ID   AIDAA_XENLA             Reviewed;         305 AA.
AC   Q6PAW0;
DT   02-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 53.
DE   RecName: Full=Axin interactor, dorsalization-associated protein A;
DE   AltName: Full=Axin interaction partner and dorsalization antagonist A;
GN   Name=aida-a;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Kidney;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Acts as a ventralizing factor during embryogenesis. Inhibits
CC       axin-mediated JNK activation by binding axin and disrupting axin
CC       homodimerization. This in turn antagonizes a Wnt/beta-catenin-
CC       independent dorsalization pathway activated by axin/JNK-signaling (By
CC       similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the AIDA family. {ECO:0000255|PROSITE-
CC       ProRule:PRU01259, ECO:0000305}.
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DR   EMBL; BC060024; AAH60024.1; -; mRNA.
DR   RefSeq; NP_001083192.1; NM_001089723.1.
DR   AlphaFoldDB; Q6PAW0; -.
DR   SMR; Q6PAW0; -.
DR   GeneID; 398793; -.
DR   KEGG; xla:398793; -.
DR   CTD; 398793; -.
DR   Xenbase; XB-GENE-6255426; aida.L.
DR   OMA; WSLLQHW; -.
DR   Proteomes; UP000186698; Chromosome 5L.
DR   Bgee; 398793; Expressed in lung and 19 other tissues.
DR   GO; GO:0009953; P:dorsal/ventral pattern formation; ISS:UniProtKB.
DR   GO; GO:0046329; P:negative regulation of JNK cascade; ISS:UniProtKB.
DR   GO; GO:0031333; P:negative regulation of protein-containing complex assembly; ISS:UniProtKB.
DR   Gene3D; 1.20.120.360; -; 1.
DR   Gene3D; 2.60.40.150; -; 1.
DR   InterPro; IPR025939; Aida_C.
DR   InterPro; IPR023421; AIDA_N.
DR   InterPro; IPR036818; AIDA_N_sf.
DR   InterPro; IPR035892; C2_domain_sf.
DR   Pfam; PF14186; Aida_C2; 1.
DR   Pfam; PF08910; Aida_N; 1.
DR   SUPFAM; SSF109779; SSF109779; 1.
DR   PROSITE; PS51911; C2_AIDA; 1.
PE   2: Evidence at transcript level;
KW   Developmental protein; Reference proteome.
FT   CHAIN           1..305
FT                   /note="Axin interactor, dorsalization-associated protein A"
FT                   /id="PRO_0000305282"
FT   DOMAIN          156..303
FT                   /note="C2 Aida-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01259"
FT   REGION          153..220
FT                   /note="Axin-binding"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   305 AA;  34533 MW;  9F3BCAACE2F9EC52 CRC64;
     MSDMNKILHK WSASLKKGTD FDSWGQLVEA IDEYQILARQ LQKEAQSPAN SSDFTEDQKK
     TIGKIATCLG LRSAALQYTQ SQEGFTLEDV KKLEPILSSI VTFNKEFPFD VQPVPLRRIL
     APGEEENLEV DEEEEDGGAG IGSPDLFPAR VPGTLLPRLP SEPGMTLLTI KIEKIGLKDA
     GQCIDPYITV SVKDLNGIDL TPVQDTPMAT RKEDTYVHFN VEIEIQKHVE KLTKGAAIFF
     EFKHYKPKKR FTSTKCFAFM EMDEIKPGQT VIELYKKPTD FKRKKLQLLT KKPLYLHLLQ
     TLLKD