CSPMDAYDVF VNINKLRAFT QSDCTFENEE GGKFSLYGGS
     IQGVNKTLSP GSKIVQTWRL DNWSKGVESQ VTITFSVDGK PLTNVEIVQT GIPIDEFEKT
     EEGWKRNILD RIKHTFSYSS KIF