FACC1_MOUSE
ID FACC1_MOUSE Reviewed; 383 AA.
AC Q8BVM7;
DT 22-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 114.
DE RecName: Full=Flagellum-associated coiled-coil domain-containing protein 1 {ECO:0000250|UniProtKB:Q96Q35};
DE AltName: Full=Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 12 protein homolog;
GN Name=Flacc1 {ECO:0000250|UniProtKB:Q96Q35};
GN Synonyms=Als2cr12 {ECO:0000312|MGI:MGI:1918359};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J {ECO:0000312|EMBL:BAC36671.1};
RC TISSUE=Testis {ECO:0000312|EMBL:AK016678, ECO:0000312|EMBL:BAC36671.1};
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP IDENTIFICATION (ISOFORMS 1 AND 2), SUBCELLULAR LOCATION, AND TISSUE
RP SPECIFICITY.
RX PubMed=21402173; DOI=10.1016/j.gep.2011.03.003;
RA Choi E., Cho C.;
RT "Expression of a sperm flagellum component encoded by the Als2cr12 gene.";
RL Gene Expr. Patterns 11:327-333(2011).
CC -!- SUBCELLULAR LOCATION: [Isoform 1]: Cytoplasm
CC {ECO:0000269|PubMed:21402173}. Cytoplasmic granule
CC {ECO:0000269|PubMed:21402173}. Cell projection, cilium, flagellum
CC {ECO:0000269|PubMed:21402173}. Note=Expressed in the principal piece of
CC the sperm tail, nearest the sperm head. {ECO:0000269|PubMed:21402173}.
CC -!- SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm
CC {ECO:0000269|PubMed:21402173}. Cytoplasmic granule
CC {ECO:0000269|PubMed:21402173}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1; Synonyms=L {ECO:0000303|PubMed:21402173};
CC IsoId=Q8BVM7-1; Sequence=Displayed;
CC Name=2; Synonyms=S {ECO:0000303|PubMed:21402173};
CC IsoId=Q8BVM7-2; Sequence=VSP_058875, VSP_058876;
CC -!- TISSUE SPECIFICITY: Isoform 1 is specific to germ cells of the testis
CC and localizes to the principal piece of the sperm flagellum. Isoform 2
CC seems to be expressed mainly in somatic cells of the testis, and is not
CC detected in mature spermatozoa (at protein level). Isoform 2 may also
CC be expressed weakly in brain. {ECO:0000269|PubMed:21402173}.
CC -!- MISCELLANEOUS: [Isoform 2]: May be due to intron retention.
CC {ECO:0000305}.
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DR EMBL; AK016678; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; AK077190; BAC36671.1; -; mRNA.
DR CCDS; CCDS35581.1; -. [Q8BVM7-1]
DR RefSeq; NP_780579.1; NM_175370.5. [Q8BVM7-1]
DR AlphaFoldDB; Q8BVM7; -.
DR SMR; Q8BVM7; -.
DR BioGRID; 224431; 1.
DR STRING; 10090.ENSMUSP00000062497; -.
DR iPTMnet; Q8BVM7; -.
DR PhosphoSitePlus; Q8BVM7; -.
DR PaxDb; Q8BVM7; -.
DR PRIDE; Q8BVM7; -.
DR ProteomicsDB; 285807; -. [Q8BVM7-1]
DR ProteomicsDB; 285808; -. [Q8BVM7-2]
DR Antibodypedia; 34140; 86 antibodies from 20 providers.
DR DNASU; 108812; -.
DR Ensembl; ENSMUST00000055313; ENSMUSP00000062497; ENSMUSG00000047528. [Q8BVM7-1]
DR GeneID; 108812; -.
DR KEGG; mmu:108812; -.
DR UCSC; uc007bcm.2; mouse. [Q8BVM7-1]
DR CTD; 130540; -.
DR MGI; MGI:1918359; Flacc1.
DR VEuPathDB; HostDB:ENSMUSG00000047528; -.
DR eggNOG; ENOG502R2KT; Eukaryota.
DR GeneTree; ENSGT00400000022323; -.
DR HOGENOM; CLU_049696_0_0_1; -.
DR InParanoid; Q8BVM7; -.
DR PhylomeDB; Q8BVM7; -.
DR TreeFam; TF338239; -.
DR BioGRID-ORCS; 108812; 1 hit in 71 CRISPR screens.
DR ChiTaRS; Flacc1; mouse.
DR PRO; PR:Q8BVM7; -.
DR Proteomes; UP000000589; Chromosome 1.
DR RNAct; Q8BVM7; protein.
DR Bgee; ENSMUSG00000047528; Expressed in spermatocyte and 48 other tissues.
DR ExpressionAtlas; Q8BVM7; baseline and differential.
DR Genevisible; Q8BVM7; MM.
DR GO; GO:0005737; C:cytoplasm; IDA:UniProtKB.
DR GO; GO:0031410; C:cytoplasmic vesicle; IDA:UniProtKB.
DR GO; GO:0001520; C:outer dense fiber; IDA:UniProtKB.
DR GO; GO:0035686; C:sperm fibrous sheath; IBA:GO_Central.
DR GO; GO:0036126; C:sperm flagellum; IDA:UniProtKB.
DR InterPro; IPR026674; FLACC1.
DR PANTHER; PTHR21707; PTHR21707; 1.
PE 1: Evidence at protein level;
KW Acetylation; Alternative splicing; Cell projection; Cilium; Coiled coil;
KW Cytoplasm; Flagellum; Reference proteome.
FT CHAIN 1..383
FT /note="Flagellum-associated coiled-coil domain-containing
FT protein 1"
FT /id="PRO_0000344494"
FT REGION 26..79
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 125..220
FT /evidence="ECO:0000255"
FT COILED 276..359
FT /evidence="ECO:0000255"
FT COMPBIAS 48..79
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 354
FT /note="N6-acetyllysine"
FT /evidence="ECO:0000250|UniProtKB:Q96Q35"
FT VAR_SEQ 209..245
FT /note="DKMSKEYKYLKSMFHVFQDSIYEEMEDKWLRRKAEWE -> GTVGPWGDAGR
FT KVDSLPWHPYSHGLAQPDVQHFPSEA (in isoform 2)"
FT /id="VSP_058875"
FT VAR_SEQ 246..383
FT /note="Missing (in isoform 2)"
FT /id="VSP_058876"
SQ SEQUENCE 383 AA; 44916 MW; EA45A0228330D695 CRC64;
MDPNPFIYCT CCDCCKLGQP KLIKTPYPLP KHPTGKFKPV LPPPISKEHN SLLSQPGKST
VSPRDKVQSG NTESSKAPSE VIQVSPGYTL IRNREQISVT LGDEMFNRKK HLESDVLSKV
KFSRTDIISD LQEQIAELMA IIEQMNRDQQ SALKLLSKDL DLRCSNMKQK FETESRELKE
THREELERLE NNYKEALKAE KALAEEKLDK MSKEYKYLKS MFHVFQDSIY EEMEDKWLRR
KAEWEKDEKM EREKILLQQK CRIIKKFELQ SEEKKKKMNE SISAVSDNFA REKEELLRQH
DEDILQIQEL RKSKEILEAE LRAQATVLET LNTNLFQCQK ELERQKTIAA NLEKLFQTKL
AEAEEKHKYN IKTPTEENNC LRC
