ID   AHYI_AERHY              Reviewed;         207 AA.
AC   Q44058;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1999, sequence version 2.
DT   25-MAY-2022, entry version 76.
DE   RecName: Full=Acyl-homoserine-lactone synthase;
DE            EC=2.3.1.184;
DE   AltName: Full=Autoinducer synthesis protein AhyI;
GN   Name=ahyI;
OS   Aeromonas hydrophila.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Aeromonadales;
OC   Aeromonadaceae; Aeromonas.
OX   NCBI_TaxID=644;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=A1;
RX   PubMed=9286976; DOI=10.1128/jb.179.17.5271-5281.1997;
RA   Swift S., Karlyshev A.V., Fish L., Durant E.L., Winson M.K., Chhabra S.R.,
RA   Williams P., Macintyre S., Stewart G.S.A.B.;
RT   "Quorum sensing in Aeromonas hydrophila and Aeromonas salmonicida:
RT   identification of the LuxRI homologs AhyRI and AsaRI and their cognate N-
RT   acylhomoserine lactone signal molecules.";
RL   J. Bacteriol. 179:5271-5281(1997).
CC   -!- FUNCTION: Required for the synthesis of N-butanoyl-L-homoserine lactone
CC       (BHL), an autoinducer molecule which binds to AhyR.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a fatty acyl-[ACP] + S-adenosyl-L-methionine = an N-acyl-L-
CC         homoserine lactone + H(+) + holo-[ACP] + S-methyl-5'-thioadenosine;
CC         Xref=Rhea:RHEA:10096, Rhea:RHEA-COMP:9685, Rhea:RHEA-COMP:14125,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:17509, ChEBI:CHEBI:55474,
CC         ChEBI:CHEBI:59789, ChEBI:CHEBI:64479, ChEBI:CHEBI:138651;
CC         EC=2.3.1.184;
CC   -!- SIMILARITY: Belongs to the autoinducer synthase family.
CC       {ECO:0000255|PROSITE-ProRule:PRU00533}.
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DR   EMBL; X89469; CAA61653.1; -; Genomic_DNA.
DR   RefSeq; WP_043125540.1; NZ_NKWV01000022.1.
DR   AlphaFoldDB; Q44058; -.
DR   SMR; Q44058; -.
DR   STRING; 1448139.AI20_16595; -.
DR   eggNOG; COG3916; Bacteria.
DR   BRENDA; 2.3.1.184; 164.
DR   GO; GO:0061579; F:N-acyl homoserine lactone synthase activity; IEA:UniProtKB-EC.
DR   GO; GO:0009372; P:quorum sensing; IEA:UniProtKB-KW.
DR   InterPro; IPR016181; Acyl_CoA_acyltransferase.
DR   InterPro; IPR018311; Autoind_synth_CS.
DR   InterPro; IPR001690; Autoind_synthase.
DR   PANTHER; PTHR39322; PTHR39322; 1.
DR   Pfam; PF00765; Autoind_synth; 1.
DR   PRINTS; PR01549; AUTOINDCRSYN.
DR   SUPFAM; SSF55729; SSF55729; 1.
DR   PROSITE; PS00949; AUTOINDUCER_SYNTH_1; 1.
DR   PROSITE; PS51187; AUTOINDUCER_SYNTH_2; 1.
PE   3: Inferred from homology;
KW   Autoinducer synthesis; Quorum sensing; S-adenosyl-L-methionine;
KW   Transferase.
FT   CHAIN           1..207
FT                   /note="Acyl-homoserine-lactone synthase"
FT                   /id="PRO_0000210879"
SQ   SEQUENCE   207 AA;  23613 MW;  F07C0DBA8201B7F2 CRC64;
     MLVFKGKLKE HPRWEVENEL YRFRNRVFSD RLGWDVESHR GLEQDSFDTP DTHWVLIEDE
     EGLCGCIRLL SCAKDYMLPS IFPTALAGEA PPRSNDVWEL TRLAIDAERA PRLGNGISEL
     TCIIFREVYA FAKAQGIREL VAVVSLPVER IFRRLGLPIE RLGHRQAVDL GAVRGVGIRF
     HLDERFARAV GQPLQGAYDE ARELVTE