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AI3_DEBHA
ID   AI3_DEBHA               Reviewed;         687 AA.
AC   A9RAH6;
DT   25-NOV-2008, integrated into UniProtKB/Swiss-Prot.
DT   05-FEB-2008, sequence version 1.
DT   25-MAY-2022, entry version 70.
DE   RecName: Full=Probable intron-encoded endonuclease aI3;
DE   Contains:
DE     RecName: Full=Truncated non-functional cytochrome oxidase 1;
DE   Contains:
DE     RecName: Full=Intron-encoded endonuclease aI3;
DE              EC=3.1.-.-;
DE   Flags: Precursor;
GN   Name=aI3;
OS   Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990
OS   / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii).
OG   Mitochondrion.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Debaryomyces.
OX   NCBI_TaxID=284592;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968;
RX   PubMed=18673395; DOI=10.1111/j.1567-1364.2008.00409.x;
RA   Sacerdot C., Casaregola S., Lafontaine I., Tekaia F., Dujon B.,
RA   Ozier-Kalogeropoulos O.;
RT   "Promiscuous DNA in the nuclear genomes of hemiascomycetous yeasts.";
RL   FEMS Yeast Res. 8:846-857(2008).
CC   -!- FUNCTION: Mitochondrial DNA endonuclease involved in intron homing.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion. Membrane {ECO:0000305}; Multi-pass
CC       membrane protein {ECO:0000305}.
CC   -!- PTM: The mature protein may arise from proteolytic cleavage of an in-
CC       frame translation of COX1 exons 1 to 3 plus intron 3, containing the
CC       aI3 open reading frame.
CC   -!- SIMILARITY: In the C-terminal section; belongs to the LAGLIDADG
CC       endonuclease family. {ECO:0000305}.
CC   -!- SIMILARITY: In the N-terminal section; belongs to the heme-copper
CC       respiratory oxidase family. {ECO:0000305}.
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DR   EMBL; DQ508940; ABF58077.1; -; Genomic_DNA.
DR   RefSeq; YP_001621428.1; NC_010166.1.
DR   AlphaFoldDB; A9RAH6; -.
DR   SMR; A9RAH6; -.
DR   STRING; 284592.A9RAH6; -.
DR   GeneID; 5845853; -.
DR   InParanoid; A9RAH6; -.
DR   Proteomes; UP000000599; Mitochondrion.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.
DR   GO; GO:0004129; F:cytochrome-c oxidase activity; IEA:InterPro.
DR   GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.
DR   GO; GO:0020037; F:heme binding; IEA:InterPro.
DR   GO; GO:0009060; P:aerobic respiration; IEA:InterPro.
DR   GO; GO:0006314; P:intron homing; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.210.10; -; 1.
DR   Gene3D; 3.10.28.10; -; 2.
DR   InterPro; IPR023616; Cyt_c_oxase-like_su1_dom.
DR   InterPro; IPR036927; Cyt_c_oxase-like_su1_sf.
DR   InterPro; IPR000883; Cyt_C_Oxase_1.
DR   InterPro; IPR023615; Cyt_c_Oxase_su1_BS.
DR   InterPro; IPR027434; Homing_endonucl.
DR   InterPro; IPR004860; LAGLIDADG_2.
DR   PANTHER; PTHR10422; PTHR10422; 1.
DR   Pfam; PF00115; COX1; 1.
DR   Pfam; PF00961; LAGLIDADG_1; 2.
DR   PRINTS; PR01165; CYCOXIDASEI.
DR   SUPFAM; SSF55608; SSF55608; 2.
DR   SUPFAM; SSF81442; SSF81442; 1.
DR   PROSITE; PS50855; COX1; 1.
DR   PROSITE; PS00077; COX1_CUB; 1.
PE   3: Inferred from homology;
KW   Endonuclease; Hydrolase; Intron homing; Membrane; Mitochondrion; Nuclease;
KW   Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..?
FT                   /note="Truncated non-functional cytochrome oxidase 1"
FT                   /id="PRO_0000355039"
FT   CHAIN           ?..687
FT                   /note="Intron-encoded endonuclease aI3"
FT                   /id="PRO_0000355040"
FT   TRANSMEM        19..39
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        69..89
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        103..123
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        152..172
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        188..208
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        240..260
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        273..293
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        315..335
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        341..361
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        376..396
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          1..374
FT                   /note="COX1 exons 1 to 3 encoded"
FT   REGION          375..687
FT                   /note="COX1 intron 3 encoded"
SQ   SEQUENCE   687 AA;  78619 MW;  83FBA7AB0A329CD5 CRC64;
     MKQMSYVTRW LYSTSHKDIG MTYLGFGMLS AMMGTGMSVM MRMELSNGNS QFFHGNNQAF
     NVMMSGHALL MMFFFIMPVW MGAFGNFFLP MLMGAADMAF ARLNNISFWC LPPALVCMVC
     SVLMEQGAGT GFTTYPPLSS MSAHSGPSVD LAMFAMHLTS MSSLLGAMNF MVTVLNMRTM
     GLHMVNMPLF AWAMFLTAML LLLSLPVLTA AVTLLLMDRN FNTGFYEVGA GGDPVTYEHL
     FWFFGHPEVY ILMMPGFGVM SHMVSTYSKK PMFGEMGMLY AMGSIGFLGF LVWSHHMFVV
     GLDIDSRAYF TSATMVIAVP TGIKIFSWLA TIYGGELRLG VPMLFALGFL FLFTMGGLTG
     VMTSNASMDV AFHDRIFIYY VSFFLYTLYN MYNNYTNNNT AHKGRHCANA SYNNDINNLV
     SFMDKNEYIK MFWVGLMDGD GSMQVNHWRK KNLQYRLIMK TSNLESNYNM LMLMAKVMGG
     TVRISKKKDN VMWVVDSKES IKDMMKMFDK YPLLTSRKMC QINFMKKCMK LNYMPAEGGY
     PREAGTDWYL LNRNYKYNDQ LNMINTFNLK LKNKSFMNAL PEGHGMHHMV KHSEYFKCWL
     SGFMEAEGCF SIRLNKSNSF SMGQNDDFYL MEEIKQFFNA TNSVRNSYKN FYCLEIYKRI
     MLNNIITHCS NYPLLGEKKE SLMKFLK
 
 
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