FABR_ECOL6
ID FABR_ECOL6 Reviewed; 215 AA.
AC Q8FB90;
DT 10-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT 10-JUL-2007, sequence version 2.
DT 25-MAY-2022, entry version 97.
DE RecName: Full=HTH-type transcriptional repressor FabR {ECO:0000255|HAMAP-Rule:MF_01190};
GN Name=fabR {ECO:0000255|HAMAP-Rule:MF_01190}; OrderedLocusNames=c4926;
OS Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=199310;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CFT073 / ATCC 700928 / UPEC;
RX PubMed=12471157; DOI=10.1073/pnas.252529799;
RA Welch R.A., Burland V., Plunkett G. III, Redford P., Roesch P., Rasko D.,
RA Buckles E.L., Liou S.-R., Boutin A., Hackett J., Stroud D., Mayhew G.F.,
RA Rose D.J., Zhou S., Schwartz D.C., Perna N.T., Mobley H.L.T.,
RA Donnenberg M.S., Blattner F.R.;
RT "Extensive mosaic structure revealed by the complete genome sequence of
RT uropathogenic Escherichia coli.";
RL Proc. Natl. Acad. Sci. U.S.A. 99:17020-17024(2002).
CC -!- FUNCTION: Represses the transcription of fabB, involved in unsaturated
CC fatty acid (UFA) biosynthesis. By controlling UFA production, FabR
CC directly influences the physical properties of the membrane bilayer.
CC {ECO:0000255|HAMAP-Rule:MF_01190}.
CC -!- SUBUNIT: Homodimer. {ECO:0000255|HAMAP-Rule:MF_01190}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01190}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAN83354.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AE014075; AAN83354.1; ALT_INIT; Genomic_DNA.
DR AlphaFoldDB; Q8FB90; -.
DR SMR; Q8FB90; -.
DR STRING; 199310.c4926; -.
DR EnsemblBacteria; AAN83354; AAN83354; c4926.
DR KEGG; ecc:c4926; -.
DR eggNOG; COG1309; Bacteria.
DR HOGENOM; CLU_081861_0_0_6; -.
DR Proteomes; UP000001410; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006633; P:fatty acid biosynthetic process; IEA:UniProtKB-UniRule.
DR GO; GO:0045717; P:negative regulation of fatty acid biosynthetic process; IEA:UniProtKB-UniRule.
DR HAMAP; MF_01190; HTH_type_FabR; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR001647; HTH_TetR.
DR InterPro; IPR023764; Tscrpt_reg_HTH_FabR.
DR Pfam; PF00440; TetR_N; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR PROSITE; PS50977; HTH_TETR_2; 1.
PE 3: Inferred from homology;
KW Cytoplasm; DNA-binding; Fatty acid biosynthesis; Fatty acid metabolism;
KW Lipid biosynthesis; Lipid metabolism; Repressor; Transcription;
KW Transcription regulation.
FT CHAIN 1..215
FT /note="HTH-type transcriptional repressor FabR"
FT /id="PRO_0000293568"
FT DOMAIN 10..70
FT /note="HTH tetR-type"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01190"
FT DNA_BIND 33..52
FT /note="H-T-H motif"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01190"
SQ SEQUENCE 215 AA; 24434 MW; ACB9729EA947E256 CRC64;
MGVRAQQKEK TRRSLVEAAF SQLSAERSFA SLSLREVARE AGIAPTSFYR HFRDVDELGL
TMVDESGLML RQLMRQARQR IAKGGSVIRT SVSTFMEFIG NNPNAFRLLL RERSGTSAAF
RAAVAREIQH FIAELADYLE LENHMPRAFT EAQAEAMVTI VFSAGAEALD VGVEQRRQLE
ERLVLQLRMI SKGAYYWYRR EQEKTTIIPG NVKDE