ID   FABR_YERPA              Reviewed;         211 AA.
AC   Q1CBU4;
DT   10-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT   11-JUL-2006, sequence version 1.
DT   25-MAY-2022, entry version 85.
DE   RecName: Full=HTH-type transcriptional repressor FabR {ECO:0000255|HAMAP-Rule:MF_01190};
GN   Name=fabR {ECO:0000255|HAMAP-Rule:MF_01190}; OrderedLocusNames=YPA_0109;
OS   Yersinia pestis bv. Antiqua (strain Antiqua).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Yersiniaceae; Yersinia.
OX   NCBI_TaxID=360102;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Antiqua;
RX   PubMed=16740952; DOI=10.1128/jb.00124-06;
RA   Chain P.S.G., Hu P., Malfatti S.A., Radnedge L., Larimer F., Vergez L.M.,
RA   Worsham P., Chu M.C., Andersen G.L.;
RT   "Complete genome sequence of Yersinia pestis strains Antiqua and Nepal516:
RT   evidence of gene reduction in an emerging pathogen.";
RL   J. Bacteriol. 188:4453-4463(2006).
CC   -!- FUNCTION: Represses the transcription of fabB, involved in unsaturated
CC       fatty acid (UFA) biosynthesis. By controlling UFA production, FabR
CC       directly influences the physical properties of the membrane bilayer.
CC       {ECO:0000255|HAMAP-Rule:MF_01190}.
CC   -!- SUBUNIT: Homodimer. {ECO:0000255|HAMAP-Rule:MF_01190}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01190}.
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DR   EMBL; CP000308; ABG12078.1; -; Genomic_DNA.
DR   RefSeq; WP_002209476.1; NZ_CP009906.1.
DR   AlphaFoldDB; Q1CBU4; -.
DR   SMR; Q1CBU4; -.
DR   EnsemblBacteria; ABG12078; ABG12078; YPA_0109.
DR   GeneID; 66843485; -.
DR   KEGG; ypa:YPA_0109; -.
DR   OMA; REHWRFI; -.
DR   Proteomes; UP000001971; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006633; P:fatty acid biosynthetic process; IEA:UniProtKB-UniRule.
DR   GO; GO:0045717; P:negative regulation of fatty acid biosynthetic process; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_01190; HTH_type_FabR; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR001647; HTH_TetR.
DR   InterPro; IPR023764; Tscrpt_reg_HTH_FabR.
DR   Pfam; PF00440; TetR_N; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS50977; HTH_TETR_2; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; DNA-binding; Fatty acid biosynthesis; Fatty acid metabolism;
KW   Lipid biosynthesis; Lipid metabolism; Repressor; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..211
FT                   /note="HTH-type transcriptional repressor FabR"
FT                   /id="PRO_0000293580"
FT   DOMAIN          10..70
FT                   /note="HTH tetR-type"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01190"
FT   DNA_BIND        33..52
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01190"
SQ   SEQUENCE   211 AA;  24167 MW;  E70A14DEE10B9304 CRC64;
     MGVRAQQKER TRRSLIEAAF SQLSAERSFA SLSLREVSRE AGIAPTSFYR HFRDVDELGL
     TMVDESGLML RQLMRQARQR IAKGGSVIRT SVSTFMEFIG NNPNAFRLLL RERSGTSAAF
     RAAVAREIQH FIAELADYLE LENHMPRSFT EAQAEAMVTI VFSAGAEVLD VDIEQRRQLE
     ERLVLQLRMI SKGAYYWYRR EQEKLAASRV E