ID   AI2M_YEAST              Reviewed;         854 AA.
AC   P03876; A0A0A7NYJ2; Q9ZZX4;
DT   21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT   20-DEC-2005, sequence version 2.
DT   03-AUG-2022, entry version 155.
DE   RecName: Full=Putative COX1/OXI3 intron 2 protein;
GN   Name=AI2; OrderedLocusNames=Q0055;
OS   Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OG   Mitochondrion.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX   NCBI_TaxID=559292;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 24657 / D273-10B;
RX   PubMed=6254986; DOI=10.1016/s0021-9258(19)70224-5;
RA   Bonitz S.G., Coruzzi G., Thalenfeld B.E., Tzagoloff A., Macino G.;
RT   "Assembly of the mitochondrial membrane system. Structure and nucleotide
RT   sequence of the gene coding for subunit 1 of yeast cytochrome oxidase.";
RL   J. Biol. Chem. 255:11927-11941(1980).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 96604 / S288c / FY1679;
RX   PubMed=9872396; DOI=10.1016/s0014-5793(98)01467-7;
RA   Foury F., Roganti T., Lecrenier N., Purnelle B.;
RT   "The complete sequence of the mitochondrial genome of Saccharomyces
RT   cerevisiae.";
RL   FEBS Lett. 440:325-331(1998).
RN   [3]
RP   GENOME REANNOTATION.
RC   STRAIN=ATCC 96604 / S288c / FY1679;
RX   PubMed=24374639; DOI=10.1534/g3.113.008995;
RA   Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA   Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA   Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT   "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL   G3 (Bethesda) 4:389-398(2014).
CC   -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000305}.
CC   -!- MISCELLANEOUS: This protein is coded in group-II intron 2 of OXI3
CC       (COX1).
CC   -!- SEQUENCE CAUTION:
CC       Sequence=CAA24060.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR   EMBL; V00694; CAA24060.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; KP263414; AIZ98885.1; -; Genomic_DNA.
DR   PIR; A04509; QXBY32.
DR   PIR; S78644; S78644.
DR   RefSeq; NP_009309.1; NC_001224.1.
DR   AlphaFoldDB; P03876; -.
DR   SMR; P03876; -.
DR   BioGRID; 34786; 3.
DR   STRING; 4932.Q0055; -.
DR   iPTMnet; P03876; -.
DR   MaxQB; P03876; -.
DR   PaxDb; P03876; -.
DR   PRIDE; P03876; -.
DR   EnsemblFungi; Q0055_mRNA; Q0055; Q0055.
DR   GeneID; 854594; -.
DR   KEGG; sce:Q0055; -.
DR   SGD; S000007262; AI2.
DR   VEuPathDB; FungiDB:Q0055; -.
DR   eggNOG; KOG4768; Eukaryota.
DR   GeneTree; ENSGT00730000113263; -.
DR   HOGENOM; CLU_013584_3_1_1; -.
DR   InParanoid; P03876; -.
DR   BioCyc; YEAST:G3O-34373-MON; -.
DR   PRO; PR:P03876; -.
DR   Proteomes; UP000002311; Mitochondrion.
DR   RNAct; P03876; protein.
DR   GO; GO:0016021; C:integral component of membrane; IEA:InterPro.
DR   GO; GO:0005739; C:mitochondrion; IDA:SGD.
DR   GO; GO:0004129; F:cytochrome-c oxidase activity; IEA:InterPro.
DR   GO; GO:0020037; F:heme binding; IEA:InterPro.
DR   GO; GO:0003964; F:RNA-directed DNA polymerase activity; IDA:SGD.
DR   GO; GO:0009060; P:aerobic respiration; IEA:InterPro.
DR   GO; GO:0006315; P:homing of group II introns; IBA:GO_Central.
DR   GO; GO:0006314; P:intron homing; IMP:SGD.
DR   GO; GO:0090615; P:mitochondrial mRNA processing; IBA:GO_Central.
DR   CDD; cd00085; HNHc; 1.
DR   Gene3D; 1.20.210.10; -; 1.
DR   InterPro; IPR023616; Cyt_c_oxase-like_su1_dom.
DR   InterPro; IPR036927; Cyt_c_oxase-like_su1_sf.
DR   InterPro; IPR000883; Cyt_C_Oxase_1.
DR   InterPro; IPR043502; DNA/RNA_pol_sf.
DR   InterPro; IPR024937; Domain_X.
DR   InterPro; IPR003615; HNH_nuc.
DR   InterPro; IPR000477; RT_dom.
DR   Pfam; PF01348; Intron_maturas2; 1.
DR   Pfam; PF00078; RVT_1; 1.
DR   PRINTS; PR01165; CYCOXIDASEI.
DR   SMART; SM00507; HNHc; 1.
DR   SUPFAM; SSF56672; SSF56672; 1.
DR   SUPFAM; SSF81442; SSF81442; 1.
DR   PROSITE; PS50855; COX1; 1.
DR   PROSITE; PS50878; RT_POL; 1.
PE   4: Predicted;
KW   Mitochondrion; Reference proteome.
FT   CHAIN           1..854
FT                   /note="Putative COX1/OXI3 intron 2 protein"
FT                   /id="PRO_0000196881"
FT   DOMAIN          329..613
FT                   /note="Reverse transcriptase"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00405"
FT   CONFLICT        236
FT                   /note="V -> A (in Ref. 1; CAA24060)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        724
FT                   /note="R -> S (in Ref. 1; CAA24060)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   854 AA;  98008 MW;  6E22D9B5ABCD43F2 CRC64;
     MVQRWLYSTN AKDIAVLYFM LAIFSGMAGT AMSLIIRLEL AAPGSQYLHG NSQLFNVLVV
     GHAVLMIFCA PFRLIYHCIE VLIDKHISVY SINENFTVSF WFWLLVVTYM VFRYVNHMAY
     PVGANSTGTM ACHKSAGVKQ PAQGKNCPMA RLTNSCKECL GFSLTPSHLG IVIHAYVLEE
     EVHELTKNES LALSKSWHLE GCTSSNGKLR NTGLSERGNP GDNGVFMVPK FNLNKVRYFS
     TLSKLNARKE DSLAYLTKIN TTDFSELNKL MENNHNKTET INTRILKLMS DIRMLLIAYN
     KIKSKKGNMS KGSNNITLDG INISYLNKLS KDINTNMFKF SPVRRVEIPK TSGGFRPLSV
     GNPREKIVQE SMRMMLEIIY NNSFSYYSHG FRPNLSCLTA IIQCKNYMQY CNWFIKVDLN
     KCFDTIPHNM LINVLNERIK DKGFMDLLYK LLRAGYVDKN NNYHNTTLGI PQGSVVSPIL
     CNIFLDKLDK YLENKFENEF NTGNMSNRGR NPIYNSLSSK IYRCKLLSEK LKLIRLRDHY
     QRNMGSDKSF KRAYFVRYAD DIIIGVMGSH NDCKNILNDI NNFLKENLGM SINMDKSVIK
     HSKEGVSFLG YDVKVTPWEK RPYRMIKKGD NFIRVRHHTS LVVNAPIRSI VMKLNKHGYC
     SHGILGKPRG VGRLIHEEMK TILMHYLAVG RGIMNYYRLA TNFTTLRGRI TYILFYSCCL
     TLARKFKLNT VKKVILKFGK VLVDPHSKVS FSIDDFKIRH KMNMTDSNYT PDEILDRYKY
     MLPRSLSLFS GICQICGSKH DLEVHHVRTL NNAANKIKDD YLLGRMIKMN RKQITICKTC
     HFKVHQGKYN GPGL