ID   FABP7_CHICK             Reviewed;         132 AA.
AC   Q05423;
DT   01-FEB-1994, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 2.
DT   03-AUG-2022, entry version 130.
DE   RecName: Full=Fatty acid-binding protein, brain;
DE   AltName: Full=Brain-type fatty acid-binding protein;
DE            Short=B-FABP;
DE   AltName: Full=Fatty acid-binding protein 7;
DE   AltName: Full=Fatty acid-binding protein, retina;
DE   AltName: Full=R-FABP;
GN   Name=FABP7;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND DEVELOPMENTAL STAGE.
RC   TISSUE=Embryonic retina;
RX   PubMed=7916696; DOI=10.1006/exer.1993.1014;
RA   Godbout R.;
RT   "Identification and characterization of transcripts present at elevated
RT   levels in the undifferentiated chick retina.";
RL   Exp. Eye Res. 56:95-106(1993).
CC   -!- FUNCTION: FABP are thought to play a role in the intracellular
CC       transport of long-chain fatty acids and their acyl-CoA esters.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- DEVELOPMENTAL STAGE: Highest expression in early stages of retinal
CC       development with a 50-100 fold decrease from day 3 to day 19 of retina
CC       maturation. {ECO:0000269|PubMed:7916696}.
CC   -!- DOMAIN: Forms a beta-barrel structure that accommodates hydrophobic
CC       ligands in its interior. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the calycin superfamily. Fatty-acid binding
CC       protein (FABP) family. {ECO:0000305}.
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DR   EMBL; X65459; CAA46451.1; -; mRNA.
DR   PIR; A49184; A49184.
DR   RefSeq; NP_990639.1; NM_205308.2.
DR   AlphaFoldDB; Q05423; -.
DR   SMR; Q05423; -.
DR   STRING; 9031.ENSGALP00000023941; -.
DR   PaxDb; Q05423; -.
DR   Ensembl; ENSGALT00000084998; ENSGALP00000062776; ENSGALG00000038933.
DR   GeneID; 396246; -.
DR   KEGG; gga:396246; -.
DR   CTD; 2173; -.
DR   VEuPathDB; HostDB:geneid_396246; -.
DR   eggNOG; KOG4015; Eukaryota.
DR   GeneTree; ENSGT00940000156713; -.
DR   HOGENOM; CLU_113772_0_0_1; -.
DR   InParanoid; Q05423; -.
DR   OMA; KDDKMVM; -.
DR   OrthoDB; 1417203at2759; -.
DR   PhylomeDB; Q05423; -.
DR   Reactome; R-GGA-163560; Triglyceride catabolism.
DR   PRO; PR:Q05423; -.
DR   Proteomes; UP000000539; Chromosome 3.
DR   Bgee; ENSGALG00000038933; Expressed in kidney and 10 other tissues.
DR   ExpressionAtlas; Q05423; baseline and differential.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0005504; F:fatty acid binding; IBA:GO_Central.
DR   GO; GO:0008134; F:transcription factor binding; TAS:AgBase.
DR   GO; GO:0007420; P:brain development; TAS:AgBase.
DR   GO; GO:0015908; P:fatty acid transport; IBA:GO_Central.
DR   GO; GO:0003407; P:neural retina development; TAS:AgBase.
DR   Gene3D; 2.40.128.20; -; 1.
DR   InterPro; IPR012674; Calycin.
DR   InterPro; IPR000463; Fatty_acid-bd.
DR   InterPro; IPR031259; ILBP.
DR   InterPro; IPR000566; Lipocln_cytosolic_FA-bd_dom.
DR   PANTHER; PTHR11955; PTHR11955; 1.
DR   Pfam; PF00061; Lipocalin; 1.
DR   PRINTS; PR00178; FATTYACIDBP.
DR   SUPFAM; SSF50814; SSF50814; 1.
DR   PROSITE; PS00214; FABP; 1.
PE   2: Evidence at transcript level;
KW   Acetylation; Cytoplasm; Lipid-binding; Reference proteome; Transport.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000250"
FT   CHAIN           2..132
FT                   /note="Fatty acid-binding protein, brain"
FT                   /id="PRO_0000067371"
FT   BINDING         127..129
FT                   /ligand="a fatty acid"
FT                   /ligand_id="ChEBI:CHEBI:28868"
FT                   /evidence="ECO:0000250"
FT   MOD_RES         2
FT                   /note="N-acetylvaline"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   132 AA;  14927 MW;  FE84481C2C64BEA8 CRC64;
     MVEAFCATWK LADSHNFDEY MKALGVGFAM RQVGNVTKPT VIISSEGDKV VIRTQSTFKN
     TEISFKLGEE FDETTPDDRN CKSVVTLDGD KLVHVQKWDG KETNFVREIK DGRMVMTLTF
     GDVVAVRHYE KA