ID   AHYR_AERHY              Reviewed;         260 AA.
AC   P0A3J5; Q44059;
DT   15-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT   15-MAR-2005, sequence version 1.
DT   25-MAY-2022, entry version 69.
DE   RecName: Full=Transcriptional activator protein AhyR {ECO:0000305};
GN   Name=ahyR {ECO:0000303|PubMed:9286976};
OS   Aeromonas hydrophila.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Aeromonadales;
OC   Aeromonadaceae; Aeromonas.
OX   NCBI_TaxID=644;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=A1;
RX   PubMed=9286976; DOI=10.1128/jb.179.17.5271-5281.1997;
RA   Swift S., Karlyshev A.V., Fish L., Durant E.L., Winson M.K., Chhabra S.R.,
RA   Williams P., Macintyre S., Stewart G.S.A.B.;
RT   "Quorum sensing in Aeromonas hydrophila and Aeromonas salmonicida:
RT   identification of the LuxRI homologs AhyRI and AsaRI and their cognate N-
RT   acylhomoserine lactone signal molecules.";
RL   J. Bacteriol. 179:5271-5281(1997).
CC   -!- FUNCTION: Functions as a BHL-responsive transcriptional regulator.
CC   -!- SIMILARITY: Belongs to the autoinducer-regulated transcriptional
CC       regulatory protein family. {ECO:0000305}.
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DR   EMBL; X89469; CAA61654.1; -; Genomic_DNA.
DR   PIR; S57939; S57939.
DR   RefSeq; WP_005315931.1; NZ_RQKC01000129.1.
DR   AlphaFoldDB; P0A3J5; -.
DR   SMR; P0A3J5; -.
DR   STRING; 1448139.AI20_16590; -.
DR   GeneID; 60850963; -.
DR   GeneID; 64357006; -.
DR   eggNOG; COG2771; Bacteria.
DR   OrthoDB; 1687028at2; -.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0009372; P:quorum sensing; IEA:UniProtKB-KW.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR   CDD; cd06170; LuxR_C_like; 1.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 3.30.450.80; -; 1.
DR   InterPro; IPR016032; Sig_transdc_resp-reg_C-effctor.
DR   InterPro; IPR005143; TF_LuxR_autoind-bd_dom.
DR   InterPro; IPR036693; TF_LuxR_autoind-bd_dom_sf.
DR   InterPro; IPR000792; Tscrpt_reg_LuxR_C.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   Pfam; PF03472; Autoind_bind; 1.
DR   Pfam; PF00196; GerE; 1.
DR   PRINTS; PR00038; HTHLUXR.
DR   SMART; SM00421; HTH_LUXR; 1.
DR   SUPFAM; SSF46894; SSF46894; 1.
DR   SUPFAM; SSF75516; SSF75516; 1.
DR   PROSITE; PS50043; HTH_LUXR_2; 1.
PE   3: Inferred from homology;
KW   Activator; DNA-binding; Quorum sensing; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..260
FT                   /note="Transcriptional activator protein AhyR"
FT                   /id="PRO_0000184137"
FT   DOMAIN          176..241
FT                   /note="HTH luxR-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00411"
FT   DNA_BIND        200..219
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00411"
SQ   SEQUENCE   260 AA;  29350 MW;  65C442032DE1C2CC CRC64;
     MKQDQLLEYL EHFTSVTDGD RLAELIGRFT LGMGYDYYRF ALIIPMSMQR PKVVLFNQCP
     DSWVQAYTAN HMLACDPIIQ LARKQTLPIY WNRLDERARF LQEGSLDVMG LAAEFGLRNG
     ISFPLHGAAG ENGILSFITA ERASSDLLLE SSPILSWMSN YIFEAAIRIV RVSLREDDPQ
     EALTDRETEC LFWASEGKTS GEIACILGIT ERTVNYHLNQ VTRKTGSMNR YQAIAKGVSS
     GILLPNLEQV VVTNFPKLMQ