ID   AIM11_YEAST             Reviewed;         137 AA.
AC   P87275; D3DM01;
DT   25-OCT-2005, integrated into UniProtKB/Swiss-Prot.
DT   25-OCT-2005, sequence version 2.
DT   03-AUG-2022, entry version 114.
DE   RecName: Full=Altered inheritance of mitochondria protein 11;
DE   AltName: Full=Genetic interactor of prohibitins 8;
GN   Name=AIM11; Synonyms=GEP8; OrderedLocusNames=YER093C-A;
OS   Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX   NCBI_TaxID=559292;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=9169868;
RA   Dietrich F.S., Mulligan J.T., Hennessy K.M., Yelton M.A., Allen E.,
RA   Araujo R., Aviles E., Berno A., Brennan T., Carpenter J., Chen E.,
RA   Cherry J.M., Chung E., Duncan M., Guzman E., Hartzell G., Hunicke-Smith S.,
RA   Hyman R.W., Kayser A., Komp C., Lashkari D., Lew H., Lin D., Mosedale D.,
RA   Nakahara K., Namath A., Norgren R., Oefner P., Oh C., Petel F.X.,
RA   Roberts D., Sehl P., Schramm S., Shogren T., Smith V., Taylor P., Wei Y.,
RA   Botstein D., Davis R.W.;
RT   "The nucleotide sequence of Saccharomyces cerevisiae chromosome V.";
RL   Nature 387:78-81(1997).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=24374639; DOI=10.1534/g3.113.008995;
RA   Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA   Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA   Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT   "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL   G3 (Bethesda) 4:389-398(2014).
RN   [3]
RP   LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
RX   PubMed=14562106; DOI=10.1038/nature02046;
RA   Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N.,
RA   O'Shea E.K., Weissman J.S.;
RT   "Global analysis of protein expression in yeast.";
RL   Nature 425:737-741(2003).
RN   [4]
RP   DISRUPTION PHENOTYPE.
RX   PubMed=19221197; DOI=10.1083/jcb.200810189;
RA   Osman C., Haag M., Potting C., Rodenfels J., Dip P.V., Wieland F.T.,
RA   Brugger B., Westermann B., Langer T.;
RT   "The genetic interactome of prohibitins: coordinated control of cardiolipin
RT   and phosphatidylethanolamine by conserved regulators in mitochondria.";
RL   J. Cell Biol. 184:583-596(2009).
RN   [5]
RP   DISRUPTION PHENOTYPE.
RX   PubMed=19300474; DOI=10.1371/journal.pgen.1000407;
RA   Hess D.C., Myers C.L., Huttenhower C., Hibbs M.A., Hayes A.P., Paw J.,
RA   Clore J.J., Mendoza R.M., Luis B.S., Nislow C., Giaever G., Costanzo M.,
RA   Troyanskaya O.G., Caudy A.A.;
RT   "Computationally driven, quantitative experiments discover genes required
RT   for mitochondrial biogenesis.";
RL   PLoS Genet. 5:E1000407-E1000407(2009).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- DISRUPTION PHENOTYPE: Increases frequency of mitochondrial genome loss
CC       and leads to synthetic letality with a prohibitin complex subunit PHB1
CC       deletant. {ECO:0000269|PubMed:19221197, ECO:0000269|PubMed:19300474}.
CC   -!- MISCELLANEOUS: Present with 1835 molecules/cell in log phase SD medium.
CC       {ECO:0000269|PubMed:14562106}.
CC   -!- SIMILARITY: Belongs to the AIM11 family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAB64664.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR   EMBL; U18839; AAB64664.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; BK006939; DAA07755.1; -; Genomic_DNA.
DR   PIR; S53547; S53547.
DR   RefSeq; NP_011019.1; NM_001180860.1.
DR   AlphaFoldDB; P87275; -.
DR   SMR; P87275; -.
DR   BioGRID; 36839; 324.
DR   STRING; 4932.YER093C-A; -.
DR   MaxQB; P87275; -.
DR   PaxDb; P87275; -.
DR   PRIDE; P87275; -.
DR   EnsemblFungi; YER093C-A_mRNA; YER093C-A; YER093C-A.
DR   GeneID; 856829; -.
DR   KEGG; sce:YER093C-A; -.
DR   SGD; S000002960; AIM11.
DR   VEuPathDB; FungiDB:YER093C-A; -.
DR   eggNOG; ENOG502SAK0; Eukaryota.
DR   GeneTree; ENSGT00940000176820; -.
DR   HOGENOM; CLU_118700_0_0_1; -.
DR   InParanoid; P87275; -.
DR   OMA; FGWKMKS; -.
DR   BioCyc; YEAST:G3O-30355-MON; -.
DR   PRO; PR:P87275; -.
DR   Proteomes; UP000002311; Chromosome V.
DR   RNAct; P87275; protein.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005739; C:mitochondrion; HDA:SGD.
DR   InterPro; IPR038814; AIM11.
DR   PANTHER; PTHR39136; PTHR39136; 1.
PE   1: Evidence at protein level;
KW   Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..137
FT                   /note="Altered inheritance of mitochondria protein 11"
FT                   /id="PRO_0000202641"
FT   TRANSMEM        20..37
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        66..88
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   137 AA;  15753 MW;  64B4F23FCE4C94A9 CRC64;
     MIEEKKELKK RRVLQMARFY GAAAFTLITM RLISRAIKVR KYVPSIFQQN YKLPPFSQRN
     EAMSALTYAS AASIGTFSTL IFGFCWALDI STAREFVFKT REFMSLPQAL ETDTSMDEET
     SKLTKQLQDL LSSENNK