ID   FABP2_CAEEL             Reviewed;         161 AA.
AC   Q20224;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1997, sequence version 1.
DT   03-AUG-2022, entry version 118.
DE   RecName: Full=Fatty acid-binding protein homolog 2;
DE   AltName: Full=Lipid-binding protein 2;
DE   Flags: Precursor;
GN   Name=lbp-2; ORFNames=F40F4.2;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
RN   [2]
RP   PROTEIN SEQUENCE OF 20-37.
RC   STRAIN=Bristol N2;
RX   PubMed=9150941; DOI=10.1002/elps.1150180337;
RA   Bini L., Heid H., Liberatori S., Geier G., Pallini V., Zwilling R.;
RT   "Two-dimensional gel electrophoresis of Caenorhabditis elegans homogenates
RT   and identification of protein spots by microsequencing.";
RL   Electrophoresis 18:557-562(1997).
RN   [3]
RP   FUNCTION, AND SUBCELLULAR LOCATION.
RX   PubMed=10693745; DOI=10.1016/s0166-6851(99)00179-6;
RA   Plenefisch J., Xiao H., Mei B., Geng J., Komuniecki P.R., Komuniecki R.;
RT   "Secretion of a novel class of iFABPs in nematodes: coordinate use of the
RT   Ascaris/Caenorhabditis model systems.";
RL   Mol. Biochem. Parasitol. 105:223-236(2000).
CC   -!- FUNCTION: May play a role in sequestering potentially toxic fatty acids
CC       and their peroxidation products, or it may be involved in the
CC       maintenance of the impermeable lipid layer of the eggshell.
CC       {ECO:0000269|PubMed:10693745}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:10693745}. Note=From
CC       muscle into the perienteric fluid.
CC   -!- DOMAIN: Forms a beta-barrel structure that accommodates hydrophobic
CC       ligands in its interior. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the calycin superfamily. Fatty-acid binding
CC       protein (FABP) family. {ECO:0000305}.
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DR   EMBL; FO081243; CCD70141.1; -; Genomic_DNA.
DR   PIR; T16310; T16310.
DR   RefSeq; NP_508558.1; NM_076157.7.
DR   AlphaFoldDB; Q20224; -.
DR   SMR; Q20224; -.
DR   BioGRID; 45558; 42.
DR   IntAct; Q20224; 1.
DR   STRING; 6239.F40F4.2.2; -.
DR   EPD; Q20224; -.
DR   PaxDb; Q20224; -.
DR   PeptideAtlas; Q20224; -.
DR   EnsemblMetazoa; F40F4.2.1; F40F4.2.1; WBGene00002254.
DR   EnsemblMetazoa; F40F4.2.2; F40F4.2.2; WBGene00002254.
DR   GeneID; 180617; -.
DR   KEGG; cel:CELE_F40F4.2; -.
DR   UCSC; F40F4.2.1; c. elegans.
DR   CTD; 180617; -.
DR   WormBase; F40F4.2; CE04532; WBGene00002254; lbp-2.
DR   eggNOG; KOG4015; Eukaryota.
DR   GeneTree; ENSGT00390000007345; -.
DR   HOGENOM; CLU_113772_2_1_1; -.
DR   InParanoid; Q20224; -.
DR   OMA; RFHMEED; -.
DR   OrthoDB; 1520038at2759; -.
DR   PhylomeDB; Q20224; -.
DR   PRO; PR:Q20224; -.
DR   Proteomes; UP000001940; Chromosome X.
DR   Bgee; WBGene00002254; Expressed in adult organism and 4 other tissues.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0008289; F:lipid binding; IEA:UniProtKB-KW.
DR   Gene3D; 2.40.128.20; -; 1.
DR   InterPro; IPR012674; Calycin.
DR   InterPro; IPR000463; Fatty_acid-bd.
DR   InterPro; IPR040094; Lbp1-4.
DR   PANTHER; PTHR22725; PTHR22725; 1.
DR   PRINTS; PR00178; FATTYACIDBP.
DR   SUPFAM; SSF50814; SSF50814; 1.
DR   PROSITE; PS00214; FABP; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Lipid-binding; Reference proteome; Secreted;
KW   Signal; Transport.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000269|PubMed:9150941"
FT   CHAIN           20..161
FT                   /note="Fatty acid-binding protein homolog 2"
FT                   /id="PRO_0000008738"
SQ   SEQUENCE   161 AA;  18843 MW;  0A00AAD416C69879 CRC64;
     MSSKFLILLA FCGATLVAAE QLPEKFYGTF DLDHSENFDE YLTAKGYGWF TRKLVTFATF
     KKVFAKNANK NLFDYSNLTS KKDVFYKNVQ IGSKFEGEGL DNTKHEVTFT LKDGHLFEHH
     KPLEEGESKE ETYEYYFDGD FLIQKMSFNN IEGRRFYKRL P