ID   FABR_YERPY              Reviewed;         211 AA.
AC   B1JQ48;
DT   14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT   29-APR-2008, sequence version 1.
DT   25-MAY-2022, entry version 79.
DE   RecName: Full=HTH-type transcriptional repressor FabR {ECO:0000255|HAMAP-Rule:MF_01190};
GN   Name=fabR {ECO:0000255|HAMAP-Rule:MF_01190}; OrderedLocusNames=YPK_4076;
OS   Yersinia pseudotuberculosis serotype O:3 (strain YPIII).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Yersiniaceae; Yersinia.
OX   NCBI_TaxID=502800;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=YPIII;
RG   US DOE Joint Genome Institute;
RA   Copeland A., Lucas S., Lapidus A., Glavina del Rio T., Dalin E., Tice H.,
RA   Bruce D., Goodwin L., Pitluck S., Munk A.C., Brettin T., Detter J.C.,
RA   Han C., Tapia R., Schmutz J., Larimer F., Land M., Hauser L.,
RA   Challacombe J.F., Green L., Lindler L.E., Nikolich M.P., Richardson P.;
RT   "Complete sequence of Yersinia pseudotuberculosis YPIII.";
RL   Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Represses the transcription of fabB, involved in unsaturated
CC       fatty acid (UFA) biosynthesis. By controlling UFA production, FabR
CC       directly influences the physical properties of the membrane bilayer.
CC       {ECO:0000255|HAMAP-Rule:MF_01190}.
CC   -!- SUBUNIT: Homodimer. {ECO:0000255|HAMAP-Rule:MF_01190}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01190}.
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DR   EMBL; CP000950; ACA70335.1; -; Genomic_DNA.
DR   RefSeq; WP_002209476.1; NZ_CP009792.1.
DR   AlphaFoldDB; B1JQ48; -.
DR   SMR; B1JQ48; -.
DR   EnsemblBacteria; ACA70335; ACA70335; YPK_4076.
DR   GeneID; 66843485; -.
DR   KEGG; ypy:YPK_4076; -.
DR   PATRIC; fig|502800.11.peg.425; -.
DR   OMA; REHWRFI; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006633; P:fatty acid biosynthetic process; IEA:UniProtKB-UniRule.
DR   GO; GO:0045717; P:negative regulation of fatty acid biosynthetic process; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_01190; HTH_type_FabR; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR001647; HTH_TetR.
DR   InterPro; IPR023764; Tscrpt_reg_HTH_FabR.
DR   Pfam; PF00440; TetR_N; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS50977; HTH_TETR_2; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; DNA-binding; Fatty acid biosynthesis; Fatty acid metabolism;
KW   Lipid biosynthesis; Lipid metabolism; Repressor; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..211
FT                   /note="HTH-type transcriptional repressor FabR"
FT                   /id="PRO_1000138364"
FT   DOMAIN          10..70
FT                   /note="HTH tetR-type"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01190"
FT   DNA_BIND        33..52
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01190"
SQ   SEQUENCE   211 AA;  24167 MW;  E70A14DEE10B9304 CRC64;
     MGVRAQQKER TRRSLIEAAF SQLSAERSFA SLSLREVSRE AGIAPTSFYR HFRDVDELGL
     TMVDESGLML RQLMRQARQR IAKGGSVIRT SVSTFMEFIG NNPNAFRLLL RERSGTSAAF
     RAAVAREIQH FIAELADYLE LENHMPRSFT EAQAEAMVTI VFSAGAEVLD VDIEQRRQLE
     ERLVLQLRMI SKGAYYWYRR EQEKLAASRV E