ID   FABY_ECO57              Reviewed;         329 AA.
AC   P0ADQ4; P32148;
DT   06-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT   06-DEC-2005, sequence version 1.
DT   03-AUG-2022, entry version 98.
DE   RecName: Full=Probable acyltransferase FabY {ECO:0000250|UniProtKB:P0ADQ2};
DE            EC=2.3.1.- {ECO:0000255|PROSITE-ProRule:PRU00532};
GN   Name=fabY {ECO:0000250|UniProtKB:P0ADQ2}; Synonyms=yiiD;
GN   OrderedLocusNames=Z5427, ECs4811;
OS   Escherichia coli O157:H7.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=83334;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=O157:H7 / EDL933 / ATCC 700927 / EHEC;
RX   PubMed=11206551; DOI=10.1038/35054089;
RA   Perna N.T., Plunkett G. III, Burland V., Mau B., Glasner J.D., Rose D.J.,
RA   Mayhew G.F., Evans P.S., Gregor J., Kirkpatrick H.A., Posfai G.,
RA   Hackett J., Klink S., Boutin A., Shao Y., Miller L., Grotbeck E.J.,
RA   Davis N.W., Lim A., Dimalanta E.T., Potamousis K., Apodaca J.,
RA   Anantharaman T.S., Lin J., Yen G., Schwartz D.C., Welch R.A.,
RA   Blattner F.R.;
RT   "Genome sequence of enterohaemorrhagic Escherichia coli O157:H7.";
RL   Nature 409:529-533(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=O157:H7 / Sakai / RIMD 0509952 / EHEC;
RX   PubMed=11258796; DOI=10.1093/dnares/8.1.11;
RA   Hayashi T., Makino K., Ohnishi M., Kurokawa K., Ishii K., Yokoyama K.,
RA   Han C.-G., Ohtsubo E., Nakayama K., Murata T., Tanaka M., Tobe T., Iida T.,
RA   Takami H., Honda T., Sasakawa C., Ogasawara N., Yasunaga T., Kuhara S.,
RA   Shiba T., Hattori M., Shinagawa H.;
RT   "Complete genome sequence of enterohemorrhagic Escherichia coli O157:H7 and
RT   genomic comparison with a laboratory strain K-12.";
RL   DNA Res. 8:11-22(2001).
CC   -!- FUNCTION: Supports initiation of fatty acid biosynthesis in the absence
CC       of FabH. {ECO:0000250|UniProtKB:P0ADQ2}.
CC   -!- PATHWAY: Lipid metabolism; fatty acid biosynthesis.
CC       {ECO:0000250|UniProtKB:P0ADQ2}.
CC   -!- SIMILARITY: Belongs to the acetyltransferase family. FabY subfamily.
CC       {ECO:0000305}.
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DR   EMBL; AE005174; AAG59078.1; -; Genomic_DNA.
DR   EMBL; BA000007; BAB38234.1; -; Genomic_DNA.
DR   PIR; C91230; C91230.
DR   RefSeq; NP_312838.1; NC_002695.1.
DR   RefSeq; WP_000080791.1; NZ_RICC01000007.1.
DR   AlphaFoldDB; P0ADQ4; -.
DR   SMR; P0ADQ4; -.
DR   STRING; 155864.EDL933_5208; -.
DR   EnsemblBacteria; AAG59078; AAG59078; Z5427.
DR   EnsemblBacteria; BAB38234; BAB38234; ECs_4811.
DR   GeneID; 915092; -.
DR   KEGG; ece:Z5427; -.
DR   KEGG; ecs:ECs_4811; -.
DR   PATRIC; fig|386585.9.peg.5026; -.
DR   eggNOG; COG0456; Bacteria.
DR   HOGENOM; CLU_063776_0_0_6; -.
DR   OMA; SEKDGYD; -.
DR   UniPathway; UPA00094; -.
DR   Proteomes; UP000000558; Chromosome.
DR   Proteomes; UP000002519; Chromosome.
DR   GO; GO:0004343; F:glucosamine 6-phosphate N-acetyltransferase activity; IEA:InterPro.
DR   GO; GO:0006633; P:fatty acid biosynthetic process; IEA:UniProtKB-UniPathway.
DR   GO; GO:0006048; P:UDP-N-acetylglucosamine biosynthetic process; IEA:InterPro.
DR   InterPro; IPR016181; Acyl_CoA_acyltransferase.
DR   InterPro; IPR000182; GNAT_dom.
DR   InterPro; IPR039143; GNPNAT1.
DR   InterPro; IPR029069; HotDog_dom_sf.
DR   InterPro; IPR012660; YiiD_C.
DR   PANTHER; PTHR13355; PTHR13355; 1.
DR   Pfam; PF00583; Acetyltransf_1; 1.
DR   Pfam; PF09500; YiiD_C; 1.
DR   SUPFAM; SSF54637; SSF54637; 1.
DR   SUPFAM; SSF55729; SSF55729; 1.
DR   TIGRFAMs; TIGR02447; yiiD_Cterm; 1.
DR   PROSITE; PS51186; GNAT; 1.
PE   3: Inferred from homology;
KW   Acyltransferase; Lipid metabolism; Reference proteome; Transferase.
FT   CHAIN           1..329
FT                   /note="Probable acyltransferase FabY"
FT                   /id="PRO_0000169680"
FT   DOMAIN          18..162
FT                   /note="N-acetyltransferase"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00532"
SQ   SEQUENCE   329 AA;  37094 MW;  42411FE2B0D21175 CRC64;
     MSQLPGLSRE TRESIAMYHL RVPQTEEELE RYYQFRWEML RKPLHQPKGS ERDAWDAMAH
     HQMVVDEQGN LVAVGRLYIN ADNEASIRFM AVHPDVQDKG LGTLMAMTLE SVARQEGVKR
     VTCSAREDAV EFFAKLGFVN QGEITTPTTT PIRHFLMIKP VATLDDILHR GDWCAQLQQA
     WYEHIPLSEK MGVRIQQYTG QKFITTMPET GNQNPHHTLF AGSLFSLATL TGWGLIWLML
     RERHLGGTII LADAHIRYSK PISGKPHAVA DLGALSGDLD RLARGRKARV QMQVEIFGDE
     TPGAVFEGTY IVLPAKPFGP YEEGGNEEE