AI1M_YEAST
ID AI1M_YEAST Reviewed; 834 AA.
AC P03875; A0A0A7NYG1; Q9ZZX5;
DT 21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT 20-DEC-2005, sequence version 2.
DT 03-AUG-2022, entry version 165.
DE RecName: Full=Putative COX1/OXI3 intron 1 protein;
GN Name=AI1; OrderedLocusNames=Q0050;
OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OG Mitochondrion.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=559292;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 24657 / D273-10B;
RX PubMed=6254986; DOI=10.1016/s0021-9258(19)70224-5;
RA Bonitz S.G., Coruzzi G., Thalenfeld B.E., Tzagoloff A., Macino G.;
RT "Assembly of the mitochondrial membrane system. Structure and nucleotide
RT sequence of the gene coding for subunit 1 of yeast cytochrome oxidase.";
RL J. Biol. Chem. 255:11927-11941(1980).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=3549452; DOI=10.1016/0378-1119(86)90060-0;
RA de Zamaroczy M., Bernardi G.;
RT "The primary structure of the mitochondrial genome of Saccharomyces
RT cerevisiae -- a review.";
RL Gene 47:155-177(1986).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 96604 / S288c / FY1679;
RX PubMed=9872396; DOI=10.1016/s0014-5793(98)01467-7;
RA Foury F., Roganti T., Lecrenier N., Purnelle B.;
RT "The complete sequence of the mitochondrial genome of Saccharomyces
RT cerevisiae.";
RL FEBS Lett. 440:325-331(1998).
RN [4]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 96604 / S288c / FY1679;
RX PubMed=24374639; DOI=10.1534/g3.113.008995;
RA Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL G3 (Bethesda) 4:389-398(2014).
CC -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000305}.
CC -!- MISCELLANEOUS: This protein is coded in group-II intron 1 of OXI3
CC (COX1).
CC -!- SEQUENCE CAUTION:
CC Sequence=CAA24071.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; V00694; CAA24071.1; ALT_INIT; Genomic_DNA.
DR EMBL; L36897; AAA67532.1; -; Genomic_DNA.
DR EMBL; KP263414; AIZ98886.1; -; Genomic_DNA.
DR PIR; A04508; QXBY31.
DR PIR; S78642; S78642.
DR RefSeq; NP_009310.1; NC_001224.1.
DR AlphaFoldDB; P03875; -.
DR BioGRID; 34785; 7.
DR DIP; DIP-8242N; -.
DR IntAct; P03875; 1.
DR MINT; P03875; -.
DR STRING; 4932.Q0050; -.
DR REBASE; 2622; I-SceIII.
DR REBASE; 2956; I-SceVI.
DR MaxQB; P03875; -.
DR PaxDb; P03875; -.
DR PRIDE; P03875; -.
DR EnsemblFungi; Q0050_mRNA; Q0050; Q0050.
DR GeneID; 854593; -.
DR KEGG; sce:Q0050; -.
DR SGD; S000007261; AI1.
DR VEuPathDB; FungiDB:Q0050; -.
DR eggNOG; KOG4768; Eukaryota.
DR GeneTree; ENSGT00730000113263; -.
DR HOGENOM; CLU_013584_3_1_1; -.
DR InParanoid; P03875; -.
DR OMA; VFIRITI; -.
DR BioCyc; YEAST:G3O-34372-MON; -.
DR PRO; PR:P03875; -.
DR Proteomes; UP000002311; Mitochondrion.
DR RNAct; P03875; protein.
DR GO; GO:0005739; C:mitochondrion; IMP:SGD.
DR GO; GO:0003964; F:RNA-directed DNA polymerase activity; IMP:SGD.
DR GO; GO:0006315; P:homing of group II introns; IDA:SGD.
DR GO; GO:0090615; P:mitochondrial mRNA processing; IBA:GO_Central.
DR GO; GO:0006397; P:mRNA processing; IDA:SGD.
DR GO; GO:0006278; P:RNA-templated DNA biosynthetic process; IMP:SGD.
DR CDD; cd00085; HNHc; 1.
DR Gene3D; 1.20.210.10; -; 1.
DR InterPro; IPR036927; Cyt_c_oxase-like_su1_sf.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR024937; Domain_X.
DR InterPro; IPR003615; HNH_nuc.
DR InterPro; IPR000477; RT_dom.
DR Pfam; PF01348; Intron_maturas2; 1.
DR Pfam; PF00078; RVT_1; 1.
DR SMART; SM00507; HNHc; 1.
DR SUPFAM; SSF56672; SSF56672; 1.
DR SUPFAM; SSF81442; SSF81442; 1.
DR PROSITE; PS50878; RT_POL; 1.
PE 4: Predicted;
KW Mitochondrion; Reference proteome.
FT CHAIN 1..834
FT /note="Putative COX1/OXI3 intron 1 protein"
FT /id="PRO_0000196880"
FT DOMAIN 296..577
FT /note="Reverse transcriptase"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00405"
FT REGION 162..188
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 162..181
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 118
FT /note="F -> N (in Ref. 1 and 2)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 834 AA; 96079 MW; BFB64B6F36416A5A CRC64;
MVQRWLYSTN AKDIAVLYFM LAIFSGMAGT AMSLIIRLEL AAPGSQYLHG NSQLFNGAPT
SAYISLMRTA LVLWIINRYL KHMTNSVGAN FTGTMACHKT PMISVGGVKC YMVRLTNFLQ
VFIRITISSY HLDMVKQVWL FYVEVIRLWF IVLDSTGSVK KMKDTNNTKG NTKSEGSTER
GNSGVDRGMV VPNTQMKMRF LNQVRYYSVN NNLKMGKDTN IELSKDTSTS DLLEFEKLVM
DNMNEENMNN NLLSIMKNVD MLMLAYNRIK SKPGNMTPGT TLETLDGMNM MYLNKLSNEL
GTGKFKFKPM RMVNIPKPKG GMRPLSVGNP RDKIVQEVMR MILDTIFDKK MSTHSHGFRK
NMSCQTAIWE VRNMFGGSNW FIEVDLKKCF DTISHDLIIK ELKRYISDKG FIDLVYKLLR
AGYIDEKGTY HKPMLGLPQG SLISPILCNI VMTLVDNWLE DYINLYNKGK VKKQHPTYKK
LSRMIAKAKM FSTRLKLHKE RAKGPTFIYN DPNFKRMKYV RYADDILIGV LGSKNDCKMI
KRDLNNFLNS LGLTMNEEKT LITCATETPA RFLGYNISIT PLKRMPTVTK TIRGKTIRSR
NTTRPIINAP IRDIINKLAT NGYCKHNKNG RMGVPTRVGR WTYEEPRTII NNYKALGRGI
LNYYKLATNY KRLRERIYYV LYYSCVLTLA SKYRLKTMSK TIKKFGYNLN IIENDKLIAN
FPRNTFDNIK KIENHGMFMY MSEAKVTDPF EYIDSIKYML PTAKANFNKP CSICNSTIDV
EMHHVKQLHR GMLKATKDYI TGRMITMNRK QIPLCKQCHI KTHKNKFKNM GPGM
