FABR_SHIFL
ID FABR_SHIFL Reviewed; 215 AA.
AC P0ACU6; P27307;
DT 22-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT 22-NOV-2005, sequence version 1.
DT 25-MAY-2022, entry version 96.
DE RecName: Full=HTH-type transcriptional repressor FabR {ECO:0000255|HAMAP-Rule:MF_01190};
GN Name=fabR {ECO:0000255|HAMAP-Rule:MF_01190};
GN OrderedLocusNames=SF4045, S3699;
OS Shigella flexneri.
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Shigella.
OX NCBI_TaxID=623;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=301 / Serotype 2a;
RX PubMed=12384590; DOI=10.1093/nar/gkf566;
RA Jin Q., Yuan Z., Xu J., Wang Y., Shen Y., Lu W., Wang J., Liu H., Yang J.,
RA Yang F., Zhang X., Zhang J., Yang G., Wu H., Qu D., Dong J., Sun L.,
RA Xue Y., Zhao A., Gao Y., Zhu J., Kan B., Ding K., Chen S., Cheng H.,
RA Yao Z., He B., Chen R., Ma D., Qiang B., Wen Y., Hou Y., Yu J.;
RT "Genome sequence of Shigella flexneri 2a: insights into pathogenicity
RT through comparison with genomes of Escherichia coli K12 and O157.";
RL Nucleic Acids Res. 30:4432-4441(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 700930 / 2457T / Serotype 2a;
RX PubMed=12704152; DOI=10.1128/iai.71.5.2775-2786.2003;
RA Wei J., Goldberg M.B., Burland V., Venkatesan M.M., Deng W., Fournier G.,
RA Mayhew G.F., Plunkett G. III, Rose D.J., Darling A., Mau B., Perna N.T.,
RA Payne S.M., Runyen-Janecky L.J., Zhou S., Schwartz D.C., Blattner F.R.;
RT "Complete genome sequence and comparative genomics of Shigella flexneri
RT serotype 2a strain 2457T.";
RL Infect. Immun. 71:2775-2786(2003).
CC -!- FUNCTION: Represses the transcription of fabB, involved in unsaturated
CC fatty acid (UFA) biosynthesis. By controlling UFA production, FabR
CC directly influences the physical properties of the membrane bilayer.
CC {ECO:0000255|HAMAP-Rule:MF_01190}.
CC -!- SUBUNIT: Homodimer. {ECO:0000255|HAMAP-Rule:MF_01190}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01190}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAN45474.2; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
CC Sequence=AAP18728.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AE005674; AAN45474.2; ALT_INIT; Genomic_DNA.
DR EMBL; AE014073; AAP18728.1; ALT_INIT; Genomic_DNA.
DR RefSeq; NP_709767.2; NC_004337.2.
DR RefSeq; WP_001300495.1; NZ_WPGW01000135.1.
DR AlphaFoldDB; P0ACU6; -.
DR SMR; P0ACU6; -.
DR STRING; 198214.SF4045; -.
DR EnsemblBacteria; AAN45474; AAN45474; SF4045.
DR EnsemblBacteria; AAP18728; AAP18728; S3699.
DR GeneID; 1026937; -.
DR KEGG; sfl:SF4045; -.
DR KEGG; sfx:S3699; -.
DR PATRIC; fig|198214.7.peg.4768; -.
DR HOGENOM; CLU_081861_0_0_6; -.
DR OrthoDB; 1437290at2; -.
DR Proteomes; UP000001006; Chromosome.
DR Proteomes; UP000002673; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006633; P:fatty acid biosynthetic process; IEA:UniProtKB-UniRule.
DR GO; GO:0045717; P:negative regulation of fatty acid biosynthetic process; IEA:UniProtKB-UniRule.
DR HAMAP; MF_01190; HTH_type_FabR; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR001647; HTH_TetR.
DR InterPro; IPR023764; Tscrpt_reg_HTH_FabR.
DR Pfam; PF00440; TetR_N; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR PROSITE; PS50977; HTH_TETR_2; 1.
PE 3: Inferred from homology;
KW Cytoplasm; DNA-binding; Fatty acid biosynthesis; Fatty acid metabolism;
KW Lipid biosynthesis; Lipid metabolism; Reference proteome; Repressor;
KW Transcription; Transcription regulation.
FT CHAIN 1..215
FT /note="HTH-type transcriptional repressor FabR"
FT /id="PRO_0000070642"
FT DOMAIN 10..70
FT /note="HTH tetR-type"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01190"
FT DNA_BIND 33..52
FT /note="H-T-H motif"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01190"
SQ SEQUENCE 215 AA; 24404 MW; ACA9739EA947E256 CRC64;
MGVRAQQKEK TRRSLVEAAF SQLSAERSFA SLSLREVARE AGIAPTSFYR HFRDVDELGL
TMVDESGLML RQLMRQARQR IAKGGSVIRT SVSTFMEFIG NNPNAFRLLL RERSGTSAAF
RAAVAREIQH FIAELADYLE LENHMPRAFT EAQAEAMVTI VFSAGAEALD VGVEQRRQLE
ERLVLQLRMI SKGAYYWYRR EQEKTAIIPG NVKDE
