AIF1L_PONAB
ID AIF1L_PONAB Reviewed; 150 AA.
AC Q5RDI4;
DT 07-FEB-2006, integrated into UniProtKB/Swiss-Prot.
DT 21-DEC-2004, sequence version 1.
DT 03-AUG-2022, entry version 83.
DE RecName: Full=Allograft inflammatory factor 1-like;
DE AltName: Full=Ionized calcium-binding adapter molecule 2;
GN Name=AIF1L; Synonyms=IBA2;
OS Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pongo.
OX NCBI_TaxID=9601;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Kidney;
RG The German cDNA consortium;
RL Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Actin-binding protein that promotes actin bundling. May
CC neither bind calcium nor depend on calcium for function (By
CC similarity). {ECO:0000250}.
CC -!- SUBUNIT: Homodimer (Potential). Monomer (By similarity). {ECO:0000250,
CC ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250}. Cell
CC projection, ruffle membrane {ECO:0000250}; Peripheral membrane protein
CC {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Note=Colocalizes with F-
CC actin. Partially relocates to membrane ruffles in response to invading
CC bacteria (By similarity). {ECO:0000250}.
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DR EMBL; CR857925; CAH90173.1; -; mRNA.
DR RefSeq; NP_001125057.1; NM_001131585.1.
DR AlphaFoldDB; Q5RDI4; -.
DR SMR; Q5RDI4; -.
DR GeneID; 100171938; -.
DR KEGG; pon:100171938; -.
DR CTD; 83543; -.
DR InParanoid; Q5RDI4; -.
DR OrthoDB; 1557466at2759; -.
DR Proteomes; UP000001595; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR GO; GO:0032587; C:ruffle membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0051015; F:actin filament binding; ISS:UniProtKB.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR InterPro; IPR028453; Aif1-like.
DR InterPro; IPR042433; AIF1/AIF1L.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR002048; EF_hand_dom.
DR PANTHER; PTHR10356; PTHR10356; 1.
DR PANTHER; PTHR10356:SF5; PTHR10356:SF5; 1.
DR SUPFAM; SSF47473; SSF47473; 1.
DR PROSITE; PS50222; EF_HAND_2; 1.
PE 2: Evidence at transcript level;
KW Acetylation; Actin-binding; Calcium; Cell membrane; Cell projection;
KW Cytoplasm; Cytoskeleton; Membrane; Metal-binding; Phosphoprotein;
KW Reference proteome; Repeat.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000250|UniProtKB:Q9BQI0"
FT CHAIN 2..150
FT /note="Allograft inflammatory factor 1-like"
FT /id="PRO_0000073872"
FT DOMAIN 47..82
FT /note="EF-hand 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT DOMAIN 83..117
FT /note="EF-hand 2; degenerate"
FT /evidence="ECO:0000305"
FT REGION 129..150
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 60
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000305"
FT BINDING 62
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000305"
FT BINDING 64
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000305"
FT BINDING 66
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000305"
FT MOD_RES 2
FT /note="N-acetylserine"
FT /evidence="ECO:0000250|UniProtKB:Q9BQI0"
FT MOD_RES 2
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9BQI0"
FT MOD_RES 134
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9BQI0"
SQ SEQUENCE 150 AA; 17069 MW; 70814E36B9DEBFF6 CRC64;
MSGELSNRFQ GGKAFGLLKA RQERRLAEID REFLCDQKYS DEENLPEKLT AFKEKYMEFD
LNNEGEIDLM SLKRMMEKLG VPKTHLEMKK MISEVTGGVS DTISYRDFVN MMLGKRSAVL
KLVMMFEGKA NESSPKPVGP PPERDIASLP
