ID   FABP1_MANSE             Reviewed;         132 AA.
AC   P31416;
DT   01-JUL-1993, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-1993, sequence version 1.
DT   03-AUG-2022, entry version 84.
DE   RecName: Full=Fatty acid-binding protein 1;
DE            Short=FABP 1;
GN   Name=MFB1;
OS   Manduca sexta (Tobacco hawkmoth) (Tobacco hornworm).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Lepidoptera; Glossata; Ditrysia; Bombycoidea;
OC   Sphingidae; Sphinginae; Sphingini; Manduca.
OX   NCBI_TaxID=7130;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Midgut;
RX   PubMed=1730603; DOI=10.1016/s0021-9258(18)48505-5;
RA   Smith A.F., Tsuchida K., Hanneman E., Suzuki T.C., Wells M.A.;
RT   "Isolation, characterization, and cDNA sequence of two fatty acid-binding
RT   proteins from the midgut of Manduca sexta larvae.";
RL   J. Biol. Chem. 267:380-384(1992).
CC   -!- FUNCTION: Binds fatty acids in a 1:1 molar ratio.
CC   -!- SUBUNIT: Monomer.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm.
CC   -!- TISSUE SPECIFICITY: Midgut.
CC   -!- DOMAIN: Forms a beta-barrel structure that accommodates hydrophobic
CC       ligands in its interior. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the calycin superfamily. Fatty-acid binding
CC       protein (FABP) family. {ECO:0000305}.
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DR   EMBL; M77754; AAA29313.1; -; mRNA.
DR   PIR; A41749; A41749.
DR   AlphaFoldDB; P31416; -.
DR   SMR; P31416; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0008289; F:lipid binding; IEA:UniProtKB-KW.
DR   Gene3D; 2.40.128.20; -; 1.
DR   InterPro; IPR012674; Calycin.
DR   InterPro; IPR000463; Fatty_acid-bd.
DR   InterPro; IPR031259; ILBP.
DR   PANTHER; PTHR11955; PTHR11955; 1.
DR   SUPFAM; SSF50814; SSF50814; 1.
DR   PROSITE; PS00214; FABP; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Lipid-binding; Transport.
FT   CHAIN           1..132
FT                   /note="Fatty acid-binding protein 1"
FT                   /id="PRO_0000067360"
FT   BINDING         106
FT                   /ligand="a fatty acid"
FT                   /ligand_id="ChEBI:CHEBI:28868"
FT                   /evidence="ECO:0000250|UniProtKB:Q02970"
FT   BINDING         128..130
FT                   /ligand="a fatty acid"
FT                   /ligand_id="ChEBI:CHEBI:28868"
FT                   /evidence="ECO:0000250|UniProtKB:Q02970"
SQ   SEQUENCE   132 AA;  14834 MW;  86A40381CD7B4F54 CRC64;
     MAYLGKVYKF DREENFDGFL KSIGLSEEQV QKYLQYKPSS QLVKEGDKYK YISVSSDGTK
     ETVFESGVET DDVVQGGLPI KTTYTVDGNT VTQVVNSAQG SATFKREYNG DELKVTITSS
     EWDGVAYRYY KA