ID   FABY_ECOL6              Reviewed;         329 AA.
AC   P0ADQ3; P32148;
DT   06-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT   06-DEC-2005, sequence version 1.
DT   03-AUG-2022, entry version 87.
DE   RecName: Full=Probable acyltransferase FabY {ECO:0000250|UniProtKB:P0ADQ2};
DE            EC=2.3.1.- {ECO:0000255|PROSITE-ProRule:PRU00532};
GN   Name=fabY {ECO:0000250|UniProtKB:P0ADQ2}; Synonyms=yiiD;
GN   OrderedLocusNames=c4835;
OS   Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=199310;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CFT073 / ATCC 700928 / UPEC;
RX   PubMed=12471157; DOI=10.1073/pnas.252529799;
RA   Welch R.A., Burland V., Plunkett G. III, Redford P., Roesch P., Rasko D.,
RA   Buckles E.L., Liou S.-R., Boutin A., Hackett J., Stroud D., Mayhew G.F.,
RA   Rose D.J., Zhou S., Schwartz D.C., Perna N.T., Mobley H.L.T.,
RA   Donnenberg M.S., Blattner F.R.;
RT   "Extensive mosaic structure revealed by the complete genome sequence of
RT   uropathogenic Escherichia coli.";
RL   Proc. Natl. Acad. Sci. U.S.A. 99:17020-17024(2002).
CC   -!- FUNCTION: Supports initiation of fatty acid biosynthesis in the absence
CC       of FabH. {ECO:0000250|UniProtKB:P0ADQ2}.
CC   -!- PATHWAY: Lipid metabolism; fatty acid biosynthesis.
CC       {ECO:0000250|UniProtKB:P0ADQ2}.
CC   -!- SIMILARITY: Belongs to the acetyltransferase family. FabY subfamily.
CC       {ECO:0000305}.
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DR   EMBL; AE014075; AAN83264.1; -; Genomic_DNA.
DR   AlphaFoldDB; P0ADQ3; -.
DR   SMR; P0ADQ3; -.
DR   STRING; 199310.c4835; -.
DR   EnsemblBacteria; AAN83264; AAN83264; c4835.
DR   KEGG; ecc:c4835; -.
DR   eggNOG; COG0456; Bacteria.
DR   HOGENOM; CLU_063776_0_0_6; -.
DR   OMA; SEKDGYD; -.
DR   BioCyc; ECOL199310:C4835-MON; -.
DR   UniPathway; UPA00094; -.
DR   Proteomes; UP000001410; Chromosome.
DR   GO; GO:0004343; F:glucosamine 6-phosphate N-acetyltransferase activity; IEA:InterPro.
DR   GO; GO:0006633; P:fatty acid biosynthetic process; IEA:UniProtKB-UniPathway.
DR   GO; GO:0006048; P:UDP-N-acetylglucosamine biosynthetic process; IEA:InterPro.
DR   InterPro; IPR016181; Acyl_CoA_acyltransferase.
DR   InterPro; IPR000182; GNAT_dom.
DR   InterPro; IPR039143; GNPNAT1.
DR   InterPro; IPR029069; HotDog_dom_sf.
DR   InterPro; IPR012660; YiiD_C.
DR   PANTHER; PTHR13355; PTHR13355; 1.
DR   Pfam; PF00583; Acetyltransf_1; 1.
DR   Pfam; PF09500; YiiD_C; 1.
DR   SUPFAM; SSF54637; SSF54637; 1.
DR   SUPFAM; SSF55729; SSF55729; 1.
DR   TIGRFAMs; TIGR02447; yiiD_Cterm; 1.
DR   PROSITE; PS51186; GNAT; 1.
PE   3: Inferred from homology;
KW   Acyltransferase; Lipid metabolism; Transferase.
FT   CHAIN           1..329
FT                   /note="Probable acyltransferase FabY"
FT                   /id="PRO_0000169681"
FT   DOMAIN          18..162
FT                   /note="N-acetyltransferase"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00532"
SQ   SEQUENCE   329 AA;  37094 MW;  42411FE2B0D21175 CRC64;
     MSQLPGLSRE TRESIAMYHL RVPQTEEELE RYYQFRWEML RKPLHQPKGS ERDAWDAMAH
     HQMVVDEQGN LVAVGRLYIN ADNEASIRFM AVHPDVQDKG LGTLMAMTLE SVARQEGVKR
     VTCSAREDAV EFFAKLGFVN QGEITTPTTT PIRHFLMIKP VATLDDILHR GDWCAQLQQA
     WYEHIPLSEK MGVRIQQYTG QKFITTMPET GNQNPHHTLF AGSLFSLATL TGWGLIWLML
     RERHLGGTII LADAHIRYSK PISGKPHAVA DLGALSGDLD RLARGRKARV QMQVEIFGDE
     TPGAVFEGTY IVLPAKPFGP YEEGGNEEE