ID   AIDA_MACFA              Reviewed;         275 AA.
AC   Q4R8C7;
DT   02-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2005, sequence version 1.
DT   03-AUG-2022, entry version 53.
DE   RecName: Full=Axin interactor, dorsalization-associated protein;
DE   AltName: Full=Axin interaction partner and dorsalization antagonist;
GN   Name=AIDA; ORFNames=QtsA-12796;
OS   Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9541;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RG   International consortium for macaque cDNA sequencing and analysis;
RT   "DNA sequences of macaque genes expressed in brain or testis and its
RT   evolutionary implications.";
RL   Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Acts as a ventralizing factor during embryogenesis. Inhibits
CC       axin-mediated JNK activation by binding axin and disrupting axin
CC       homodimerization. This in turn antagonizes a Wnt/beta-catenin-
CC       independent dorsalization pathway activated by AXIN/JNK-signaling (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with AXIN1. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the AIDA family. {ECO:0000255|PROSITE-
CC       ProRule:PRU01259, ECO:0000305}.
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DR   EMBL; AB168527; BAE00645.1; -; mRNA.
DR   RefSeq; NP_001270111.1; NM_001283182.1.
DR   AlphaFoldDB; Q4R8C7; -.
DR   BMRB; Q4R8C7; -.
DR   SMR; Q4R8C7; -.
DR   STRING; 9541.XP_005540973.1; -.
DR   GeneID; 101925904; -.
DR   CTD; 64853; -.
DR   eggNOG; ENOG502QSD5; Eukaryota.
DR   Proteomes; UP000233100; Unplaced.
DR   GO; GO:0009953; P:dorsal/ventral pattern formation; ISS:UniProtKB.
DR   GO; GO:0046329; P:negative regulation of JNK cascade; ISS:UniProtKB.
DR   GO; GO:0031333; P:negative regulation of protein-containing complex assembly; ISS:UniProtKB.
DR   Gene3D; 1.20.120.360; -; 1.
DR   Gene3D; 2.60.40.150; -; 1.
DR   InterPro; IPR025939; Aida_C.
DR   InterPro; IPR023421; AIDA_N.
DR   InterPro; IPR036818; AIDA_N_sf.
DR   InterPro; IPR035892; C2_domain_sf.
DR   Pfam; PF14186; Aida_C2; 1.
DR   Pfam; PF08910; Aida_N; 1.
DR   SUPFAM; SSF109779; SSF109779; 1.
DR   PROSITE; PS51911; C2_AIDA; 1.
PE   2: Evidence at transcript level;
KW   Developmental protein; Phosphoprotein; Reference proteome.
FT   CHAIN           1..275
FT                   /note="Axin interactor, dorsalization-associated protein"
FT                   /id="PRO_0000305278"
FT   DOMAIN          126..273
FT                   /note="C2 Aida-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01259"
FT   REGION          97..125
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          123..190
FT                   /note="Axin-binding"
FT                   /evidence="ECO:0000250"
FT   MOD_RES         113
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q96BJ3"
SQ   SEQUENCE   275 AA;  31494 MW;  8D28116B68957F86 CRC64;
     MFSSYRLARH LQKEAQAQHN NSEFTEEQKK TIGKIATCLE LRSAALQSTQ SQEEFKLEDL
     KKLEPILKNI LTYNKEFPFD VQPVPLRRIL APGEEENLEF EEDEEEGGAG AGSPDSFPAR
     VPGTLLPRLP SEPGMTLLTI RIEKIGLKDA GQCIDPYITV SVKDLNGIDL TPVQDTPVAS
     RKEDTYVHFN VDIELQKHVE KLTKGAAIFF EFKHYKPKKR FTSTKCFAFM EMDEIKPGPI
     VIELYKKPTD FKRKKLQLLT KKPLYLHLHQ TLHKE