ID   FABZ_SALTY              Reviewed;         151 AA.
AC   P0A1H9; P21773;
DT   01-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2005, sequence version 1.
DT   03-AUG-2022, entry version 90.
DE   RecName: Full=3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZ;
DE            EC=4.2.1.59;
DE   AltName: Full=(3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase;
DE            Short=(3R)-hydroxymyristoyl-ACP dehydrase;
DE   AltName: Full=Beta-hydroxyacyl-ACP dehydratase;
GN   Name=fabZ; OrderedLocusNames=STM0227;
OS   Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Salmonella.
OX   NCBI_TaxID=99287;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=LT2 / SGSC1412 / ATCC 700720;
RX   PubMed=11677609; DOI=10.1038/35101614;
RA   McClelland M., Sanderson K.E., Spieth J., Clifton S.W., Latreille P.,
RA   Courtney L., Porwollik S., Ali J., Dante M., Du F., Hou S., Layman D.,
RA   Leonard S., Nguyen C., Scott K., Holmes A., Grewal N., Mulvaney E.,
RA   Ryan E., Sun H., Florea L., Miller W., Stoneking T., Nhan M., Waterston R.,
RA   Wilson R.K.;
RT   "Complete genome sequence of Salmonella enterica serovar Typhimurium LT2.";
RL   Nature 413:852-856(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-134.
RX   PubMed=2256935; DOI=10.1016/s0006-291x(05)81020-4;
RA   Hirvas L., Koski P., Vaara M.;
RT   "Primary structure and expression of the Ssc-protein of Salmonella
RT   typhimurium.";
RL   Biochem. Biophys. Res. Commun. 173:53-59(1990).
RN   [3]
RP   ERRATUM OF PUBMED:2256935.
RA   Hirvas L., Koski P., Vaara M.;
RL   Biochem. Biophys. Res. Commun. 174:1054-1054(1991).
CC   -!- FUNCTION: Involved in unsaturated fatty acids biosynthesis. Catalyzes
CC       the dehydration of short chain beta-hydroxyacyl-ACPs and long chain
CC       saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity).
CC       {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a (3R)-hydroxyacyl-[ACP] = a (2E)-enoyl-[ACP] + H2O;
CC         Xref=Rhea:RHEA:13097, Rhea:RHEA-COMP:9925, Rhea:RHEA-COMP:9945,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:78784, ChEBI:CHEBI:78827; EC=4.2.1.59;
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the thioester dehydratase family. FabZ
CC       subfamily. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AE006468; AAL19191.1; -; Genomic_DNA.
DR   EMBL; M35193; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   PIR; C37083; C37083.
DR   RefSeq; NP_459232.1; NC_003197.2.
DR   RefSeq; WP_000210741.1; NC_003197.2.
DR   AlphaFoldDB; P0A1H9; -.
DR   SMR; P0A1H9; -.
DR   STRING; 99287.STM0227; -.
DR   PaxDb; P0A1H9; -.
DR   EnsemblBacteria; AAL19191; AAL19191; STM0227.
DR   GeneID; 1251745; -.
DR   GeneID; 66754751; -.
DR   KEGG; stm:STM0227; -.
DR   PATRIC; fig|99287.12.peg.240; -.
DR   HOGENOM; CLU_078912_1_0_6; -.
DR   OMA; FPGRPLM; -.
DR   PhylomeDB; P0A1H9; -.
DR   BioCyc; SENT99287:STM0227-MON; -.
DR   Proteomes; UP000001014; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0008659; F:(3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase activity; IEA:UniProtKB-EC.
DR   GO; GO:0008693; F:3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase activity; IEA:UniProtKB-EC.
DR   GO; GO:0047451; F:3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity; IEA:UniProtKB-EC.
DR   GO; GO:0004317; F:3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006633; P:fatty acid biosynthetic process; IEA:UniProtKB-UniRule.
DR   GO; GO:0009245; P:lipid A biosynthetic process; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_00406; FabZ; 1.
DR   InterPro; IPR013114; FabA_FabZ.
DR   InterPro; IPR010084; FabZ.
DR   InterPro; IPR029069; HotDog_dom_sf.
DR   PANTHER; PTHR30272; PTHR30272; 1.
DR   Pfam; PF07977; FabA; 1.
DR   SUPFAM; SSF54637; SSF54637; 1.
DR   TIGRFAMs; TIGR01750; fabZ; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Lipid A biosynthesis; Lipid biosynthesis; Lipid metabolism;
KW   Lyase; Reference proteome.
FT   CHAIN           1..151
FT                   /note="3-hydroxyacyl-[acyl-carrier-protein] dehydratase
FT                   FabZ"
FT                   /id="PRO_0000091726"
FT   ACT_SITE        54
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   151 AA;  16999 MW;  71151E0D3B3C85BB CRC64;
     MTTNTHTLQI EEILELLPHR FPFLLVDRVL DFEEGRFLRA VKNVSVNEPF FQGHFPGKPI
     LPGVLILEAM AQATGILAFK SVGKLEPGEL YYFAGIDEAR FKRPVVPGDQ MIMEVTFEKT
     RRGLTRFKGV ALVDGKVVCE ATMMCARSRE A