ID   FABR_ECOHS              Reviewed;         215 AA.
AC   A8A771;
DT   05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   23-OCT-2007, sequence version 1.
DT   25-MAY-2022, entry version 76.
DE   RecName: Full=HTH-type transcriptional repressor FabR {ECO:0000255|HAMAP-Rule:MF_01190};
GN   Name=fabR {ECO:0000255|HAMAP-Rule:MF_01190}; OrderedLocusNames=EcHS_A4197;
OS   Escherichia coli O9:H4 (strain HS).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=331112;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=HS;
RX   PubMed=18676672; DOI=10.1128/jb.00619-08;
RA   Rasko D.A., Rosovitz M.J., Myers G.S.A., Mongodin E.F., Fricke W.F.,
RA   Gajer P., Crabtree J., Sebaihia M., Thomson N.R., Chaudhuri R.,
RA   Henderson I.R., Sperandio V., Ravel J.;
RT   "The pangenome structure of Escherichia coli: comparative genomic analysis
RT   of E. coli commensal and pathogenic isolates.";
RL   J. Bacteriol. 190:6881-6893(2008).
CC   -!- FUNCTION: Represses the transcription of fabB, involved in unsaturated
CC       fatty acid (UFA) biosynthesis. By controlling UFA production, FabR
CC       directly influences the physical properties of the membrane bilayer.
CC       {ECO:0000255|HAMAP-Rule:MF_01190}.
CC   -!- SUBUNIT: Homodimer. {ECO:0000255|HAMAP-Rule:MF_01190}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01190}.
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DR   EMBL; CP000802; ABV08375.1; -; Genomic_DNA.
DR   AlphaFoldDB; A8A771; -.
DR   SMR; A8A771; -.
DR   KEGG; ecx:EcHS_A4197; -.
DR   HOGENOM; CLU_081861_0_0_6; -.
DR   OMA; REHWRFI; -.
DR   Proteomes; UP000001123; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006633; P:fatty acid biosynthetic process; IEA:UniProtKB-UniRule.
DR   GO; GO:0045717; P:negative regulation of fatty acid biosynthetic process; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_01190; HTH_type_FabR; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR001647; HTH_TetR.
DR   InterPro; IPR023764; Tscrpt_reg_HTH_FabR.
DR   Pfam; PF00440; TetR_N; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS50977; HTH_TETR_2; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; DNA-binding; Fatty acid biosynthesis; Fatty acid metabolism;
KW   Lipid biosynthesis; Lipid metabolism; Repressor; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..215
FT                   /note="HTH-type transcriptional repressor FabR"
FT                   /id="PRO_1000065869"
FT   DOMAIN          10..70
FT                   /note="HTH tetR-type"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01190"
FT   DNA_BIND        33..52
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01190"
SQ   SEQUENCE   215 AA;  24418 MW;  ACA9739EB06F40C5 CRC64;
     MGVRAQQKEK TRRSLVEAAF SQLSAERSFA SLSLREVARE AGIAPTSFYR HFRDVDELGL
     TMVDESGLML RQLMRQARQR IAKGGSVIRT SVSTFMEFIG NNPNAFRLLL RERSGTSAAF
     RAAVAREIQH FIAELADYLE LENHMPRAFT EAQAEAMVTI VFSAGAEALD IGVEQRRQLE
     ERLVLQLRMI SKGAYYWYRR EQEKTAIIPG NVKDE