ID   AIDA_ACIBM              Reviewed;         304 AA.
AC   G2JHL6;
DT   12-SEP-2018, integrated into UniProtKB/Swiss-Prot.
DT   16-NOV-2011, sequence version 1.
DT   03-AUG-2022, entry version 44.
DE   RecName: Full=Quorum-quenching protein AidA {ECO:0000305};
DE   AltName: Full=Quorum-quenching enzyme {ECO:0000303|PubMed:28328989};
DE            Short=QQ enzyme {ECO:0000303|PubMed:28328989};
GN   Name=aidA {ECO:0000303|PubMed:28328989};
GN   ORFNames=ABZJ_02010 {ECO:0000312|EMBL:AEP06470.1};
OS   Acinetobacter baumannii (strain MDR-ZJ06).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Moraxellales; Moraxellaceae;
OC   Acinetobacter; Acinetobacter calcoaceticus/baumannii complex.
OX   NCBI_TaxID=497978;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MDR-ZJ06;
RX   PubMed=21788470; DOI=10.1128/aac.01134-10;
RA   Zhou H., Zhang T., Yu D., Pi B., Yang Q., Zhou J., Hu S., Yu Y.;
RT   "Genomic analysis of the multidrug-resistant Acinetobacter baumannii strain
RT   MDR-ZJ06 widely spread in China.";
RL   Antimicrob. Agents Chemother. 55:4506-4512(2011).
RN   [2]
RP   FUNCTION IN QUORUM QUENCHING, AND INDUCTION.
RC   STRAIN=ST-2_clon_2010;
RX   PubMed=28328989; DOI=10.1371/journal.pone.0174454;
RA   Lopez M., Mayer C., Fernandez-Garcia L., Blasco L., Muras A., Ruiz F.M.,
RA   Bou G., Otero A., Tomas M.;
RT   "Quorum sensing network in clinical strains of A. baumannii: AidA is a new
RT   quorum quenching enzyme.";
RL   PLoS ONE 12:E0174454-E0174454(2017).
CC   -!- FUNCTION: Involved in quorum quenching (QQ). Inhibits motility and
CC       biofilm formation. Could contribute in bacterial competition, as it is
CC       capable of hydrolyzing the signaling molecules that mediate
CC       interspecies communication. {ECO:0000269|PubMed:28328989}.
CC   -!- INDUCTION: Down-regulated in the presence of H(2)O(2).
CC       {ECO:0000269|PubMed:28328989}.
CC   -!- SIMILARITY: Belongs to the AB hydrolase superfamily. {ECO:0000305}.
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DR   EMBL; CP001937; AEP06470.1; -; Genomic_DNA.
DR   RefSeq; WP_000520419.1; NC_017171.2.
DR   AlphaFoldDB; G2JHL6; -.
DR   SMR; G2JHL6; -.
DR   ESTHER; aciba-aida; Xaa-Pro-like_dom.
DR   KEGG; abz:ABZJ_02010; -.
DR   PATRIC; fig|497978.4.peg.1944; -.
DR   HOGENOM; CLU_048587_1_0_6; -.
DR   Proteomes; UP000009290; Chromosome.
DR   GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.1820; -; 1.
DR   InterPro; IPR029058; AB_hydrolase.
DR   InterPro; IPR022742; Hydrolase_4.
DR   Pfam; PF12146; Hydrolase_4; 1.
DR   SUPFAM; SSF53474; SSF53474; 1.
PE   1: Evidence at protein level;
KW   Hydrolase.
FT   CHAIN           1..304
FT                   /note="Quorum-quenching protein AidA"
FT                   /id="PRO_0000445037"
SQ   SEQUENCE   304 AA;  33365 MW;  5332AF2814DFA910 CRC64;
     MGKSLNNVPQ APLDVQFDSN DVKCSAYLYR PTTEVATPMI VMAHGLGGTR RMRLTAFAER
     FVAEGYACLV FDYRYFGDSE GQPRQLLDIK SQLEDWKAAI AYARSLDKID PNRVVIWGTS
     FGGGHVLATA ANDNRLAAVI SQCPFTDGFS SSMAMNPITT LKLMGLALKD KIGSILGAKP
     VMVPLAAPSG HTALMNAPDA YSGYLALMPS GSNIPNYVAA RFVLDIIRYY PGRKTSRIQA
     PVLFCVCDTD SVAPSKTTLR HASHTPNHEI KHYADGHFEI YVGEAFERVV RDQIDFLKRI
     VPVK