ID   FABZ1_LACLA             Reviewed;         151 AA.
AC   Q9CI03;
DT   20-JUN-2001, integrated into UniProtKB/Swiss-Prot.
DT   20-JUN-2001, sequence version 1.
DT   25-MAY-2022, entry version 107.
DE   RecName: Full=3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZ;
DE            EC=4.2.1.59;
DE   AltName: Full=(3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase;
DE            Short=(3R)-hydroxymyristoyl-ACP dehydrase;
DE   AltName: Full=Beta-hydroxyacyl-ACP dehydratase;
GN   Name=fabZ1; OrderedLocusNames=LL0565; ORFNames=L160425;
OS   Lactococcus lactis subsp. lactis (strain IL1403) (Streptococcus lactis).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Lactococcus.
OX   NCBI_TaxID=272623;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=IL1403;
RX   PubMed=11337471; DOI=10.1101/gr.gr-1697r;
RA   Bolotin A., Wincker P., Mauger S., Jaillon O., Malarme K., Weissenbach J.,
RA   Ehrlich S.D., Sorokin A.;
RT   "The complete genome sequence of the lactic acid bacterium Lactococcus
RT   lactis ssp. lactis IL1403.";
RL   Genome Res. 11:731-753(2001).
CC   -!- FUNCTION: Involved in unsaturated fatty acids biosynthesis. Catalyzes
CC       the dehydration of short chain beta-hydroxyacyl-ACPs and long chain
CC       saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity).
CC       {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a (3R)-hydroxyacyl-[ACP] = a (2E)-enoyl-[ACP] + H2O;
CC         Xref=Rhea:RHEA:13097, Rhea:RHEA-COMP:9925, Rhea:RHEA-COMP:9945,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:78784, ChEBI:CHEBI:78827; EC=4.2.1.59;
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the thioester dehydratase family. FabZ
CC       subfamily. {ECO:0000305}.
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DR   EMBL; AE005176; AAK04663.1; -; Genomic_DNA.
DR   PIR; E86695; E86695.
DR   RefSeq; NP_266721.1; NC_002662.1.
DR   RefSeq; WP_003130498.1; NC_002662.1.
DR   AlphaFoldDB; Q9CI03; -.
DR   SMR; Q9CI03; -.
DR   STRING; 272623.L160425; -.
DR   PaxDb; Q9CI03; -.
DR   EnsemblBacteria; AAK04663; AAK04663; L160425.
DR   GeneID; 60356469; -.
DR   GeneID; 66441481; -.
DR   KEGG; lla:L160425; -.
DR   PATRIC; fig|272623.7.peg.603; -.
DR   eggNOG; COG0764; Bacteria.
DR   HOGENOM; CLU_078912_3_0_9; -.
DR   OMA; VMALIPN; -.
DR   Proteomes; UP000002196; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0008659; F:(3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase activity; IEA:UniProtKB-EC.
DR   GO; GO:0008693; F:3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase activity; IEA:UniProtKB-EC.
DR   GO; GO:0047451; F:3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity; IEA:UniProtKB-EC.
DR   GO; GO:0004317; F:3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006633; P:fatty acid biosynthetic process; IEA:UniProtKB-UniRule.
DR   GO; GO:0009245; P:lipid A biosynthetic process; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_00406; FabZ; 1.
DR   InterPro; IPR013114; FabA_FabZ.
DR   InterPro; IPR010084; FabZ.
DR   InterPro; IPR029069; HotDog_dom_sf.
DR   PANTHER; PTHR30272; PTHR30272; 1.
DR   Pfam; PF07977; FabA; 1.
DR   SUPFAM; SSF54637; SSF54637; 1.
DR   TIGRFAMs; TIGR01750; fabZ; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Lipid A biosynthesis; Lipid biosynthesis; Lipid metabolism;
KW   Lyase; Reference proteome.
FT   CHAIN           1..151
FT                   /note="3-hydroxyacyl-[acyl-carrier-protein] dehydratase
FT                   FabZ"
FT                   /id="PRO_0000091691"
FT   ACT_SITE        52
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   151 AA;  16796 MW;  833DBF239A9E638A CRC64;
     MTKKYAMTAT EVMEVIPNRY PIMFIDYVDE ISENKIVATK NVTINEEVFN GHFPGNPTFP
     GVLILESLAQ AGSILILKKE EFQGKMAYIG GIDKAKFRQK VTPGDVMKLE FEITKFRGKV
     GTADAAAYVD GKKVTTCQFT FIVDEAAEQT N