ID   AIDA_PONAB              Reviewed;         306 AA.
AC   Q5RAV3;
DT   02-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT   21-DEC-2004, sequence version 1.
DT   25-MAY-2022, entry version 72.
DE   RecName: Full=Axin interactor, dorsalization-associated protein;
DE   AltName: Full=Axin interaction partner and dorsalization antagonist;
GN   Name=AIDA;
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9601;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Heart;
RG   The German cDNA consortium;
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Acts as a ventralizing factor during embryogenesis. Inhibits
CC       axin-mediated JNK activation by binding axin and disrupting axin
CC       homodimerization. This in turn antagonizes a Wnt/beta-catenin-
CC       independent dorsalization pathway activated by AXIN/JNK-signaling (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with AXIN1. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the AIDA family. {ECO:0000255|PROSITE-
CC       ProRule:PRU01259, ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CR858908; CAH91107.1; -; mRNA.
DR   RefSeq; NP_001125646.1; NM_001132174.1.
DR   AlphaFoldDB; Q5RAV3; -.
DR   BMRB; Q5RAV3; -.
DR   SMR; Q5RAV3; -.
DR   STRING; 9601.ENSPPYP00000000199; -.
DR   Ensembl; ENSPPYT00000000214; ENSPPYP00000000199; ENSPPYG00000000196.
DR   GeneID; 100172565; -.
DR   KEGG; pon:100172565; -.
DR   CTD; 64853; -.
DR   eggNOG; ENOG502QSD5; Eukaryota.
DR   GeneTree; ENSGT00390000016465; -.
DR   HOGENOM; CLU_064322_0_0_1; -.
DR   InParanoid; Q5RAV3; -.
DR   OrthoDB; 1196787at2759; -.
DR   TreeFam; TF328541; -.
DR   Proteomes; UP000001595; Chromosome 1.
DR   GO; GO:0005737; C:cytoplasm; IEA:Ensembl.
DR   GO; GO:0019904; F:protein domain specific binding; IEA:Ensembl.
DR   GO; GO:0009953; P:dorsal/ventral pattern formation; ISS:UniProtKB.
DR   GO; GO:0046329; P:negative regulation of JNK cascade; ISS:UniProtKB.
DR   GO; GO:0043508; P:negative regulation of JUN kinase activity; IEA:Ensembl.
DR   GO; GO:0031333; P:negative regulation of protein-containing complex assembly; ISS:UniProtKB.
DR   Gene3D; 1.20.120.360; -; 1.
DR   Gene3D; 2.60.40.150; -; 1.
DR   InterPro; IPR025939; Aida_C.
DR   InterPro; IPR023421; AIDA_N.
DR   InterPro; IPR036818; AIDA_N_sf.
DR   InterPro; IPR035892; C2_domain_sf.
DR   Pfam; PF14186; Aida_C2; 1.
DR   Pfam; PF08910; Aida_N; 1.
DR   SUPFAM; SSF109779; SSF109779; 1.
DR   PROSITE; PS51911; C2_AIDA; 1.
PE   2: Evidence at transcript level;
KW   Coiled coil; Developmental protein; Phosphoprotein; Reference proteome.
FT   CHAIN           1..306
FT                   /note="Axin interactor, dorsalization-associated protein"
FT                   /id="PRO_0000305280"
FT   DOMAIN          157..304
FT                   /note="C2 Aida-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01259"
FT   REGION          128..153
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          154..221
FT                   /note="Axin-binding"
FT                   /evidence="ECO:0000250"
FT   COILED          27..62
FT                   /evidence="ECO:0000255"
FT   MOD_RES         144
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q96BJ3"
SQ   SEQUENCE   306 AA;  35023 MW;  48E563CEEC398ECC CRC64;
     MSEVTRSLLQ RWGASFRRGA DFDSWGQLVE AIDEYQILAR HLQKEAQAQH NNSEFTEEQK
     KTIGKIATCL ELRSAALQST QSQEEFKLED LKKLEPILKN ILTYNKEFPF DVQPVPLRRI
     LAPGEEENLE FEEDEEEGGA GAGSPDSFPA RVPGTLLPRL PSEPGMTLLT IRIEKIGLKD
     AGQCIDPYIT VSVKDLNGID LTPVQDTPVA SRKEDTYVHF NVDIELQKHV EKLTKGAAIF
     FEFKHYKPKK RFTSTKCFAF MEMDEIKPGP IVIELYKKPT DFKRKKLQLL TKKPLYLHLH
     QTLHKE