AIB_ARATH
ID AIB_ARATH Reviewed; 566 AA.
AC Q9ZPY8; Q8LPT0;
DT 16-DEC-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2002, sequence version 2.
DT 03-AUG-2022, entry version 136.
DE RecName: Full=Transcription factor ABA-INDUCIBLE bHLH-TYPE;
DE Short=AtAIB;
DE AltName: Full=Basic helix-loop-helix protein 17;
DE Short=AtbHLH17;
DE Short=bHLH 17;
DE AltName: Full=Transcription factor EN 35;
DE AltName: Full=bHLH transcription factor bHLH017;
GN Name=AIB; Synonyms=BHLH17, EN35; OrderedLocusNames=At2g46510;
GN ORFNames=F13A10.4;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10617197; DOI=10.1038/45471;
RA Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D.,
RA Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V.,
RA Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L., Moffat K.S.,
RA Cronin L.A., Shen M., Pai G., Van Aken S., Umayam L., Tallon L.J.,
RA Gill J.E., Adams M.D., Carrera A.J., Creasy T.H., Goodman H.M.,
RA Somerville C.R., Copenhaver G.P., Preuss D., Nierman W.C., White O.,
RA Eisen J.A., Salzberg S.L., Fraser C.M., Venter J.C.;
RT "Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana.";
RL Nature 402:761-768(1999).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [4]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=12679534; DOI=10.1093/molbev/msg088;
RA Heim M.A., Jakoby M., Werber M., Martin C., Weisshaar B., Bailey P.C.;
RT "The basic helix-loop-helix transcription factor family in plants: a
RT genome-wide study of protein structure and functional diversity.";
RL Mol. Biol. Evol. 20:735-747(2003).
RN [5]
RP GENE FAMILY.
RX PubMed=12897250; DOI=10.1105/tpc.013839;
RA Toledo-Ortiz G., Huq E., Quail P.H.;
RT "The Arabidopsis basic/helix-loop-helix transcription factor family.";
RL Plant Cell 15:1749-1770(2003).
RN [6]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=14600211; DOI=10.1105/tpc.151140;
RA Bailey P.C., Martin C., Toledo-Ortiz G., Quail P.H., Huq E., Heim M.A.,
RA Jakoby M., Werber M., Weisshaar B.;
RT "Update on the basic helix-loop-helix transcription factor gene family in
RT Arabidopsis thaliana.";
RL Plant Cell 15:2497-2502(2003).
RN [7]
RP FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, AND INDUCTION.
RX PubMed=17828375; DOI=10.1007/s11103-007-9230-3;
RA Li H., Sun J., Xu Y., Jiang H., Wu X., Li C.;
RT "The bHLH-type transcription factor AtAIB positively regulates ABA response
RT in Arabidopsis.";
RL Plant Mol. Biol. 65:655-665(2007).
CC -!- FUNCTION: Transcription activator. Regulates positively abscisic acid
CC (ABA) response. Confers drought tolerance and sensitivity to ABA.
CC {ECO:0000269|PubMed:17828375}.
CC -!- SUBUNIT: Homodimer. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981,
CC ECO:0000269|PubMed:17828375}.
CC -!- TISSUE SPECIFICITY: In seedlings, mainly expressed in root tips,
CC cotyledons, hypocotyls, and leaves, as well as its guard cells. In
CC adult plant, detectable in stems, flowers, and siliques.
CC {ECO:0000269|PubMed:17828375}.
CC -!- INDUCTION: Transiently by ABA and polyethylene glycol (PEG).
CC {ECO:0000269|PubMed:17828375}.
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DR EMBL; AC006418; AAD20162.2; -; Genomic_DNA.
DR EMBL; AC006526; AAM15265.1; -; Genomic_DNA.
DR EMBL; CP002685; AEC10712.1; -; Genomic_DNA.
DR EMBL; AY094399; AAM19778.1; -; mRNA.
DR PIR; G84903; G84903.
DR RefSeq; NP_566078.1; NM_130216.3.
DR AlphaFoldDB; Q9ZPY8; -.
DR SMR; Q9ZPY8; -.
DR BioGRID; 4597; 10.
DR STRING; 3702.AT2G46510.1; -.
DR PaxDb; Q9ZPY8; -.
DR PRIDE; Q9ZPY8; -.
DR ProteomicsDB; 244944; -.
DR EnsemblPlants; AT2G46510.1; AT2G46510.1; AT2G46510.
DR GeneID; 819262; -.
DR Gramene; AT2G46510.1; AT2G46510.1; AT2G46510.
DR KEGG; ath:AT2G46510; -.
DR Araport; AT2G46510; -.
DR TAIR; locus:2039094; AT2G46510.
DR eggNOG; ENOG502QUFW; Eukaryota.
DR HOGENOM; CLU_021132_0_1_1; -.
DR InParanoid; Q9ZPY8; -.
DR OMA; DWPNSEN; -.
DR OrthoDB; 828530at2759; -.
DR PhylomeDB; Q9ZPY8; -.
DR PRO; PR:Q9ZPY8; -.
DR Proteomes; UP000006548; Chromosome 2.
DR ExpressionAtlas; Q9ZPY8; baseline and differential.
DR Genevisible; Q9ZPY8; AT.
DR GO; GO:0005634; C:nucleus; IDA:TAIR.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IDA:TAIR.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR GO; GO:0000976; F:transcription cis-regulatory region binding; IPI:TAIR.
DR GO; GO:0009738; P:abscisic acid-activated signaling pathway; IEA:UniProtKB-KW.
DR GO; GO:0010629; P:negative regulation of gene expression; IGI:TAIR.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IBA:GO_Central.
DR GO; GO:0009737; P:response to abscisic acid; IMP:TAIR.
DR GO; GO:0009611; P:response to wounding; IEP:TAIR.
DR Gene3D; 4.10.280.10; -; 1.
DR InterPro; IPR045084; AIB/MYC-like.
DR InterPro; IPR011598; bHLH_dom.
DR InterPro; IPR036638; HLH_DNA-bd_sf.
DR InterPro; IPR025610; MYC/MYB_N.
DR PANTHER; PTHR11514; PTHR11514; 1.
DR Pfam; PF14215; bHLH-MYC_N; 1.
DR Pfam; PF00010; HLH; 1.
DR SMART; SM00353; HLH; 1.
DR SUPFAM; SSF47459; SSF47459; 1.
DR PROSITE; PS50888; BHLH; 1.
PE 2: Evidence at transcript level;
KW Abscisic acid signaling pathway; Activator; DNA-binding; Nucleus;
KW Reference proteome; Transcription; Transcription regulation.
FT CHAIN 1..566
FT /note="Transcription factor ABA-INDUCIBLE bHLH-TYPE"
FT /id="PRO_0000358722"
FT DOMAIN 391..440
FT /note="bHLH"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00981"
FT REGION 337..360
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 375..402
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 546..566
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 337..352
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 399
FT /note="A -> V (in Ref. 3; AAM19778)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 566 AA; 63305 MW; 5F8998F8A0D8239D CRC64;
MNMSDLGWDD EDKSVVSAVL GHLASDFLRA NSNSNQNLFL VMGTDDTLNK KLSSLVDWPN
SENFSWNYAI FWQQTMSRSG QQVLGWGDGC CREPNEEEES KVVRSYNFNN MGAEEETWQD
MRKRVLQKLH RLFGGSDEDN YALSLEKVTA TEIFFLASMY FFFNHGEGGP GRCYSSGKHV
WLSDAVNSES DYCFRSFMAK SAGIRTIVMV PTDAGVLELG SVWSLPENIG LVKSVQALFM
RRVTQPVMVT SNTNMTGGIH KLFGQDLSGA HAYPKKLEVR RNLDERFTPQ SWEGYNNNKG
PTFGYTPQRD DVKVLENVNM VVDNNNYKTQ IEFAGSSVAA SSNPSTNTQQ EKSESCTEKR
PVSLLAGAGI VSVVDEKRPR KRGRKPANGR EEPLNHVEAE RQRREKLNQR FYALRSVVPN
ISKMDKASLL GDAISYIKEL QEKVKIMEDE RVGTDKSLSE SNTITVEESP EVDIQAMNEE
VVVRVISPLD SHPASRIIQA MRNSNVSLME AKLSLAEDTM FHTFVIKSNN GSDPLTKEKL
IAAFYPETSS TQPPLPSSSS QVSGDI
