ID   FABP1_AMBME             Reviewed;         126 AA.
AC   P81399;
DT   15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT   15-JUL-1998, sequence version 1.
DT   25-MAY-2022, entry version 74.
DE   RecName: Full=Fatty acid-binding protein 1, liver;
DE   AltName: Full=Liver-type fatty acid-binding protein;
DE            Short=L-FABP;
OS   Ambystoma mexicanum (Axolotl).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Caudata; Salamandroidea; Ambystomatidae; Ambystoma.
OX   NCBI_TaxID=8296;
RN   [1]
RP   PROTEIN SEQUENCE.
RC   TISSUE=Liver;
RX   PubMed=9914484; DOI=10.1046/j.1432-1327.1999.00015.x;
RA   Di Pietro S.M., Veerkamp J.H., Santome J.A.;
RT   "Isolation, amino acid sequence determination and binding properties of two
RT   fatty-acid-binding proteins from axolotl (Ambistoma mexicanum) liver.
RT   Evolutionary relationship.";
RL   Eur. J. Biochem. 259:127-134(1999).
CC   -!- FUNCTION: Binds free fatty acids and their coenzyme A derivatives,
CC       bilirubin, and some other small molecules in the cytoplasm. May be
CC       involved in intracellular lipid transport (By similarity). The
CC       specificity of axolotl L-FABP differs from that of LB-FABP.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm.
CC   -!- DOMAIN: Forms a beta-barrel structure that accommodates hydrophobic
CC       ligands in its interior. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the calycin superfamily. Fatty-acid binding
CC       protein (FABP) family. {ECO:0000305}.
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DR   AlphaFoldDB; P81399; -.
DR   SMR; P81399; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005504; F:fatty acid binding; IEA:InterPro.
DR   Gene3D; 2.40.128.20; -; 1.
DR   InterPro; IPR012674; Calycin.
DR   InterPro; IPR000463; Fatty_acid-bd.
DR   InterPro; IPR031259; ILBP.
DR   InterPro; IPR031276; Lb-FABP.
DR   PANTHER; PTHR11955; PTHR11955; 1.
DR   PANTHER; PTHR11955:SF96; PTHR11955:SF96; 1.
DR   PRINTS; PR00178; FATTYACIDBP.
DR   SUPFAM; SSF50814; SSF50814; 1.
DR   PROSITE; PS00214; FABP; 1.
PE   1: Evidence at protein level;
KW   Cytoplasm; Direct protein sequencing; Lipid-binding; Transport.
FT   CHAIN           1..126
FT                   /note="Fatty acid-binding protein 1, liver"
FT                   /id="PRO_0000067343"
SQ   SEQUENCE   126 AA;  13915 MW;  DC025A9CDC47C744 CRC64;
     SFAGKYELQS QENFEAFMKA IGLPDELIQK GKDIKSVSEI QQNGKSFKVT VTTGSKVLEN
     EFTLGEEAEL ETLTGEKVKS IVKQEGDNKL VVNLKGITSV TELSGDTLIN TLQKGDDTYK
     RISKRI