ID   AIDAB_XENLA             Reviewed;         305 AA.
AC   Q6PB19; Q3KQB8;
DT   02-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 54.
DE   RecName: Full=Axin interactor, dorsalization-associated protein B;
DE   AltName: Full=Axin interaction partner and dorsalization antagonist B;
GN   Name=aida-b;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC   TISSUE=Kidney;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Acts as a ventralizing factor during embryogenesis. Inhibits
CC       axin-mediated JNK activation by binding axin and disrupting axin
CC       homodimerization. This in turn antagonizes a Wnt/beta-catenin-
CC       independent dorsalization pathway activated by axin/JNK-signaling (By
CC       similarity). {ECO:0000250}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q6PB19-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q6PB19-2; Sequence=VSP_028324;
CC   -!- SIMILARITY: Belongs to the AIDA family. {ECO:0000255|PROSITE-
CC       ProRule:PRU01259, ECO:0000305}.
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DR   EMBL; BC059964; AAH59964.1; -; mRNA.
DR   EMBL; BC106286; AAI06287.1; -; mRNA.
DR   RefSeq; NP_001083295.1; NM_001089826.1. [Q6PB19-1]
DR   AlphaFoldDB; Q6PB19; -.
DR   SMR; Q6PB19; -.
DR   DNASU; 398850; -.
DR   GeneID; 398850; -.
DR   CTD; 398850; -.
DR   Xenbase; XB-GENE-6255156; aida.S.
DR   Proteomes; UP000186698; Genome assembly.
DR   Bgee; 398850; Expressed in testis and 19 other tissues.
DR   GO; GO:0009953; P:dorsal/ventral pattern formation; ISS:UniProtKB.
DR   GO; GO:0046329; P:negative regulation of JNK cascade; ISS:UniProtKB.
DR   GO; GO:0031333; P:negative regulation of protein-containing complex assembly; ISS:UniProtKB.
DR   Gene3D; 1.20.120.360; -; 1.
DR   Gene3D; 2.60.40.150; -; 1.
DR   InterPro; IPR025939; Aida_C.
DR   InterPro; IPR023421; AIDA_N.
DR   InterPro; IPR036818; AIDA_N_sf.
DR   InterPro; IPR035892; C2_domain_sf.
DR   Pfam; PF14186; Aida_C2; 1.
DR   Pfam; PF08910; Aida_N; 1.
DR   SUPFAM; SSF109779; SSF109779; 1.
DR   PROSITE; PS51911; C2_AIDA; 1.
PE   2: Evidence at transcript level;
KW   Alternative splicing; Developmental protein; Reference proteome.
FT   CHAIN           1..305
FT                   /note="Axin interactor, dorsalization-associated protein B"
FT                   /id="PRO_0000305283"
FT   DOMAIN          156..303
FT                   /note="C2 Aida-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01259"
FT   REGION          126..146
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          153..220
FT                   /note="Axin-binding"
FT                   /evidence="ECO:0000250"
FT   VAR_SEQ         152
FT                   /note="P -> PGAIQ (in isoform 2)"
FT                   /evidence="ECO:0000303|Ref.1"
FT                   /id="VSP_028324"
FT   CONFLICT        100
FT                   /note="I -> V (in Ref. 1; AAI06287)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        141
FT                   /note="A -> V (in Ref. 1; AAI06287)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        266
FT                   /note="R -> K (in Ref. 1; AAI06287)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   305 AA;  34636 MW;  B46E781110D7E315 CRC64;
     MSDMNKILQK WGASLRKGTD FDSWGQLVEA IDEYQILARQ LQKEAQSPAN SSDFTEDQKK
     TIGKIATCLE LRSAALQYTQ SQEGFTLEDV KKLEPILSSI LTFNKEFPFD VQPVPLRRIL
     APGEEENLEV EEEEEDGGAG AGSPDLFPAR VPGTLLPRLP SEPGMTLLTI KIEKIGLKDA
     GQCIDPYITV SVKDLNGIDL TPVQDTPMAV RKEDTYVHFN VEIEIQKHVE KLTKGAAIFF
     EFKHYKPKKR FTSTKCFAFM EMDEIRSGQI VIELYKKPTD FKRKRLQLLT KKPLYLHLLQ
     TLLKD