ID   AIFA_DICDI              Reviewed;         408 AA.
AC   Q54NS9;
DT   29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   24-MAY-2005, sequence version 1.
DT   03-AUG-2022, entry version 103.
DE   RecName: Full=Apoptosis-inducing factor homolog A;
DE            EC=1.-.-.-;
GN   Name=aifA; ORFNames=DDB_G0285003;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- FUNCTION: Putative FAD-dependent oxidoreductase. {ECO:0000250}.
CC   -!- COFACTOR:
CC       Name=FAD; Xref=ChEBI:CHEBI:57692; Evidence={ECO:0000250};
CC   -!- SIMILARITY: Belongs to the FAD-dependent oxidoreductase family.
CC       {ECO:0000305}.
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DR   EMBL; AAFI02000073; EAL64965.1; -; Genomic_DNA.
DR   RefSeq; XP_639988.1; XM_634896.1.
DR   AlphaFoldDB; Q54NS9; -.
DR   SMR; Q54NS9; -.
DR   STRING; 44689.DDB0266658; -.
DR   PaxDb; Q54NS9; -.
DR   EnsemblProtists; EAL64965; EAL64965; DDB_G0285003.
DR   GeneID; 8624902; -.
DR   KEGG; ddi:DDB_G0285003; -.
DR   dictyBase; DDB_G0285003; aifC.
DR   eggNOG; KOG2495; Eukaryota.
DR   HOGENOM; CLU_019845_2_0_1; -.
DR   InParanoid; Q54NS9; -.
DR   OMA; GDSFRQG; -.
DR   PhylomeDB; Q54NS9; -.
DR   PRO; PR:Q54NS9; -.
DR   Proteomes; UP000002195; Chromosome 4.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0005811; C:lipid droplet; HDA:dictyBase.
DR   GO; GO:0004174; F:electron-transferring-flavoprotein dehydrogenase activity; IBA:GO_Central.
DR   GO; GO:0050660; F:flavin adenine dinucleotide binding; IBA:GO_Central.
DR   InterPro; IPR036188; FAD/NAD-bd_sf.
DR   InterPro; IPR023753; FAD/NAD-binding_dom.
DR   Pfam; PF07992; Pyr_redox_2; 1.
DR   SUPFAM; SSF51905; SSF51905; 2.
PE   3: Inferred from homology;
KW   FAD; Flavoprotein; Oxidoreductase; Reference proteome.
FT   CHAIN           1..408
FT                   /note="Apoptosis-inducing factor homolog A"
FT                   /id="PRO_0000331383"
FT   BINDING         34..38
FT                   /ligand="FAD"
FT                   /ligand_id="ChEBI:CHEBI:57692"
FT                   /evidence="ECO:0000255"
FT   BINDING         69
FT                   /ligand="FAD"
FT                   /ligand_id="ChEBI:CHEBI:57692"
FT                   /evidence="ECO:0000255"
FT   BINDING         314
FT                   /ligand="FAD"
FT                   /ligand_id="ChEBI:CHEBI:57692"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   408 AA;  45761 MW;  EFD0FEFE47740C66 CRC64;
     MNYLYNISES LKKIFNYFSS ITRDCEKKRV LIIGCGFGGS QVAKLLDSNF EVTVVERKQT
     FFNSIASIRA IVEPELAKKI YIPYDKLLKN GKFIYGTVIE ISPTLVKLED GKELTFDYLV
     IATGSNSLAP FKAPLEKISG TEIFNYYKDI SEQIKQAKSI LIVGGGSVGC EVVGEIINKY
     PIKNKELAKK ITIVHSGNKL VSSKTNNKFN NLINESMKKR NVSVILNDRI EIPDDIKQCF
     INQTSPNFQV SLKTYKTKNG LSIESDFVIW TIGIKLNSES YKTNFSNEIN EIGQIKVNQS
     CQVQGYDNIF AIGDITDFDE LKTTYNALSH GNIVAKVIKD LSNGKNKNQL AKHKLLPPII
     SLSLGPKDGL TQINSNLNFG SFISRILKSN NLLINRFQTH FNNPEPLK