ID   AI3_DICDI               Reviewed;         232 AA.
AC   O21045;
DT   04-DEC-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1998, sequence version 1.
DT   25-MAY-2022, entry version 78.
DE   RecName: Full=Probable intron-encoded endonuclease aI3;
DE            EC=3.1.-.-;
DE   AltName: Full=Cox1/2 intron3 ORF;
GN   Name=aI3; ORFNames=DDB_G0294425;
OS   Dictyostelium discoideum (Slime mold).
OG   Mitochondrion.
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=AX3;
RX   PubMed=9000384; DOI=10.1007/s002940050179;
RA   Ogawa S., Matsuo K., Angata K., Yanagisawa K., Tanaka Y.;
RT   "Group-I introns in the cytochrome c oxidase genes of Dictyostelium
RT   discoideum: two related ORFs in one loop of a group-I intron, a cox1/2
RT   hybrid gene and an unusually large cox3 gene.";
RL   Curr. Genet. 31:80-88(1997).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX3;
RX   PubMed=10821186; DOI=10.1007/pl00008685;
RA   Ogawa S., Yoshino R., Angata K., Iwamoto M., Pi M., Kuroe K., Matsuo K.,
RA   Morio T., Urushihara H., Yanagisawa K., Tanaka Y.;
RT   "The mitochondrial DNA of Dictyostelium discoideum: complete sequence, gene
RT   content and genome organization.";
RL   Mol. Gen. Genet. 263:514-519(2000).
CC   -!- FUNCTION: Mitochondrial DNA endonuclease involved in intron homing.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the LAGLIDADG endonuclease family.
CC       {ECO:0000305}.
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DR   EMBL; D50297; BAA21126.1; -; Genomic_DNA.
DR   EMBL; AB000109; BAA78058.1; -; Genomic_DNA.
DR   PIR; T43754; T43754.
DR   RefSeq; NP_050076.1; NC_000895.1.
DR   AlphaFoldDB; O21045; -.
DR   SMR; O21045; -.
DR   GeneID; 2193942; -.
DR   KEGG; ddi:DidioMp09; -.
DR   dictyBase; DDB_G0294425; ai3.
DR   InParanoid; O21045; -.
DR   PhylomeDB; O21045; -.
DR   PRO; PR:O21045; -.
DR   Proteomes; UP000002195; Mitochondrion.
DR   GO; GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.
DR   GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.
DR   GO; GO:0006314; P:intron homing; IEA:UniProtKB-KW.
DR   Gene3D; 3.10.28.10; -; 2.
DR   InterPro; IPR027434; Homing_endonucl.
DR   InterPro; IPR004860; LAGLIDADG_2.
DR   Pfam; PF00961; LAGLIDADG_1; 2.
DR   SUPFAM; SSF55608; SSF55608; 2.
PE   3: Inferred from homology;
KW   Endonuclease; Hydrolase; Intron homing; Mitochondrion; Nuclease;
KW   Reference proteome.
FT   CHAIN           1..232
FT                   /note="Probable intron-encoded endonuclease aI3"
FT                   /id="PRO_0000312715"
SQ   SEQUENCE   232 AA;  27932 MW;  50A69E1E4F12147B CRC64;
     MKVEEREYIK KYWVGLMDGV GSIEVNHYRM KNLQYRLVLN VNDSSENMAM LLKIQQVIGG
     YLIKRKEKAL IAWTINNKMQ IEDVIKIFED YNLVTVRKRN QLQFLKENLK RNDVNWYLSE
     RKNKYKKSLI VSNIEEISYF NEWFSGFVEA TGSFCIRAQK EKYFRIAHRY DMPLLLNLII
     KFNITTKLRE QKNEQYAIEI YKKTLLEVLI THFEKYPLLG DKKNSLETFK TR