FABZ_NEIMF
ID FABZ_NEIMF Reviewed; 149 AA.
AC A1KRL1;
DT 11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT 06-FEB-2007, sequence version 1.
DT 25-MAY-2022, entry version 77.
DE RecName: Full=3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZ {ECO:0000255|HAMAP-Rule:MF_00406};
DE EC=4.2.1.59 {ECO:0000255|HAMAP-Rule:MF_00406};
DE AltName: Full=(3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase {ECO:0000255|HAMAP-Rule:MF_00406};
DE Short=(3R)-hydroxymyristoyl-ACP dehydrase {ECO:0000255|HAMAP-Rule:MF_00406};
DE AltName: Full=Beta-hydroxyacyl-ACP dehydratase {ECO:0000255|HAMAP-Rule:MF_00406};
GN Name=fabZ {ECO:0000255|HAMAP-Rule:MF_00406}; OrderedLocusNames=NMC0170;
OS Neisseria meningitidis serogroup C / serotype 2a (strain ATCC 700532 / DSM
OS 15464 / FAM18).
OC Bacteria; Proteobacteria; Betaproteobacteria; Neisseriales; Neisseriaceae;
OC Neisseria.
OX NCBI_TaxID=272831;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 700532 / DSM 15464 / FAM18;
RX PubMed=17305430; DOI=10.1371/journal.pgen.0030023;
RA Bentley S.D., Vernikos G.S., Snyder L.A.S., Churcher C., Arrowsmith C.,
RA Chillingworth T., Cronin A., Davis P.H., Holroyd N.E., Jagels K.,
RA Maddison M., Moule S., Rabbinowitsch E., Sharp S., Unwin L., Whitehead S.,
RA Quail M.A., Achtman M., Barrell B.G., Saunders N.J., Parkhill J.;
RT "Meningococcal genetic variation mechanisms viewed through comparative
RT analysis of serogroup C strain FAM18.";
RL PLoS Genet. 3:230-240(2007).
CC -!- FUNCTION: Involved in unsaturated fatty acids biosynthesis. Catalyzes
CC the dehydration of short chain beta-hydroxyacyl-ACPs and long chain
CC saturated and unsaturated beta-hydroxyacyl-ACPs. {ECO:0000255|HAMAP-
CC Rule:MF_00406}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a (3R)-hydroxyacyl-[ACP] = a (2E)-enoyl-[ACP] + H2O;
CC Xref=Rhea:RHEA:13097, Rhea:RHEA-COMP:9925, Rhea:RHEA-COMP:9945,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:78784, ChEBI:CHEBI:78827; EC=4.2.1.59;
CC Evidence={ECO:0000255|HAMAP-Rule:MF_00406};
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00406}.
CC -!- SIMILARITY: Belongs to the thioester dehydratase family. FabZ
CC subfamily. {ECO:0000255|HAMAP-Rule:MF_00406}.
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DR EMBL; AM421808; CAM09489.1; -; Genomic_DNA.
DR RefSeq; WP_002216259.1; NC_008767.1.
DR PDB; 4I83; X-ray; 2.60 A; A/B/C/D/E/F=1-149.
DR PDBsum; 4I83; -.
DR AlphaFoldDB; A1KRL1; -.
DR SMR; A1KRL1; -.
DR EnsemblBacteria; CAM09489; CAM09489; NMC0170.
DR KEGG; nmc:NMC0170; -.
DR HOGENOM; CLU_078912_1_0_4; -.
DR OMA; FPGRPLM; -.
DR OrthoDB; 1763197at2; -.
DR Proteomes; UP000002286; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0008659; F:(3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase activity; IEA:UniProtKB-EC.
DR GO; GO:0008693; F:3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase activity; IEA:UniProtKB-EC.
DR GO; GO:0047451; F:3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity; IEA:UniProtKB-EC.
DR GO; GO:0004317; F:3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase activity; IEA:UniProtKB-EC.
DR GO; GO:0006633; P:fatty acid biosynthetic process; IEA:UniProtKB-UniRule.
DR GO; GO:0009245; P:lipid A biosynthetic process; IEA:UniProtKB-UniRule.
DR HAMAP; MF_00406; FabZ; 1.
DR InterPro; IPR013114; FabA_FabZ.
DR InterPro; IPR010084; FabZ.
DR InterPro; IPR029069; HotDog_dom_sf.
DR PANTHER; PTHR30272; PTHR30272; 1.
DR Pfam; PF07977; FabA; 1.
DR SUPFAM; SSF54637; SSF54637; 1.
DR TIGRFAMs; TIGR01750; fabZ; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Cytoplasm; Lipid A biosynthesis; Lipid biosynthesis;
KW Lipid metabolism; Lyase.
FT CHAIN 1..149
FT /note="3-hydroxyacyl-[acyl-carrier-protein] dehydratase
FT FabZ"
FT /id="PRO_0000301905"
FT ACT_SITE 53
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00406"
FT STRAND 5..8
FT /evidence="ECO:0007829|PDB:4I83"
FT HELIX 9..15
FT /evidence="ECO:0007829|PDB:4I83"
FT STRAND 27..32
FT /evidence="ECO:0007829|PDB:4I83"
FT TURN 33..35
FT /evidence="ECO:0007829|PDB:4I83"
FT STRAND 36..42
FT /evidence="ECO:0007829|PDB:4I83"
FT STRAND 45..47
FT /evidence="ECO:0007829|PDB:4I83"
FT HELIX 48..51
FT /evidence="ECO:0007829|PDB:4I83"
FT HELIX 62..80
FT /evidence="ECO:0007829|PDB:4I83"
FT TURN 85..87
FT /evidence="ECO:0007829|PDB:4I83"
FT STRAND 91..95
FT /evidence="ECO:0007829|PDB:4I83"
FT STRAND 97..100
FT /evidence="ECO:0007829|PDB:4I83"
FT STRAND 109..120
FT /evidence="ECO:0007829|PDB:4I83"
FT STRAND 123..132
FT /evidence="ECO:0007829|PDB:4I83"
FT STRAND 135..145
FT /evidence="ECO:0007829|PDB:4I83"
SQ SEQUENCE 149 AA; 16613 MW; DE6BCB39FB8DACBE CRC64;
MDVQLPIEAK DIQKLIPHRY PFLQLDRITA FEPMKTLTAI KNVSINEPQF QGHFPDLPVM
PGVLIIEAMA QACGTLAILS EGGRKENEFF FFAGIDEARF KRQVIPGDQL VFEVELLTSR
RGIGKFNAVA KVDGQVAVEA IIMCAKRVV
