ID   FABZ_CAMJJ              Reviewed;         146 AA.
AC   A1VXZ7;
DT   11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT   06-FEB-2007, sequence version 1.
DT   25-MAY-2022, entry version 77.
DE   RecName: Full=3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZ {ECO:0000255|HAMAP-Rule:MF_00406};
DE            EC=4.2.1.59 {ECO:0000255|HAMAP-Rule:MF_00406};
DE   AltName: Full=(3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase {ECO:0000255|HAMAP-Rule:MF_00406};
DE            Short=(3R)-hydroxymyristoyl-ACP dehydrase {ECO:0000255|HAMAP-Rule:MF_00406};
DE   AltName: Full=Beta-hydroxyacyl-ACP dehydratase {ECO:0000255|HAMAP-Rule:MF_00406};
GN   Name=fabZ {ECO:0000255|HAMAP-Rule:MF_00406};
GN   OrderedLocusNames=CJJ81176_0300;
OS   Campylobacter jejuni subsp. jejuni serotype O:23/36 (strain 81-176).
OC   Bacteria; Proteobacteria; Epsilonproteobacteria; Campylobacterales;
OC   Campylobacteraceae; Campylobacter.
OX   NCBI_TaxID=354242;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=81-176;
RA   Fouts D.E., Nelson K.E., Sebastian Y.;
RL   Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Involved in unsaturated fatty acids biosynthesis. Catalyzes
CC       the dehydration of short chain beta-hydroxyacyl-ACPs and long chain
CC       saturated and unsaturated beta-hydroxyacyl-ACPs. {ECO:0000255|HAMAP-
CC       Rule:MF_00406}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a (3R)-hydroxyacyl-[ACP] = a (2E)-enoyl-[ACP] + H2O;
CC         Xref=Rhea:RHEA:13097, Rhea:RHEA-COMP:9925, Rhea:RHEA-COMP:9945,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:78784, ChEBI:CHEBI:78827; EC=4.2.1.59;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_00406};
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00406}.
CC   -!- SIMILARITY: Belongs to the thioester dehydratase family. FabZ
CC       subfamily. {ECO:0000255|HAMAP-Rule:MF_00406}.
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DR   EMBL; CP000538; EAQ73095.1; -; Genomic_DNA.
DR   RefSeq; WP_002857452.1; NC_008787.1.
DR   PDB; 3D6X; X-ray; 2.59 A; A/B/C/D/E/F=1-146.
DR   PDBsum; 3D6X; -.
DR   AlphaFoldDB; A1VXZ7; -.
DR   SMR; A1VXZ7; -.
DR   STRING; 354242.CJJ81176_0300; -.
DR   EnsemblBacteria; EAQ73095; EAQ73095; CJJ81176_0300.
DR   KEGG; cjj:CJJ81176_0300; -.
DR   eggNOG; COG0764; Bacteria.
DR   HOGENOM; CLU_078912_1_2_7; -.
DR   OMA; FPGRPLM; -.
DR   EvolutionaryTrace; A1VXZ7; -.
DR   Proteomes; UP000000646; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0008659; F:(3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase activity; IEA:UniProtKB-EC.
DR   GO; GO:0008693; F:3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase activity; IEA:UniProtKB-EC.
DR   GO; GO:0047451; F:3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity; IEA:UniProtKB-EC.
DR   GO; GO:0004317; F:3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006633; P:fatty acid biosynthetic process; IEA:UniProtKB-UniRule.
DR   GO; GO:0009245; P:lipid A biosynthetic process; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_00406; FabZ; 1.
DR   InterPro; IPR013114; FabA_FabZ.
DR   InterPro; IPR010084; FabZ.
DR   InterPro; IPR029069; HotDog_dom_sf.
DR   PANTHER; PTHR30272; PTHR30272; 1.
DR   Pfam; PF07977; FabA; 1.
DR   SUPFAM; SSF54637; SSF54637; 1.
DR   TIGRFAMs; TIGR01750; fabZ; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Cytoplasm; Lipid A biosynthesis; Lipid biosynthesis;
KW   Lipid metabolism; Lyase.
FT   CHAIN           1..146
FT                   /note="3-hydroxyacyl-[acyl-carrier-protein] dehydratase
FT                   FabZ"
FT                   /id="PRO_0000301885"
FT   ACT_SITE        48
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00406"
FT   HELIX           4..10
FT                   /evidence="ECO:0007829|PDB:3D6X"
FT   STRAND          22..27
FT                   /evidence="ECO:0007829|PDB:3D6X"
FT   TURN            28..30
FT                   /evidence="ECO:0007829|PDB:3D6X"
FT   STRAND          31..37
FT                   /evidence="ECO:0007829|PDB:3D6X"
FT   HELIX           44..47
FT                   /evidence="ECO:0007829|PDB:3D6X"
FT   HELIX           57..73
FT                   /evidence="ECO:0007829|PDB:3D6X"
FT   STRAND          87..97
FT                   /evidence="ECO:0007829|PDB:3D6X"
FT   STRAND          106..117
FT                   /evidence="ECO:0007829|PDB:3D6X"
FT   STRAND          120..129
FT                   /evidence="ECO:0007829|PDB:3D6X"
FT   STRAND          132..143
FT                   /evidence="ECO:0007829|PDB:3D6X"
SQ   SEQUENCE   146 AA;  16440 MW;  EFFA2656B12563A5 CRC64;
     MIDVMQIQEI LPHRYPFLLV DKITELKVKE VVLGYKNISI SDHVFMGHFP GHPIYPGVLI
     LEGMAQTGGV LAFESMEDKV DPKSKVVYFT GIDGAKFRNP VRPGDRLDYE MSVVKNRGNM
     WIFKGQAFVD GNLVAEAELK AMIVDK